Attenuated methamphetamine induced neurotoxicity by modafinil administration in mice
Methamphetamine (METH) is a highly addictive drug that might induce neurotoxicity. Clinical trials have reported that modafinil, a wake-promoting agent used to treat sleep disorders, may have some efficacy for the treatment of psychostimulant addiction. In this study we tested possible neuroprotecti...
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2011
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08874476_v65_n10_p1087_Raineri http://hdl.handle.net/20.500.12110/paper_08874476_v65_n10_p1087_Raineri |
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paper:paper_08874476_v65_n10_p1087_Raineri2023-06-08T15:46:51Z Attenuated methamphetamine induced neurotoxicity by modafinil administration in mice Behavior Dopamine (DA) Modafinil Neurotoxicity dopamine methamphetamine modafinil tyrosine 3 monooxygenase animal experiment animal model article controlled study corpus striatum drug effect drug efficacy locomotion male mouse neuroprotection neurotoxicity nonhuman priority journal stereotypy treatment outcome Amphetamine-Related Disorders Animals Benzhydryl Compounds Central Nervous System Stimulants Drug Administration Schedule Drug Interactions Male Methamphetamine Mice Motor Activity Neuroprotective Agents Stereotyped Behavior Methamphetamine (METH) is a highly addictive drug that might induce neurotoxicity. Clinical trials have reported that modafinil, a wake-promoting agent used to treat sleep disorders, may have some efficacy for the treatment of psychostimulant addiction. In this study we tested possible neuroprotective effects of modafinil after toxic METH administration in mice. We evaluated the effect of modafinil (two injections of either 90 or 180 mg/kg) and METH binge (3 × 7 mg/kg i.p. injections, 3-h apart) coadministration on DA striatal content, TH immunoreactivity in striatal areas and spontaneous locomotor activity. We also investigated acute locomotor activity and stereotypy profile in mice treated with a single METH dose (2 and 7 mg/kg) pretreated with modafinil (90 and 180 mg/kg). We found that mice treated with a METH binge showed a marked decrease in DA and dopaminergic metabolites as well as lower levels of TH immunoreactivity in the dorsal striatum. Pretreatment with modafinil (both 90 and 180 mg/kg) attenuated these effects but did not prevent METH induced decrease in locomotion. We also found that groups that received the combination of both modafinil and single dose METH showed a decrease in total distance traveled in an open field compared with METH groups. We observed an increment in the time mice expended doing stereotypic movements (continuous sniffing) in the group that received the combination of both METH and modafinil (i.e., decreasing locomotion). Our results suggest a possible protective role of modafinil against METH acute striatal toxicity. Synapse 2011. © 2011 Wiley-Liss, Inc. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08874476_v65_n10_p1087_Raineri http://hdl.handle.net/20.500.12110/paper_08874476_v65_n10_p1087_Raineri |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Behavior Dopamine (DA) Modafinil Neurotoxicity dopamine methamphetamine modafinil tyrosine 3 monooxygenase animal experiment animal model article controlled study corpus striatum drug effect drug efficacy locomotion male mouse neuroprotection neurotoxicity nonhuman priority journal stereotypy treatment outcome Amphetamine-Related Disorders Animals Benzhydryl Compounds Central Nervous System Stimulants Drug Administration Schedule Drug Interactions Male Methamphetamine Mice Motor Activity Neuroprotective Agents Stereotyped Behavior |
| spellingShingle |
Behavior Dopamine (DA) Modafinil Neurotoxicity dopamine methamphetamine modafinil tyrosine 3 monooxygenase animal experiment animal model article controlled study corpus striatum drug effect drug efficacy locomotion male mouse neuroprotection neurotoxicity nonhuman priority journal stereotypy treatment outcome Amphetamine-Related Disorders Animals Benzhydryl Compounds Central Nervous System Stimulants Drug Administration Schedule Drug Interactions Male Methamphetamine Mice Motor Activity Neuroprotective Agents Stereotyped Behavior Attenuated methamphetamine induced neurotoxicity by modafinil administration in mice |
| topic_facet |
Behavior Dopamine (DA) Modafinil Neurotoxicity dopamine methamphetamine modafinil tyrosine 3 monooxygenase animal experiment animal model article controlled study corpus striatum drug effect drug efficacy locomotion male mouse neuroprotection neurotoxicity nonhuman priority journal stereotypy treatment outcome Amphetamine-Related Disorders Animals Benzhydryl Compounds Central Nervous System Stimulants Drug Administration Schedule Drug Interactions Male Methamphetamine Mice Motor Activity Neuroprotective Agents Stereotyped Behavior |
| description |
Methamphetamine (METH) is a highly addictive drug that might induce neurotoxicity. Clinical trials have reported that modafinil, a wake-promoting agent used to treat sleep disorders, may have some efficacy for the treatment of psychostimulant addiction. In this study we tested possible neuroprotective effects of modafinil after toxic METH administration in mice. We evaluated the effect of modafinil (two injections of either 90 or 180 mg/kg) and METH binge (3 × 7 mg/kg i.p. injections, 3-h apart) coadministration on DA striatal content, TH immunoreactivity in striatal areas and spontaneous locomotor activity. We also investigated acute locomotor activity and stereotypy profile in mice treated with a single METH dose (2 and 7 mg/kg) pretreated with modafinil (90 and 180 mg/kg). We found that mice treated with a METH binge showed a marked decrease in DA and dopaminergic metabolites as well as lower levels of TH immunoreactivity in the dorsal striatum. Pretreatment with modafinil (both 90 and 180 mg/kg) attenuated these effects but did not prevent METH induced decrease in locomotion. We also found that groups that received the combination of both modafinil and single dose METH showed a decrease in total distance traveled in an open field compared with METH groups. We observed an increment in the time mice expended doing stereotypic movements (continuous sniffing) in the group that received the combination of both METH and modafinil (i.e., decreasing locomotion). Our results suggest a possible protective role of modafinil against METH acute striatal toxicity. Synapse 2011. © 2011 Wiley-Liss, Inc. |
| title |
Attenuated methamphetamine induced neurotoxicity by modafinil administration in mice |
| title_short |
Attenuated methamphetamine induced neurotoxicity by modafinil administration in mice |
| title_full |
Attenuated methamphetamine induced neurotoxicity by modafinil administration in mice |
| title_fullStr |
Attenuated methamphetamine induced neurotoxicity by modafinil administration in mice |
| title_full_unstemmed |
Attenuated methamphetamine induced neurotoxicity by modafinil administration in mice |
| title_sort |
attenuated methamphetamine induced neurotoxicity by modafinil administration in mice |
| publishDate |
2011 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08874476_v65_n10_p1087_Raineri http://hdl.handle.net/20.500.12110/paper_08874476_v65_n10_p1087_Raineri |
| _version_ |
1768543090101977088 |