Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes
Novel interpolyelectrolyte complexes (IPECs) between naturally sulfated polysaccharides of the seaweed Polysiphonia nigrescens (PN) and cationized agaroses (CAG) and Eudragit E (EE) were prepared using an organic solvent free process, characterized, and explored for controlled drug release. Tablets...
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2012
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03785173_v429_n1-2_p12_Prado http://hdl.handle.net/20.500.12110/paper_03785173_v429_n1-2_p12_Prado |
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paper:paper_03785173_v429_n1-2_p12_Prado2023-06-08T15:40:22Z Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes Prado, Héctor Juan Matulewicz, María Cristina Bonelli, Pablo R. Cukierman, Ana Lea Cationized agarose Controlled drug release Eudragit E Interpolyelectrolyte complexes (IPECs) Polysiphonia nigrescens agarose eudragit eudragit rs ibuprofen organic solvent article drug release molecular weight nonhuman priority journal seaweed solubility tablet Delayed-Action Preparations Diffusion Drug Compounding Electrolytes Excipients Ibuprofen Molecular Weight Polymers Polymethacrylic Acids Polysaccharides Seaweed Sepharose Solubility Tablets Novel interpolyelectrolyte complexes (IPECs) between naturally sulfated polysaccharides of the seaweed Polysiphonia nigrescens (PN) and cationized agaroses (CAG) and Eudragit E (EE) were prepared using an organic solvent free process, characterized, and explored for controlled drug release. Tablets containing model drug ibuprofen and IPECs were prepared by direct compression. Drug release in acid medium was low owing to the low solubility of ibuprofen in that condition and to the matrix action. Zero order drug release was determined in the buffer stage (pH = 6.8), with Fickian diffusion predominating over relaxation during the initial phases. Relaxation appears to increase along the release process and even overcomes diffusion for some systems. Drug release profiles could be controlled by varying the content of IPECs in the tablets. Also, the change in molecular weight and the degree of substitution of the components allowed altering the release profiles. © 2012 Elsevier B.V. Fil:Prado, H.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Matulewicz, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bonelli, P.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cukierman, A.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03785173_v429_n1-2_p12_Prado http://hdl.handle.net/20.500.12110/paper_03785173_v429_n1-2_p12_Prado |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cationized agarose Controlled drug release Eudragit E Interpolyelectrolyte complexes (IPECs) Polysiphonia nigrescens agarose eudragit eudragit rs ibuprofen organic solvent article drug release molecular weight nonhuman priority journal seaweed solubility tablet Delayed-Action Preparations Diffusion Drug Compounding Electrolytes Excipients Ibuprofen Molecular Weight Polymers Polymethacrylic Acids Polysaccharides Seaweed Sepharose Solubility Tablets |
| spellingShingle |
Cationized agarose Controlled drug release Eudragit E Interpolyelectrolyte complexes (IPECs) Polysiphonia nigrescens agarose eudragit eudragit rs ibuprofen organic solvent article drug release molecular weight nonhuman priority journal seaweed solubility tablet Delayed-Action Preparations Diffusion Drug Compounding Electrolytes Excipients Ibuprofen Molecular Weight Polymers Polymethacrylic Acids Polysaccharides Seaweed Sepharose Solubility Tablets Prado, Héctor Juan Matulewicz, María Cristina Bonelli, Pablo R. Cukierman, Ana Lea Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes |
| topic_facet |
Cationized agarose Controlled drug release Eudragit E Interpolyelectrolyte complexes (IPECs) Polysiphonia nigrescens agarose eudragit eudragit rs ibuprofen organic solvent article drug release molecular weight nonhuman priority journal seaweed solubility tablet Delayed-Action Preparations Diffusion Drug Compounding Electrolytes Excipients Ibuprofen Molecular Weight Polymers Polymethacrylic Acids Polysaccharides Seaweed Sepharose Solubility Tablets |
| description |
Novel interpolyelectrolyte complexes (IPECs) between naturally sulfated polysaccharides of the seaweed Polysiphonia nigrescens (PN) and cationized agaroses (CAG) and Eudragit E (EE) were prepared using an organic solvent free process, characterized, and explored for controlled drug release. Tablets containing model drug ibuprofen and IPECs were prepared by direct compression. Drug release in acid medium was low owing to the low solubility of ibuprofen in that condition and to the matrix action. Zero order drug release was determined in the buffer stage (pH = 6.8), with Fickian diffusion predominating over relaxation during the initial phases. Relaxation appears to increase along the release process and even overcomes diffusion for some systems. Drug release profiles could be controlled by varying the content of IPECs in the tablets. Also, the change in molecular weight and the degree of substitution of the components allowed altering the release profiles. © 2012 Elsevier B.V. |
| author |
Prado, Héctor Juan Matulewicz, María Cristina Bonelli, Pablo R. Cukierman, Ana Lea |
| author_facet |
Prado, Héctor Juan Matulewicz, María Cristina Bonelli, Pablo R. Cukierman, Ana Lea |
| author_sort |
Prado, Héctor Juan |
| title |
Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes |
| title_short |
Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes |
| title_full |
Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes |
| title_fullStr |
Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes |
| title_full_unstemmed |
Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes |
| title_sort |
preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03785173_v429_n1-2_p12_Prado http://hdl.handle.net/20.500.12110/paper_03785173_v429_n1-2_p12_Prado |
| work_keys_str_mv |
AT pradohectorjuan preparationandcharacterizationofcontrolledreleasematricesbasedonnovelseaweedinterpolyelectrolytecomplexes AT matulewiczmariacristina preparationandcharacterizationofcontrolledreleasematricesbasedonnovelseaweedinterpolyelectrolytecomplexes AT bonellipablor preparationandcharacterizationofcontrolledreleasematricesbasedonnovelseaweedinterpolyelectrolytecomplexes AT cukiermananalea preparationandcharacterizationofcontrolledreleasematricesbasedonnovelseaweedinterpolyelectrolytecomplexes |
| _version_ |
1768542555256913920 |