Developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations

Experience-dependent plasticity during critical periods of postnatal (PN) development shapes the adult brain anatomy and function. In rat motor system, there is a critical period of activity-dependent plasticity in the striatum (PN30-37). In this period, motor activity of running in a circular path...

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Autores principales: Soiza Reilly, Mariano, Azcurra, Julio Marcos
Publicado: 2009
Materias:
Critical period
Haloperidol
Motor behavior
Plasticity
Postnatal development
Striatum
dopamine 2 receptor
haloperidol
animal experiment
article
behavior disorder
binding site
brain development
controlled study
corpus striatum
disease predisposition
instrumental conditioning
locomotion
male
motor performance
nerve cell plasticity
nonhuman
open field test
postnatal development
priority journal
protein expression
rat
Age Factors
Animals
Antipsychotic Agents
Binding Sites
Brain Chemistry
Corpus Striatum
Dopamine
Dopamine Antagonists
Dyskinesia, Drug-Induced
Male
Motor Activity
Neuronal Plasticity
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D2
RNA, Messenger
Time
Animalia
Rattus
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08920362_v31_n4_p191_SoizaReilly
http://hdl.handle.net/20.500.12110/paper_08920362_v31_n4_p191_SoizaReilly
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_08920362_v31_n4_p191_SoizaReilly
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spelling paper:paper_08920362_v31_n4_p191_SoizaReilly2023-06-08T15:47:17Z Developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations Soiza Reilly, Mariano Azcurra, Julio Marcos Critical period Haloperidol Motor behavior Plasticity Postnatal development Striatum dopamine 2 receptor haloperidol animal experiment article behavior disorder binding site brain development controlled study corpus striatum disease predisposition instrumental conditioning locomotion male motor performance nerve cell plasticity nonhuman open field test postnatal development priority journal protein expression rat Age Factors Animals Antipsychotic Agents Binding Sites Brain Chemistry Corpus Striatum Dopamine Dopamine Antagonists Dyskinesia, Drug-Induced Haloperidol Male Motor Activity Neuronal Plasticity Rats Rats, Sprague-Dawley Receptors, Dopamine D2 RNA, Messenger Time Animalia Rattus Experience-dependent plasticity during critical periods of postnatal (PN) development shapes the adult brain anatomy and function. In rat motor system, there is a critical period of activity-dependent plasticity in the striatum (PN30-37). In this period, motor activity of running in a circular path induced in the Circling Training test (CT), elicits several plasticity changes on striatal synapses. It has been recently proposed that developmental critical periods might represent a unique pharmacological window of vulnerability to induce life-lasting behavioral modifications. In this paper we tested the hypothesis of existence of a pharmacological susceptibility to induce adult alterations on motor behavior during the striatal critical period. Due to its main action on the striatum and developmental motor behavioral effects, we applied the prototypical antipsychotic haloperidol to male rats (i.p. 0.7 or 2.5 mg/kg/day) before, during or after the period of plasticity (PN20-27, PN30-37 or PN40-47 respectively). Then, in the adulthood (PN80), we evaluated induced motor activity in the CT. The results showed that only rats exposed to the D2R blocker during the period PN30-37 increased the CT activity in comparison to control rats. Moreover, only these animals also showed an increase in the spontaneous locomotor activity at the open field test. These behavioral alterations were not accompanied by permanent striatal changes either on the number of D2R binding sites or on its mRNA expression levels. In conclusion, we have shown a pharmacological susceptibility of inducing adult motor behavior alterations by haloperidol during a natural critical period of activity-dependent plasticity (PN30-37) in rat striatum development. These results also emphasize the importance of behavioral screening for pharmacological agents to be used in developmental stages of maturation. © 2009 Elsevier Inc. All rights reserved. Fil:Soiza-Reilly, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Azcurra, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08920362_v31_n4_p191_SoizaReilly http://hdl.handle.net/20.500.12110/paper_08920362_v31_n4_p191_SoizaReilly
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Critical period
Haloperidol
Motor behavior
Plasticity
Postnatal development
Striatum
dopamine 2 receptor
haloperidol
animal experiment
article
behavior disorder
binding site
brain development
controlled study
corpus striatum
disease predisposition
instrumental conditioning
locomotion
male
motor performance
nerve cell plasticity
nonhuman
open field test
