Progesterone reduces secondary damage, preserves white matter, and improves locomotor outcome after spinal cord contusion
Progesterone is an anti-inflammatory and promyelinating agent after spinal cord injury, but its effectiveness on functional recovery is still controversial. In the current study, we tested the effects of chronic progesterone administration on tissue preservation and functional recovery in a clinical...
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2014
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08977151_v31_n9_p857_GarciaOvejero http://hdl.handle.net/20.500.12110/paper_08977151_v31_n9_p857_GarciaOvejero |
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paper:paper_08977151_v31_n9_p857_GarciaOvejero2023-06-08T15:49:21Z Progesterone reduces secondary damage, preserves white matter, and improves locomotor outcome after spinal cord contusion CatWalk oligodendrocytes progesterone spare white matter spinal cord injury myelin basic protein progesterone gestagen progesterone adult animal experiment animal model article catwalk gait analysis test cell counting controlled study drug mechanism immunoreactivity locomotion male nerve regeneration nonhuman nuclear magnetic resonance imaging oligodendroglia open field behavior rat spinal cord injury tissue preservation treatment outcome white matter young adult animal convalescence disease model drug effects immunohistochemistry motor activity pathology spinal cord injury white matter Wistar rat Animals Disease Models, Animal Immunohistochemistry Magnetic Resonance Imaging Male Motor Activity Progesterone Progestins Rats Rats, Wistar Recovery of Function Spinal Cord Injuries White Matter Progesterone is an anti-inflammatory and promyelinating agent after spinal cord injury, but its effectiveness on functional recovery is still controversial. In the current study, we tested the effects of chronic progesterone administration on tissue preservation and functional recovery in a clinically relevant model of spinal cord lesion (thoracic contusion). Using magnetic resonance imaging, we observed that progesterone reduced both volume and rostrocaudal extension of the lesion at 60 days post-injury. In addition, progesterone increased the number of total mature oligodendrocytes, myelin basic protein immunoreactivity, and the number of axonal profiles at the epicenter of the lesion. Further, progesterone treatment significantly improved motor outcome as assessed using the Basso-Bresnahan-Beattie scale for locomotion and CatWalk gait analysis. These data suggest that progesterone could be considered a promising therapeutical candidate for spinal cord injury. © 2014 Mary Ann Liebert, Inc. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08977151_v31_n9_p857_GarciaOvejero http://hdl.handle.net/20.500.12110/paper_08977151_v31_n9_p857_GarciaOvejero |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
CatWalk oligodendrocytes progesterone spare white matter spinal cord injury myelin basic protein progesterone gestagen progesterone adult animal experiment animal model article catwalk gait analysis test cell counting controlled study drug mechanism immunoreactivity locomotion male nerve regeneration nonhuman nuclear magnetic resonance imaging oligodendroglia open field behavior rat spinal cord injury tissue preservation treatment outcome white matter young adult animal convalescence disease model drug effects immunohistochemistry motor activity pathology spinal cord injury white matter Wistar rat Animals Disease Models, Animal Immunohistochemistry Magnetic Resonance Imaging Male Motor Activity Progesterone Progestins Rats Rats, Wistar Recovery of Function Spinal Cord Injuries White Matter |
| spellingShingle |
CatWalk oligodendrocytes progesterone spare white matter spinal cord injury myelin basic protein progesterone gestagen progesterone adult animal experiment animal model article catwalk gait analysis test cell counting controlled study drug mechanism immunoreactivity locomotion male nerve regeneration nonhuman nuclear magnetic resonance imaging oligodendroglia open field behavior rat spinal cord injury tissue preservation treatment outcome white matter young adult animal convalescence disease model drug effects immunohistochemistry motor activity pathology spinal cord injury white matter Wistar rat Animals Disease Models, Animal Immunohistochemistry Magnetic Resonance Imaging Male Motor Activity Progesterone Progestins Rats Rats, Wistar Recovery of Function Spinal Cord Injuries White Matter Progesterone reduces secondary damage, preserves white matter, and improves locomotor outcome after spinal cord contusion |
| topic_facet |
CatWalk oligodendrocytes progesterone spare white matter spinal cord injury myelin basic protein progesterone gestagen progesterone adult animal experiment animal model article catwalk gait analysis test cell counting controlled study drug mechanism immunoreactivity locomotion male nerve regeneration nonhuman nuclear magnetic resonance imaging oligodendroglia open field behavior rat spinal cord injury tissue preservation treatment outcome white matter young adult animal convalescence disease model drug effects immunohistochemistry motor activity pathology spinal cord injury white matter Wistar rat Animals Disease Models, Animal Immunohistochemistry Magnetic Resonance Imaging Male Motor Activity Progesterone Progestins Rats Rats, Wistar Recovery of Function Spinal Cord Injuries White Matter |
| description |
Progesterone is an anti-inflammatory and promyelinating agent after spinal cord injury, but its effectiveness on functional recovery is still controversial. In the current study, we tested the effects of chronic progesterone administration on tissue preservation and functional recovery in a clinically relevant model of spinal cord lesion (thoracic contusion). Using magnetic resonance imaging, we observed that progesterone reduced both volume and rostrocaudal extension of the lesion at 60 days post-injury. In addition, progesterone increased the number of total mature oligodendrocytes, myelin basic protein immunoreactivity, and the number of axonal profiles at the epicenter of the lesion. Further, progesterone treatment significantly improved motor outcome as assessed using the Basso-Bresnahan-Beattie scale for locomotion and CatWalk gait analysis. These data suggest that progesterone could be considered a promising therapeutical candidate for spinal cord injury. © 2014 Mary Ann Liebert, Inc. |
| title |
Progesterone reduces secondary damage, preserves white matter, and improves locomotor outcome after spinal cord contusion |
| title_short |
Progesterone reduces secondary damage, preserves white matter, and improves locomotor outcome after spinal cord contusion |
| title_full |
Progesterone reduces secondary damage, preserves white matter, and improves locomotor outcome after spinal cord contusion |
| title_fullStr |
Progesterone reduces secondary damage, preserves white matter, and improves locomotor outcome after spinal cord contusion |
| title_full_unstemmed |
Progesterone reduces secondary damage, preserves white matter, and improves locomotor outcome after spinal cord contusion |
| title_sort |
progesterone reduces secondary damage, preserves white matter, and improves locomotor outcome after spinal cord contusion |
| publishDate |
2014 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08977151_v31_n9_p857_GarciaOvejero http://hdl.handle.net/20.500.12110/paper_08977151_v31_n9_p857_GarciaOvejero |
| _version_ |
1768542321798807552 |