Altered synaptic synchrony in motor nerve terminals lacking P/Q-calcium channels
The variance in synaptic delays among endplate potentials events (referred here as jitter) was measured to study the contribution of voltage dependent calcium channels to transmission synchronicity in neuromuscular synapses from wild type and α-IA knockout mice (i.e., lacking P/Q type calcium channe...
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2008
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08874476_v62_n6_p466_Depetris http://hdl.handle.net/20.500.12110/paper_08874476_v62_n6_p466_Depetris |
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paper:paper_08874476_v62_n6_p466_Depetris2023-06-08T15:46:50Z Altered synaptic synchrony in motor nerve terminals lacking P/Q-calcium channels Calcium channels Knockout Mice N-type Neuromuscular junctions P/Q-type R-type calcium channel blocking agent calcium channel N type calcium channel P type calcium channel Q type calcium channel R type calcium ion neurotransmitter animal experiment article concentration response controlled study endplate potential extracellular calcium male mouse nerve ending neuromuscular synapse neurotransmission neurotransmitter release nonhuman priority journal receptor blocking synapse Animals Calcium Calcium Channel Blockers Calcium Channels, P-Type Calcium Channels, Q-Type Conotoxins Electric Stimulation Membrane Potentials Mice Mice, Knockout Neuromuscular Junction omega-Agatoxin IVA Presynaptic Terminals Synaptic Transmission The variance in synaptic delays among endplate potentials events (referred here as jitter) was measured to study the contribution of voltage dependent calcium channels to transmission synchronicity in neuromuscular synapses from wild type and α-IA knockout mice (i.e., lacking P/Q type calcium channels). Knockout synapses presented higher jitter values than wild type ones under a wide range of extracellular calcium concentration ([Ca 2+]0) values. Accordingly, wild type synapses showed less synchronic neurotransmitter release when P/Q type calcium channels were partially blocked as well as under lower [Ca2-]0. In the knockout synapses, N-type calcium channels mediated neurotransmitter release in a more temporally precise way than the R-type ones. Our results suggest that the type of calcium channels mediating transmitter release influenced the degree of synaptic synchrony. Thus, these results provide insight on the mechanisms underlying several pathologies associated with P/Q type calcium channels. ©2008 Wiley-Liss, Inc. 2008 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08874476_v62_n6_p466_Depetris http://hdl.handle.net/20.500.12110/paper_08874476_v62_n6_p466_Depetris |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Calcium channels Knockout Mice N-type Neuromuscular junctions P/Q-type R-type calcium channel blocking agent calcium channel N type calcium channel P type calcium channel Q type calcium channel R type calcium ion neurotransmitter animal experiment article concentration response controlled study endplate potential extracellular calcium male mouse nerve ending neuromuscular synapse neurotransmission neurotransmitter release nonhuman priority journal receptor blocking synapse Animals Calcium Calcium Channel Blockers Calcium Channels, P-Type Calcium Channels, Q-Type Conotoxins Electric Stimulation Membrane Potentials Mice Mice, Knockout Neuromuscular Junction omega-Agatoxin IVA Presynaptic Terminals Synaptic Transmission |
| spellingShingle |
Calcium channels Knockout Mice N-type Neuromuscular junctions P/Q-type R-type calcium channel blocking agent calcium channel N type calcium channel P type calcium channel Q type calcium channel R type calcium ion neurotransmitter animal experiment article concentration response controlled study endplate potential extracellular calcium male mouse nerve ending neuromuscular synapse neurotransmission neurotransmitter release nonhuman priority journal receptor blocking synapse Animals Calcium Calcium Channel Blockers Calcium Channels, P-Type Calcium Channels, Q-Type Conotoxins Electric Stimulation Membrane Potentials Mice Mice, Knockout Neuromuscular Junction omega-Agatoxin IVA Presynaptic Terminals Synaptic Transmission Altered synaptic synchrony in motor nerve terminals lacking P/Q-calcium channels |
| topic_facet |
Calcium channels Knockout Mice N-type Neuromuscular junctions P/Q-type R-type calcium channel blocking agent calcium channel N type calcium channel P type calcium channel Q type calcium channel R type calcium ion neurotransmitter animal experiment article concentration response controlled study endplate potential extracellular calcium male mouse nerve ending neuromuscular synapse neurotransmission neurotransmitter release nonhuman priority journal receptor blocking synapse Animals Calcium Calcium Channel Blockers Calcium Channels, P-Type Calcium Channels, Q-Type Conotoxins Electric Stimulation Membrane Potentials Mice Mice, Knockout Neuromuscular Junction omega-Agatoxin IVA Presynaptic Terminals Synaptic Transmission |
| description |
The variance in synaptic delays among endplate potentials events (referred here as jitter) was measured to study the contribution of voltage dependent calcium channels to transmission synchronicity in neuromuscular synapses from wild type and α-IA knockout mice (i.e., lacking P/Q type calcium channels). Knockout synapses presented higher jitter values than wild type ones under a wide range of extracellular calcium concentration ([Ca 2+]0) values. Accordingly, wild type synapses showed less synchronic neurotransmitter release when P/Q type calcium channels were partially blocked as well as under lower [Ca2-]0. In the knockout synapses, N-type calcium channels mediated neurotransmitter release in a more temporally precise way than the R-type ones. Our results suggest that the type of calcium channels mediating transmitter release influenced the degree of synaptic synchrony. Thus, these results provide insight on the mechanisms underlying several pathologies associated with P/Q type calcium channels. ©2008 Wiley-Liss, Inc. |
| title |
Altered synaptic synchrony in motor nerve terminals lacking P/Q-calcium channels |
| title_short |
Altered synaptic synchrony in motor nerve terminals lacking P/Q-calcium channels |
| title_full |
Altered synaptic synchrony in motor nerve terminals lacking P/Q-calcium channels |
| title_fullStr |
Altered synaptic synchrony in motor nerve terminals lacking P/Q-calcium channels |
| title_full_unstemmed |
Altered synaptic synchrony in motor nerve terminals lacking P/Q-calcium channels |
| title_sort |
altered synaptic synchrony in motor nerve terminals lacking p/q-calcium channels |
| publishDate |
2008 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08874476_v62_n6_p466_Depetris http://hdl.handle.net/20.500.12110/paper_08874476_v62_n6_p466_Depetris |
| _version_ |
1768543997817520128 |