DNA single strand breaks in peripheral blood lymphocytes induced by three nitroimidazole derivatives

Tinidazole (TNZ), ornidazole (ONZ) and metronidazole (MTZ) are antiparasitic drugs (nitroimidazole derivatives) that have proven to be effective against Trichomonas vaginalis, Entoamoeba histolytica, Giardia lamblia and Helicobacter pylori. The reduction of the nitro group and the generation of shor...

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Detalles Bibliográficos
Publicado:	2002
Materias:	Comet assay DNA damage Metronidazole Nitroimidazoles Ornidazole Tinidazole DNA metronidazole nitroimidazole derivative ornidazole reactive oxygen metabolite tinidazole aerobic metabolism antimicrobial activity article bacterial cell comet assay concentration response controlled study DNA strand breakage drug cytotoxicity human human cell lymphocyte mammal cell mutagenic activity priority journal Adult Antitrichomonal Agents Cells, Cultured Comet Assay DNA Damage DNA, Single-Stranded Dose-Response Relationship, Drug Humans Lymphocytes Male Giardia Giardia intestinalis Helicobacter Helicobacter pylori Mammalia Trichomonas vaginalis
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03784274_v132_n2_p109_RodriguezFerreiro http://hdl.handle.net/20.500.12110/paper_03784274_v132_n2_p109_RodriguezFerreiro
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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