Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle
The neuregulin receptor tyrosine kinase Erb-b4, initially linked to early cardiac development, is shown here to play a critical role in adult cardiac function. In wild-type mice, Erb-b4 protein localized to Z lines and to intercalated disks, suggesting a role in subcellular and intercellular communi...
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2005
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03636135_v289_n358-3_pH1153_GarciaRivello http://hdl.handle.net/20.500.12110/paper_03636135_v289_n358-3_pH1153_GarciaRivello |
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paper:paper_03636135_v289_n358-3_pH1153_GarciaRivello2023-06-08T15:35:28Z Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle Conditional knockout erb-b2 Heart Mouse Neuregulin actin atrial natriuretic factor brain natriuretic peptide cre recombinase epidermal growth factor receptor 4 indo 1 myosin light chain animal experiment animal model animal tissue article cell communication cellular distribution congestive cardiomyopathy controlled study electrocardiography female gene inactivation gene targeting heart development heart muscle cell heart muscle contractility heart ventricle hypertrophy heterozygosity histochemistry immunofluorescence knockout mouse mouse nick end labeling nonhuman priority journal reverse transcription polymerase chain reaction Western blotting wild type Animals Cardiomegaly Cardiomyopathy, Dilated Disease Models, Animal Female Male Mice Mice, Inbred C57BL Mice, Knockout Myocardial Contraction Myocardium Receptor, Epidermal Growth Factor Signal Transduction The neuregulin receptor tyrosine kinase Erb-b4, initially linked to early cardiac development, is shown here to play a critical role in adult cardiac function. In wild-type mice, Erb-b4 protein localized to Z lines and to intercalated disks, suggesting a role in subcellular and intercellular communications of cardiomyocytes. Conditional inactivation of erb-b4 in ventricular muscle cells led to a severe dilated cardiomyopathy, characterized by thinned ventricular walls with eccentric hypertrophy, reduced contractility, and delayed conduction. This cardiac dysfunction may account for premature death in adult erb-b4-knockout mice. This study establishes a critical role for Erb-b4 in the maintenance of normal postnatal cardiac structure and function. Copyright © 2005 the American Physiological Society. 2005 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03636135_v289_n358-3_pH1153_GarciaRivello http://hdl.handle.net/20.500.12110/paper_03636135_v289_n358-3_pH1153_GarciaRivello |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Conditional knockout erb-b2 Heart Mouse Neuregulin actin atrial natriuretic factor brain natriuretic peptide cre recombinase epidermal growth factor receptor 4 indo 1 myosin light chain animal experiment animal model animal tissue article cell communication cellular distribution congestive cardiomyopathy controlled study electrocardiography female gene inactivation gene targeting heart development heart muscle cell heart muscle contractility heart ventricle hypertrophy heterozygosity histochemistry immunofluorescence knockout mouse mouse nick end labeling nonhuman priority journal reverse transcription polymerase chain reaction Western blotting wild type Animals Cardiomegaly Cardiomyopathy, Dilated Disease Models, Animal Female Male Mice Mice, Inbred C57BL Mice, Knockout Myocardial Contraction Myocardium Receptor, Epidermal Growth Factor Signal Transduction |
| spellingShingle |
Conditional knockout erb-b2 Heart Mouse Neuregulin actin atrial natriuretic factor brain natriuretic peptide cre recombinase epidermal growth factor receptor 4 indo 1 myosin light chain animal experiment animal model animal tissue article cell communication cellular distribution congestive cardiomyopathy controlled study electrocardiography female gene inactivation gene targeting heart development heart muscle cell heart muscle contractility heart ventricle hypertrophy heterozygosity histochemistry immunofluorescence knockout mouse mouse nick end labeling nonhuman priority journal reverse transcription polymerase chain reaction Western blotting wild type Animals Cardiomegaly Cardiomyopathy, Dilated Disease Models, Animal Female Male Mice Mice, Inbred C57BL Mice, Knockout Myocardial Contraction Myocardium Receptor, Epidermal Growth Factor Signal Transduction Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle |
| topic_facet |
Conditional knockout erb-b2 Heart Mouse Neuregulin actin atrial natriuretic factor brain natriuretic peptide cre recombinase epidermal growth factor receptor 4 indo 1 myosin light chain animal experiment animal model animal tissue article cell communication cellular distribution congestive cardiomyopathy controlled study electrocardiography female gene inactivation gene targeting heart development heart muscle cell heart muscle contractility heart ventricle hypertrophy heterozygosity histochemistry immunofluorescence knockout mouse mouse nick end labeling nonhuman priority journal reverse transcription polymerase chain reaction Western blotting wild type Animals Cardiomegaly Cardiomyopathy, Dilated Disease Models, Animal Female Male Mice Mice, Inbred C57BL Mice, Knockout Myocardial Contraction Myocardium Receptor, Epidermal Growth Factor Signal Transduction |
| description |
The neuregulin receptor tyrosine kinase Erb-b4, initially linked to early cardiac development, is shown here to play a critical role in adult cardiac function. In wild-type mice, Erb-b4 protein localized to Z lines and to intercalated disks, suggesting a role in subcellular and intercellular communications of cardiomyocytes. Conditional inactivation of erb-b4 in ventricular muscle cells led to a severe dilated cardiomyopathy, characterized by thinned ventricular walls with eccentric hypertrophy, reduced contractility, and delayed conduction. This cardiac dysfunction may account for premature death in adult erb-b4-knockout mice. This study establishes a critical role for Erb-b4 in the maintenance of normal postnatal cardiac structure and function. Copyright © 2005 the American Physiological Society. |
| title |
Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle |
| title_short |
Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle |
| title_full |
Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle |
| title_fullStr |
Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle |
| title_full_unstemmed |
Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle |
| title_sort |
dilated cardiomyopathy in erb-b4-deficient ventricular muscle |
| publishDate |
2005 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03636135_v289_n358-3_pH1153_GarciaRivello http://hdl.handle.net/20.500.12110/paper_03636135_v289_n358-3_pH1153_GarciaRivello |
| _version_ |
1768543802602029056 |