Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction
It is demonstrated that human IgG in Chagas' disease and the corresponding F(ab)'2 fragment attach to lymphoid cells by specific interaction with β-adrenergic and muscarinic cholinergic receptors. This interaction resulted in the transduction of signals that increased intracellular levels...
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1990
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08926638_v4_n6_p1661_SterinBorda http://hdl.handle.net/20.500.12110/paper_08926638_v4_n6_p1661_SterinBorda |
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paper:paper_08926638_v4_n6_p1661_SterinBorda |
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dspace |
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paper:paper_08926638_v4_n6_p1661_SterinBorda2023-06-08T15:47:24Z Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction antineurotransmitter IgG cAMP cGMP Chagas' disease PGE T helper cell β adrenoreceptor T suppressor cholinergic receptor cholinergic receptor cyclic amp cyclic gmp immunoglobulin g muscarinic receptor neurotransmitter receptor prostaglandin e2 radioisotope article chagas disease helper cell human human cell immunoregulation priority journal signal transduction suppressor cell t lymphocyte Binding, Competitive Chagas Disease Cyclic AMP Cyclic GMP Dinoprostone Human Immunoglobulin G Receptors, Adrenergic, beta Receptors, Muscarinic Signal Transduction Support, Non-U.S. Gov't T-Lymphocytes T-Lymphocytes, Helper-Inducer T-Lymphocytes, Suppressor-Effector It is demonstrated that human IgG in Chagas' disease and the corresponding F(ab)'2 fragment attach to lymphoid cells by specific interaction with β-adrenergic and muscarinic cholinergic receptors. This interaction resulted in the transduction of signals that increased intracellular levels of cAMP in enriched T helper cell preparations and cGMP in enriched T suppressor cell preparations. The stimulation of Ts cell muscarinic cholinergic receptors by Chagas IgG or the corresponding F(ab)'2 fraction triggers the release of the immunomodulatory substance PGE2. These results are unified in a theory of immunoregulation and could contribute to the chronic course of Chagas' disease. 1990 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08926638_v4_n6_p1661_SterinBorda http://hdl.handle.net/20.500.12110/paper_08926638_v4_n6_p1661_SterinBorda |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
antineurotransmitter IgG cAMP cGMP Chagas' disease PGE T helper cell β adrenoreceptor T suppressor cholinergic receptor cholinergic receptor cyclic amp cyclic gmp immunoglobulin g muscarinic receptor neurotransmitter receptor prostaglandin e2 radioisotope article chagas disease helper cell human human cell immunoregulation priority journal signal transduction suppressor cell t lymphocyte Binding, Competitive Chagas Disease Cyclic AMP Cyclic GMP Dinoprostone Human Immunoglobulin G Receptors, Adrenergic, beta Receptors, Muscarinic Signal Transduction Support, Non-U.S. Gov't T-Lymphocytes T-Lymphocytes, Helper-Inducer T-Lymphocytes, Suppressor-Effector |
| spellingShingle |
antineurotransmitter IgG cAMP cGMP Chagas' disease PGE T helper cell β adrenoreceptor T suppressor cholinergic receptor cholinergic receptor cyclic amp cyclic gmp immunoglobulin g muscarinic receptor neurotransmitter receptor prostaglandin e2 radioisotope article chagas disease helper cell human human cell immunoregulation priority journal signal transduction suppressor cell t lymphocyte Binding, Competitive Chagas Disease Cyclic AMP Cyclic GMP Dinoprostone Human Immunoglobulin G Receptors, Adrenergic, beta Receptors, Muscarinic Signal Transduction Support, Non-U.S. Gov't T-Lymphocytes T-Lymphocytes, Helper-Inducer T-Lymphocytes, Suppressor-Effector Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction |
| topic_facet |
antineurotransmitter IgG cAMP cGMP Chagas' disease PGE T helper cell β adrenoreceptor T suppressor cholinergic receptor cholinergic receptor cyclic amp cyclic gmp immunoglobulin g muscarinic receptor neurotransmitter receptor prostaglandin e2 radioisotope article chagas disease helper cell human human cell immunoregulation priority journal signal transduction suppressor cell t lymphocyte Binding, Competitive Chagas Disease Cyclic AMP Cyclic GMP Dinoprostone Human Immunoglobulin G Receptors, Adrenergic, beta Receptors, Muscarinic Signal Transduction Support, Non-U.S. Gov't T-Lymphocytes T-Lymphocytes, Helper-Inducer T-Lymphocytes, Suppressor-Effector |
| description |
It is demonstrated that human IgG in Chagas' disease and the corresponding F(ab)'2 fragment attach to lymphoid cells by specific interaction with β-adrenergic and muscarinic cholinergic receptors. This interaction resulted in the transduction of signals that increased intracellular levels of cAMP in enriched T helper cell preparations and cGMP in enriched T suppressor cell preparations. The stimulation of Ts cell muscarinic cholinergic receptors by Chagas IgG or the corresponding F(ab)'2 fraction triggers the release of the immunomodulatory substance PGE2. These results are unified in a theory of immunoregulation and could contribute to the chronic course of Chagas' disease. |
| title |
Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction |
| title_short |
Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction |
| title_full |
Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction |
| title_fullStr |
Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction |
| title_full_unstemmed |
Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction |
| title_sort |
human chagasic igg interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction |
| publishDate |
1990 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08926638_v4_n6_p1661_SterinBorda http://hdl.handle.net/20.500.12110/paper_08926638_v4_n6_p1661_SterinBorda |
| _version_ |
1768542273826455552 |