Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability

Responsive interfacial architectures of practical interest commonly require the combination of conflicting properties in terms of their demand upon material structure. Switchable stiffness, wettability, and permeability, key features for tissue engineering applications, are in fact known to be exclu...

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Detalles Bibliográficos
Publicado:	2018
Materias:	Acrylic monomers Probes Stiffness Tissue engineering Wetting Adhesion properties Interconnected pores Interfacial architecture Lower critical solution temperature N- isopropylacrylamide Nanomechanical property Three dimensional arrays Tissue engineering applications Gels
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07437463_v34_n12_p3711_Maza http://hdl.handle.net/20.500.12110/paper_07437463_v34_n12_p3711_Maza
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_07437463_v34_n12_p3711_Maza
record_format	dspace
spelling	paper:paper_07437463_v34_n12_p3711_Maza2023-06-08T15:45:04Z Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability Acrylic monomers Probes Stiffness Tissue engineering Wetting Adhesion properties Interconnected pores Interfacial architecture Lower critical solution temperature N- isopropylacrylamide Nanomechanical property Three dimensional arrays Tissue engineering applications Gels Responsive interfacial architectures of practical interest commonly require the combination of conflicting properties in terms of their demand upon material structure. Switchable stiffness, wettability, and permeability, key features for tissue engineering applications, are in fact known to be exclusively interdependent. Here, we present a nanoarchitectonic approach that decouples these divergent properties by the use of thermoresponsive microgels as building blocks for the construction of three-dimensional arrays of interconnected pores. Layer-by-layer assembled poly(N-isopropylacrylamide-co-methacrylic acid) microgel films were found to exhibit an increase in hydrophobicity, stiffness, and adhesion properties upon switching the temperature from below to above the lower critical solution temperature, whereas the permeability of redox probes through the film remained unchanged. Our findings indicate that the switch in hydrophilicity and nanomechanical properties undergone by the microgels does not compromise the porosity of the film, thus allowing the free diffusion of redox probes through the polymer-free volume of the submicrometer pores. This novel approach for decoupling conflicting properties provides a strategic route for creating tailorable scaffolds with unforeseen functionalities. © 2018 American Chemical Society. 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07437463_v34_n12_p3711_Maza http://hdl.handle.net/20.500.12110/paper_07437463_v34_n12_p3711_Maza
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Acrylic monomers Probes Stiffness Tissue engineering Wetting Adhesion properties Interconnected pores Interfacial architecture Lower critical solution temperature N- isopropylacrylamide Nanomechanical property Three dimensional arrays Tissue engineering applications Gels
spellingShingle	Acrylic monomers Probes Stiffness Tissue engineering Wetting Adhesion properties Interconnected pores Interfacial architecture Lower critical solution temperature N- isopropylacrylamide Nanomechanical property Three dimensional arrays Tissue engineering applications Gels Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability
topic_facet	Acrylic monomers Probes Stiffness Tissue engineering Wetting Adhesion properties Interconnected pores Interfacial architecture Lower critical solution temperature N- isopropylacrylamide Nanomechanical property Three dimensional arrays Tissue engineering applications Gels
description	Responsive interfacial architectures of practical interest commonly require the combination of conflicting properties in terms of their demand upon material structure. Switchable stiffness, wettability, and permeability, key features for tissue engineering applications, are in fact known to be exclusively interdependent. Here, we present a nanoarchitectonic approach that decouples these divergent properties by the use of thermoresponsive microgels as building blocks for the construction of three-dimensional arrays of interconnected pores. Layer-by-layer assembled poly(N-isopropylacrylamide-co-methacrylic acid) microgel films were found to exhibit an increase in hydrophobicity, stiffness, and adhesion properties upon switching the temperature from below to above the lower critical solution temperature, whereas the permeability of redox probes through the film remained unchanged. Our findings indicate that the switch in hydrophilicity and nanomechanical properties undergone by the microgels does not compromise the porosity of the film, thus allowing the free diffusion of redox probes through the polymer-free volume of the submicrometer pores. This novel approach for decoupling conflicting properties provides a strategic route for creating tailorable scaffolds with unforeseen functionalities. © 2018 American Chemical Society.
title	Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability
title_short	Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability
title_full	Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability
title_fullStr	Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability
title_full_unstemmed	Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability
title_sort	layer-by-layer assembled microgels can combine conflicting properties: switchable stiffness and wettability without affecting permeability
publishDate	2018
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07437463_v34_n12_p3711_Maza http://hdl.handle.net/20.500.12110/paper_07437463_v34_n12_p3711_Maza
_version_	1768543806281482240

Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability

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