Lipid profiles as indicators of functional senescence in the medfly

Changes associated with the age-related decline of physiological functions, and their relation with mortality rates, are thoroughly being investigated in the aging research field. We used the Mediterranean fruit fly . Ceratitis capitata, largely studied by biodemographers, as a model for functional...

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Autores principales:	Pujol Lereis, Luciana Mercedes, Rabossi, Alejandro, Quesada Allué, Luis Alberto
Publicado:	2012
Materias:	Aging indicator Biodemography Ceratitis capitata Functional state Negative geotaxis Thermal stress abdomen age article controlled study demography Drosophila lifespan lipid analysis medfly Mediterranean fruit fly mortality nonhuman principal component analysis priority journal quantitative analysis senescence temperature stress thin layer chromatography thorax Abdomen Aging Animals Female Head Heat-Shock Response Lipid Metabolism Male Principal Component Analysis Survival Analysis Thorax Hexapoda
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_05315565_v47_n6_p465_PujolLereis http://hdl.handle.net/20.500.12110/paper_05315565_v47_n6_p465_PujolLereis
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_05315565_v47_n6_p465_PujolLereis
record_format	dspace
spelling	paper:paper_05315565_v47_n6_p465_PujolLereis2023-06-08T15:41:13Z Lipid profiles as indicators of functional senescence in the medfly Pujol Lereis, Luciana Mercedes Rabossi, Alejandro Quesada Allué, Luis Alberto Aging indicator Biodemography Ceratitis capitata Functional state Negative geotaxis Thermal stress abdomen age article controlled study demography Drosophila lifespan lipid analysis medfly Mediterranean fruit fly mortality nonhuman principal component analysis priority journal quantitative analysis senescence temperature stress thin layer chromatography thorax Abdomen Aging Animals Ceratitis capitata Female Head Heat-Shock Response Lipid Metabolism Male Principal Component Analysis Survival Analysis Thorax Ceratitis capitata Hexapoda Changes associated with the age-related decline of physiological functions, and their relation with mortality rates, are thoroughly being investigated in the aging research field. We used the Mediterranean fruit fly . Ceratitis capitata, largely studied by biodemographers, as a model for functional senescence studies. The aim of our work was to find novel combinatorial indicators able to reflect the functional state of adult insects, regardless of chronological age. We studied the profiles of neutral and polar lipids of head, thorax and abdomen of standard populations kept at 23. °C, at different ages. Lipid classes were separated by thin layer chromatography, and the quantitative values were used to find patterns of change using a multivariate principal component analysis approach. The lipid-dependent principal components obtained correlated with age, and differences between sexes were consistent with differences in the shape of the survival curves and the mortality parameters. These same components were able to discriminate populations with a behavioral decline due to a mild 28. °C thermal stress. Thus, young populations at 28. °C showed similar lipid profiles than old populations at 23. °C. The results indicated that the lipid-dependent components reflect the functional state of the flies, and so were named functional state components (FSCs). It is proposed that FSCs may be used as functional senescence indicators. © 2012 Elsevier Inc. Fil:Pujol-Lereis, L.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rabossi, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Quesada-Allué, L.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_05315565_v47_n6_p465_PujolLereis http://hdl.handle.net/20.500.12110/paper_05315565_v47_n6_p465_PujolLereis
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Aging indicator Biodemography Ceratitis capitata Functional state Negative geotaxis Thermal stress abdomen age article controlled study demography Drosophila lifespan lipid analysis medfly Mediterranean fruit fly mortality nonhuman principal component analysis priority journal quantitative analysis senescence temperature stress thin layer chromatography thorax Abdomen Aging Animals Ceratitis capitata Female Head Heat-Shock Response Lipid Metabolism Male Principal Component Analysis Survival Analysis Thorax Ceratitis capitata Hexapoda
spellingShingle	Aging indicator Biodemography Ceratitis capitata Functional state Negative geotaxis Thermal stress abdomen age article controlled study demography Drosophila lifespan lipid analysis medfly Mediterranean fruit fly mortality nonhuman principal component analysis priority journal quantitative analysis senescence temperature stress thin layer chromatography thorax Abdomen Aging Animals Ceratitis capitata Female Head Heat-Shock Response Lipid Metabolism Male Principal Component Analysis Survival Analysis Thorax Ceratitis capitata Hexapoda Pujol Lereis, Luciana Mercedes Rabossi, Alejandro Quesada Allué, Luis Alberto Lipid profiles as indicators of functional senescence in the medfly
topic_facet	Aging indicator Biodemography Ceratitis capitata Functional state Negative geotaxis Thermal stress abdomen age article controlled study demography Drosophila lifespan lipid analysis medfly Mediterranean fruit fly mortality nonhuman principal component analysis priority journal quantitative analysis senescence temperature stress thin layer chromatography thorax Abdomen Aging Animals Ceratitis capitata Female Head Heat-Shock Response Lipid Metabolism Male Principal Component Analysis Survival Analysis Thorax Ceratitis capitata Hexapoda
description	Changes associated with the age-related decline of physiological functions, and their relation with mortality rates, are thoroughly being investigated in the aging research field. We used the Mediterranean fruit fly . Ceratitis capitata, largely studied by biodemographers, as a model for functional senescence studies. The aim of our work was to find novel combinatorial indicators able to reflect the functional state of adult insects, regardless of chronological age. We studied the profiles of neutral and polar lipids of head, thorax and abdomen of standard populations kept at 23. °C, at different ages. Lipid classes were separated by thin layer chromatography, and the quantitative values were used to find patterns of change using a multivariate principal component analysis approach. The lipid-dependent principal components obtained correlated with age, and differences between sexes were consistent with differences in the shape of the survival curves and the mortality parameters. These same components were able to discriminate populations with a behavioral decline due to a mild 28. °C thermal stress. Thus, young populations at 28. °C showed similar lipid profiles than old populations at 23. °C. The results indicated that the lipid-dependent components reflect the functional state of the flies, and so were named functional state components (FSCs). It is proposed that FSCs may be used as functional senescence indicators. © 2012 Elsevier Inc.
author	Pujol Lereis, Luciana Mercedes Rabossi, Alejandro Quesada Allué, Luis Alberto
author_facet	Pujol Lereis, Luciana Mercedes Rabossi, Alejandro Quesada Allué, Luis Alberto
author_sort	Pujol Lereis, Luciana Mercedes
title	Lipid profiles as indicators of functional senescence in the medfly
title_short	Lipid profiles as indicators of functional senescence in the medfly
title_full	Lipid profiles as indicators of functional senescence in the medfly
title_fullStr	Lipid profiles as indicators of functional senescence in the medfly
title_full_unstemmed	Lipid profiles as indicators of functional senescence in the medfly
title_sort	lipid profiles as indicators of functional senescence in the medfly
publishDate	2012
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_05315565_v47_n6_p465_PujolLereis http://hdl.handle.net/20.500.12110/paper_05315565_v47_n6_p465_PujolLereis
work_keys_str_mv	AT pujollereislucianamercedes lipidprofilesasindicatorsoffunctionalsenescenceinthemedfly AT rabossialejandro lipidprofilesasindicatorsoffunctionalsenescenceinthemedfly AT quesadaallueluisalberto lipidprofilesasindicatorsoffunctionalsenescenceinthemedfly
_version_	1768544369458020352

Lipid profiles as indicators of functional senescence in the medfly

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