Memory beyond expression
The idea that memories are not invariable after the consolidation process has led to new perspectives about several mnemonic processes. In this framework, we review our studies on the modulation of memory expression during reconsolidation. We propose that during both memory consolidation and reconso...
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2014
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n4-6_p307_Delorenzi http://hdl.handle.net/20.500.12110/paper_09284257_v108_n4-6_p307_Delorenzi |
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paper:paper_09284257_v108_n4-6_p307_Delorenzi2023-06-08T15:52:15Z Memory beyond expression Delorenzi, Alejandro Maza, Francisco Javier Suarez, Luis Daniel Barreiro, Karina Andrea Consolidation Expression Forgetting Memory Reconsolidation Retrieval angiotensin behavior Chasmagnathus crab declarative memory experimental amnesia fear human information retrieval learning long term memory memory memory consolidation memory expression memory reconsolidation neuromodulation nonhuman Review short term memory signal processing training animal animal model memory memory disorder physiology teaching time Animals Humans Memory Memory Disorders Models, Animal Teaching Time Factors The idea that memories are not invariable after the consolidation process has led to new perspectives about several mnemonic processes. In this framework, we review our studies on the modulation of memory expression during reconsolidation. We propose that during both memory consolidation and reconsolidation, neuromodulators can determine the probability of the memory trace to guide behavior, i.e. they can either increase or decrease its behavioral expressibility without affecting the potential of persistent memories to be activated and become labile. Our hypothesis is based on the findings that positive modulation of memory expression during reconsolidation occurs even if memories are behaviorally unexpressed. This review discusses the original approach taken in the studies of the crab Neohelice (Chasmagnathus) granulata, which was then successfully applied to test the hypothesis in rodent fear memory. Data presented offers a new way of thinking about both weak trainings and experimental amnesia: memory retrieval can be dissociated from memory expression. Furthermore, the strategy presented here allowed us to show in human declarative memory that the periods in which long-term memory can be activated and become labile during reconsolidation exceeds the periods in which that memory is expressed, providing direct evidence that conscious access to memory is not needed for reconsolidation. Specific controls based on the constraints of reminders to trigger reconsolidation allow us to distinguish between obliterated and unexpressed but activated long-term memories after amnesic treatments, weak trainings and forgetting. In the hypothesis discussed, memory expressibility - the outcome of experience-dependent changes in the potential to behave - is considered as a flexible and modulable attribute of long-term memories. Expression seems to be just one of the possible fates of re-activated memories. © 2014 Elsevier Ltd. Fil:Delorenzi, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Maza, F.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Suárez, L.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Barreiro, K. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n4-6_p307_Delorenzi http://hdl.handle.net/20.500.12110/paper_09284257_v108_n4-6_p307_Delorenzi |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Consolidation Expression Forgetting Memory Reconsolidation Retrieval angiotensin behavior Chasmagnathus crab declarative memory experimental amnesia fear human information retrieval learning long term memory memory memory consolidation memory expression memory reconsolidation neuromodulation nonhuman Review short term memory signal processing training animal animal model memory memory disorder physiology teaching time Animals Humans Memory Memory Disorders Models, Animal Teaching Time Factors |
| spellingShingle |
Consolidation Expression Forgetting Memory Reconsolidation Retrieval angiotensin behavior Chasmagnathus crab declarative memory experimental amnesia fear human information retrieval learning long term memory memory memory consolidation memory expression memory reconsolidation neuromodulation nonhuman Review short term memory signal processing training animal animal model memory memory disorder physiology teaching time Animals Humans Memory Memory Disorders Models, Animal Teaching Time Factors Delorenzi, Alejandro Maza, Francisco Javier Suarez, Luis Daniel Barreiro, Karina Andrea Memory beyond expression |
| topic_facet |
Consolidation Expression Forgetting Memory Reconsolidation Retrieval angiotensin behavior Chasmagnathus crab declarative memory experimental amnesia fear human information retrieval learning long term memory memory memory consolidation memory expression memory reconsolidation neuromodulation nonhuman Review short term memory signal processing training animal animal model memory memory disorder physiology teaching time Animals Humans Memory Memory Disorders Models, Animal Teaching Time Factors |
| description |
The idea that memories are not invariable after the consolidation process has led to new perspectives about several mnemonic processes. In this framework, we review our studies on the modulation of memory expression during reconsolidation. We propose that during both memory consolidation and reconsolidation, neuromodulators can determine the probability of the memory trace to guide behavior, i.e. they can either increase or decrease its behavioral expressibility without affecting the potential of persistent memories to be activated and become labile. Our hypothesis is based on the findings that positive modulation of memory expression during reconsolidation occurs even if memories are behaviorally unexpressed. This review discusses the original approach taken in the studies of the crab Neohelice (Chasmagnathus) granulata, which was then successfully applied to test the hypothesis in rodent fear memory. Data presented offers a new way of thinking about both weak trainings and experimental amnesia: memory retrieval can be dissociated from memory expression. Furthermore, the strategy presented here allowed us to show in human declarative memory that the periods in which long-term memory can be activated and become labile during reconsolidation exceeds the periods in which that memory is expressed, providing direct evidence that conscious access to memory is not needed for reconsolidation. Specific controls based on the constraints of reminders to trigger reconsolidation allow us to distinguish between obliterated and unexpressed but activated long-term memories after amnesic treatments, weak trainings and forgetting. In the hypothesis discussed, memory expressibility - the outcome of experience-dependent changes in the potential to behave - is considered as a flexible and modulable attribute of long-term memories. Expression seems to be just one of the possible fates of re-activated memories. © 2014 Elsevier Ltd. |
| author |
Delorenzi, Alejandro Maza, Francisco Javier Suarez, Luis Daniel Barreiro, Karina Andrea |
| author_facet |
Delorenzi, Alejandro Maza, Francisco Javier Suarez, Luis Daniel Barreiro, Karina Andrea |
| author_sort |
Delorenzi, Alejandro |
| title |
Memory beyond expression |
| title_short |
Memory beyond expression |
| title_full |
Memory beyond expression |
| title_fullStr |
Memory beyond expression |
| title_full_unstemmed |
Memory beyond expression |
| title_sort |
memory beyond expression |
| publishDate |
2014 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v108_n4-6_p307_Delorenzi http://hdl.handle.net/20.500.12110/paper_09284257_v108_n4-6_p307_Delorenzi |
| work_keys_str_mv |
AT delorenzialejandro memorybeyondexpression AT mazafranciscojavier memorybeyondexpression AT suarezluisdaniel memorybeyondexpression AT barreirokarinaandrea memorybeyondexpression |
| _version_ |
1768543332230758400 |