Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus

The in vitro antiviral activity of antimicrobial cationic peptides: cecropin A, melittin, magainin I and II and indolicidin against the arenavirus Junin virus (JV), and herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) was evaluated. Cecropin A effectively inhibited JV multiplication and failed to a...

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Autores principales:	Albiol Matanic, Vanesa Cintia, Castilla, Viviana
Publicado:	2004
Materias:	Antimicrobial peptides Antiviral activity Arenavirus Herpesvirus antivirus agent cecropin A indolicidin magainin 1 magainin 2 melittin protein animal cell antiviral activity article controlled study Herpes simplex virus 1 Herpes simplex virus 2 host cell in vitro study Junin virus nonhuman Pichinde arenavirus priority journal virus inactivation virus morphogenesis virus replication Animals Anti-Infective Agents Antimicrobial Cationic Peptides Cell Line Cercopithecus aethiops Cricetinae Herpesvirus 1, Human Herpesvirus 2, Human Microbial Sensitivity Tests Vero Cells Virus Replication
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09248579_v23_n4_p382_AlbiolMatanic http://hdl.handle.net/20.500.12110/paper_09248579_v23_n4_p382_AlbiolMatanic
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09248579_v23_n4_p382_AlbiolMatanic
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spelling	paper:paper_09248579_v23_n4_p382_AlbiolMatanic2023-06-08T15:51:10Z Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus Albiol Matanic, Vanesa Cintia Castilla, Viviana Antimicrobial peptides Antiviral activity Arenavirus Herpesvirus antivirus agent cecropin A indolicidin magainin 1 magainin 2 melittin protein animal cell antiviral activity Arenavirus article controlled study Herpes simplex virus 1 Herpes simplex virus 2 host cell in vitro study Junin virus nonhuman Pichinde arenavirus priority journal virus inactivation virus morphogenesis virus replication Animals Anti-Infective Agents Antimicrobial Cationic Peptides Cell Line Cercopithecus aethiops Cricetinae Herpesvirus 1, Human Herpesvirus 2, Human Junin virus Microbial Sensitivity Tests Vero Cells Virus Replication The in vitro antiviral activity of antimicrobial cationic peptides: cecropin A, melittin, magainin I and II and indolicidin against the arenavirus Junin virus (JV), and herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) was evaluated. Cecropin A effectively inhibited JV multiplication and failed to affect HSV replication whereas melittin impeded the multiplication of JV and HSV, but was highly toxic for the host cell. Magainins I and II exhibited inhibitory action toward HSV-1 and HSV-2 but were inactive against JV. Only indolicidin showed a direct inactivation effect on cell-free virus stocks. Besides its inhibitory effect on JV replication cecropin A also was active against the arenaviruses Tacaribe and Pichinde, mainly affecting late events of arenavirus multiplication cycle by preventing viral morphogenesis and egress from infected cells. © 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved. Fil:Albiol Matanic, V.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Castilla, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2004 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09248579_v23_n4_p382_AlbiolMatanic http://hdl.handle.net/20.500.12110/paper_09248579_v23_n4_p382_AlbiolMatanic
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Antimicrobial peptides Antiviral activity Arenavirus Herpesvirus antivirus agent cecropin A indolicidin magainin 1 magainin 2 melittin protein animal cell antiviral activity Arenavirus article controlled study Herpes simplex virus 1 Herpes simplex virus 2 host cell in vitro study Junin virus nonhuman Pichinde arenavirus priority journal virus inactivation virus morphogenesis virus replication Animals Anti-Infective Agents Antimicrobial Cationic Peptides Cell Line Cercopithecus aethiops Cricetinae Herpesvirus 1, Human Herpesvirus 2, Human Junin virus Microbial Sensitivity Tests Vero Cells Virus Replication
spellingShingle	Antimicrobial peptides Antiviral activity Arenavirus Herpesvirus antivirus agent cecropin A indolicidin magainin 1 magainin 2 melittin protein animal cell antiviral activity Arenavirus article controlled study Herpes simplex virus 1 Herpes simplex virus 2 host cell in vitro study Junin virus nonhuman Pichinde arenavirus priority journal virus inactivation virus morphogenesis virus replication Animals Anti-Infective Agents Antimicrobial Cationic Peptides Cell Line Cercopithecus aethiops Cricetinae Herpesvirus 1, Human Herpesvirus 2, Human Junin virus Microbial Sensitivity Tests Vero Cells Virus Replication Albiol Matanic, Vanesa Cintia Castilla, Viviana Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus
topic_facet	Antimicrobial peptides Antiviral activity Arenavirus Herpesvirus antivirus agent cecropin A indolicidin magainin 1 magainin 2 melittin protein animal cell antiviral activity Arenavirus article controlled study Herpes simplex virus 1 Herpes simplex virus 2 host cell in vitro study Junin virus nonhuman Pichinde arenavirus priority journal virus inactivation virus morphogenesis virus replication Animals Anti-Infective Agents Antimicrobial Cationic Peptides Cell Line Cercopithecus aethiops Cricetinae Herpesvirus 1, Human Herpesvirus 2, Human Junin virus Microbial Sensitivity Tests Vero Cells Virus Replication
description	The in vitro antiviral activity of antimicrobial cationic peptides: cecropin A, melittin, magainin I and II and indolicidin against the arenavirus Junin virus (JV), and herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) was evaluated. Cecropin A effectively inhibited JV multiplication and failed to affect HSV replication whereas melittin impeded the multiplication of JV and HSV, but was highly toxic for the host cell. Magainins I and II exhibited inhibitory action toward HSV-1 and HSV-2 but were inactive against JV. Only indolicidin showed a direct inactivation effect on cell-free virus stocks. Besides its inhibitory effect on JV replication cecropin A also was active against the arenaviruses Tacaribe and Pichinde, mainly affecting late events of arenavirus multiplication cycle by preventing viral morphogenesis and egress from infected cells. © 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
author	Albiol Matanic, Vanesa Cintia Castilla, Viviana
author_facet	Albiol Matanic, Vanesa Cintia Castilla, Viviana
author_sort	Albiol Matanic, Vanesa Cintia
title	Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus
title_short	Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus
title_full	Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus
title_fullStr	Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus
title_full_unstemmed	Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus
title_sort	antiviral activity of antimicrobial cationic peptides against junin virus and herpes simplex virus
publishDate	2004
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09248579_v23_n4_p382_AlbiolMatanic http://hdl.handle.net/20.500.12110/paper_09248579_v23_n4_p382_AlbiolMatanic
work_keys_str_mv	AT albiolmatanicvanesacintia antiviralactivityofantimicrobialcationicpeptidesagainstjuninvirusandherpessimplexvirus AT castillaviviana antiviralactivityofantimicrobialcationicpeptidesagainstjuninvirusandherpessimplexvirus
_version_	1768545838993244160

Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus

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