Strengthening a consolidated memory: The key role of the reconsolidation process
The reconsolidation hypothesis posits that the presentation of a specific cue, previously associated with a life event, makes the stored memory pass from a stable to a reactivated state. In this state, memory is again labile and susceptible to different agents, which may either damage or improve the...
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2014
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n4-6_p323_Forcato http://hdl.handle.net/20.500.12110/paper_09284257_v108_n4-6_p323_Forcato |
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paper:paper_09284257_v108_n4-6_p323_Forcato2023-06-08T15:52:16Z Strengthening a consolidated memory: The key role of the reconsolidation process Forcato, Cecilia Pedreira, Maria Eugenia Declarative memory Memory reconsolidation Mismatch Strengthening function Translational applications n methyl dextro aspartic acid receptor accuracy amnesia cognition cognitive rehabilitation declarative memory drug dependence episodic memory GABAergic system human learning memory memory consolidation memory disorder memory reconsolidation memory strengthening mental performance neuromodulation nonhuman reinforcement Review stress animal long term memory memory physiology recall time Animals Humans Memory Mental Recall Retention (Psychology) Time Factors The reconsolidation hypothesis posits that the presentation of a specific cue, previously associated with a life event, makes the stored memory pass from a stable to a reactivated state. In this state, memory is again labile and susceptible to different agents, which may either damage or improve the original memory. Such susceptibility decreases over time and leads to a re-stabilization phase known as reconsolidation process. This process has been assigned two biological roles: memory updating, which suggests that destabilization of the original memory allows the integration of new information into the background of the original memory; and memory strengthening, which postulates that the labilization-reconsolidation process strengthens the original memory. The aim of this review is to analyze the strengthening as an improvement obtained only by triggering such process without any other treatment. In our lab, we have demonstrated that when triggering the labilization-reconsolidation process at least once the original memory becomes strengthened and increases its persistence. We have also shown that repeated labilization-reconsolidation processes strengthened the original memory by enlarging its precision, and said reinforced memories were more resistant to interference. Finally, we have shown that the strengthening function is not operative in older memories. We present and discuss both our findings and those of others, trying to reveal the central role of reconsolidation in the modification of stored information. © 2014 Elsevier Ltd. Fil:Forcato, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pedreira, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n4-6_p323_Forcato http://hdl.handle.net/20.500.12110/paper_09284257_v108_n4-6_p323_Forcato |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Declarative memory Memory reconsolidation Mismatch Strengthening function Translational applications n methyl dextro aspartic acid receptor accuracy amnesia cognition cognitive rehabilitation declarative memory drug dependence episodic memory GABAergic system human learning memory memory consolidation memory disorder memory reconsolidation memory strengthening mental performance neuromodulation nonhuman reinforcement Review stress animal long term memory memory physiology recall time Animals Humans Memory Mental Recall Retention (Psychology) Time Factors |
| spellingShingle |
Declarative memory Memory reconsolidation Mismatch Strengthening function Translational applications n methyl dextro aspartic acid receptor accuracy amnesia cognition cognitive rehabilitation declarative memory drug dependence episodic memory GABAergic system human learning memory memory consolidation memory disorder memory reconsolidation memory strengthening mental performance neuromodulation nonhuman reinforcement Review stress animal long term memory memory physiology recall time Animals Humans Memory Mental Recall Retention (Psychology) Time Factors Forcato, Cecilia Pedreira, Maria Eugenia Strengthening a consolidated memory: The key role of the reconsolidation process |
| topic_facet |
Declarative memory Memory reconsolidation Mismatch Strengthening function Translational applications n methyl dextro aspartic acid receptor accuracy amnesia cognition cognitive rehabilitation declarative memory drug dependence episodic memory GABAergic system human learning memory memory consolidation memory disorder memory reconsolidation memory strengthening mental performance neuromodulation nonhuman reinforcement Review stress animal long term memory memory physiology recall time Animals Humans Memory Mental Recall Retention (Psychology) Time Factors |
| description |
The reconsolidation hypothesis posits that the presentation of a specific cue, previously associated with a life event, makes the stored memory pass from a stable to a reactivated state. In this state, memory is again labile and susceptible to different agents, which may either damage or improve the original memory. Such susceptibility decreases over time and leads to a re-stabilization phase known as reconsolidation process. This process has been assigned two biological roles: memory updating, which suggests that destabilization of the original memory allows the integration of new information into the background of the original memory; and memory strengthening, which postulates that the labilization-reconsolidation process strengthens the original memory. The aim of this review is to analyze the strengthening as an improvement obtained only by triggering such process without any other treatment. In our lab, we have demonstrated that when triggering the labilization-reconsolidation process at least once the original memory becomes strengthened and increases its persistence. We have also shown that repeated labilization-reconsolidation processes strengthened the original memory by enlarging its precision, and said reinforced memories were more resistant to interference. Finally, we have shown that the strengthening function is not operative in older memories. We present and discuss both our findings and those of others, trying to reveal the central role of reconsolidation in the modification of stored information. © 2014 Elsevier Ltd. |
| author |
Forcato, Cecilia Pedreira, Maria Eugenia |
| author_facet |
Forcato, Cecilia Pedreira, Maria Eugenia |
| author_sort |
Forcato, Cecilia |
| title |
Strengthening a consolidated memory: The key role of the reconsolidation process |
| title_short |
Strengthening a consolidated memory: The key role of the reconsolidation process |
| title_full |
Strengthening a consolidated memory: The key role of the reconsolidation process |
| title_fullStr |
Strengthening a consolidated memory: The key role of the reconsolidation process |
| title_full_unstemmed |
Strengthening a consolidated memory: The key role of the reconsolidation process |
| title_sort |
strengthening a consolidated memory: the key role of the reconsolidation process |
| publishDate |
2014 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n4-6_p323_Forcato http://hdl.handle.net/20.500.12110/paper_09284257_v108_n4-6_p323_Forcato |
| work_keys_str_mv |
AT forcatocecilia strengtheningaconsolidatedmemorythekeyroleofthereconsolidationprocess AT pedreiramariaeugenia strengtheningaconsolidatedmemorythekeyroleofthereconsolidationprocess |
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1768544826629816320 |