postnatal development
priority journal
protein expression
rat
Age Factors
Animals
Antipsychotic Agents
Binding Sites
Brain Chemistry
Corpus Striatum
Dopamine
Dopamine Antagonists
Dyskinesia, Drug-Induced
Haloperidol
Male
Motor Activity
Neuronal Plasticity
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D2
RNA, Messenger
Time
Animalia
Rattus
spellingShingle Critical period
Haloperidol
Motor behavior
Plasticity
Postnatal development
Striatum
dopamine 2 receptor
haloperidol
animal experiment
article
behavior disorder
binding site
brain development
controlled study
corpus striatum
disease predisposition
instrumental conditioning
locomotion
male
motor performance
nerve cell plasticity
nonhuman
open field test
postnatal development
priority journal
protein expression
rat
Age Factors
Animals
Antipsychotic Agents
Binding Sites
Brain Chemistry
Corpus Striatum
Dopamine
Dopamine Antagonists
Dyskinesia, Drug-Induced
Haloperidol
Male
Motor Activity
Neuronal Plasticity
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D2
RNA, Messenger
Time
Animalia
Rattus
Soiza Reilly, Mariano
Azcurra, Julio Marcos
Developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations
topic_facet Critical period
Haloperidol
Motor behavior
Plasticity
Postnatal development
Striatum
dopamine 2 receptor
haloperidol
animal experiment
article
behavior disorder
binding site
brain development
controlled study
corpus striatum
disease predisposition
instrumental conditioning
locomotion
male
motor performance
nerve cell plasticity
nonhuman
open field test
postnatal development
priority journal
protein expression
rat
Age Factors
Animals
Antipsychotic Agents
Binding Sites
Brain Chemistry
Corpus Striatum
Dopamine
Dopamine Antagonists
Dyskinesia, Drug-Induced
Haloperidol
Male
Motor Activity
Neuronal Plasticity
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D2
RNA, Messenger
Time
Animalia
Rattus
description Experience-dependent plasticity during critical periods of postnatal (PN) development shapes the adult brain anatomy and function. In rat motor system, there is a critical period of activity-dependent plasticity in the striatum (PN30-37). In this period, motor activity of running in a circular path induced in the Circling Training test (CT), elicits several plasticity changes on striatal synapses. It has been recently proposed that developmental critical periods might represent a unique pharmacological window of vulnerability to induce life-lasting behavioral modifications. In this paper we tested the hypothesis of existence of a pharmacological susceptibility to induce adult alterations on motor behavior during the striatal critical period. Due to its main action on the striatum and developmental motor behavioral effects, we applied the prototypical antipsychotic haloperidol to male rats (i.p. 0.7 or 2.5 mg/kg/day) before, during or after the period of plasticity (PN20-27, PN30-37 or PN40-47 respectively). Then, in the adulthood (PN80), we evaluated induced motor activity in the CT. The results showed that only rats exposed to the D2R blocker during the period PN30-37 increased the CT activity in comparison to control rats. Moreover, only these animals also showed an increase in the spontaneous locomotor activity at the open field test. These behavioral alterations were not accompanied by permanent striatal changes either on the number of D2R binding sites or on its mRNA expression levels. In conclusion, we have shown a pharmacological susceptibility of inducing adult motor behavior alterations by haloperidol during a natural critical period of activity-dependent plasticity (PN30-37) in rat striatum development. These results also emphasize the importance of behavioral screening for pharmacological agents to be used in developmental stages of maturation. © 2009 Elsevier Inc. All rights reserved.
author Soiza Reilly, Mariano
Azcurra, Julio Marcos
author_facet Soiza Reilly, Mariano
Azcurra, Julio Marcos
author_sort Soiza Reilly, Mariano
title Developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations
title_short Developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations
title_full Developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations
title_fullStr Developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations
title_full_unstemmed Developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations
title_sort developmental striatal critical period of activity-dependent plasticity is also a window of susceptibility for haloperidol induced adult motor alterations
publishDate 2009
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08920362_v31_n4_p191_SoizaReilly
http://hdl.handle.net/20.500.12110/paper_08920362_v31_n4_p191_SoizaReilly
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AT azcurrajuliomarcos developmentalstriatalcriticalperiodofactivitydependentplasticityisalsoawindowofsusceptibilityforhaloperidolinducedadultmotoralterations
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