Synthesis of [20,21‐13C2]‐pregnenolone

The synthesis of [20,21‐13C2]‐pregnenolone (7) from androst‐5‐en‐3β‐ol‐17‐one (1) is described. Labelled carbons were introduced by two procedures, namely, condensation of 1 with K13CN and Grignard reaction of nitrile derivative 5 with [13C]‐methylmagnesium iodide. Location of labels was confirmed b...

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Detalles Bibliográficos
Autores principales:	Caballero, Gerardo Manuel, Gros, Eduardo Gervasio
Publicado:	1993
Materias:	synthesis [20,21‐13C2]‐pregnenolone carbon 13 pregnenolone article controlled study drug synthesis isotope labeling
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03624803_v33_n10_p907_Caballero http://hdl.handle.net/20.500.12110/paper_03624803_v33_n10_p907_Caballero
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03624803_v33_n10_p907_Caballero
record_format	dspace
spelling	paper:paper_03624803_v33_n10_p907_Caballero2023-06-08T15:35:10Z Synthesis of [20,21‐13C2]‐pregnenolone Caballero, Gerardo Manuel Gros, Eduardo Gervasio synthesis [20,21‐13C2]‐pregnenolone carbon 13 pregnenolone article controlled study drug synthesis isotope labeling The synthesis of [20,21‐13C2]‐pregnenolone (7) from androst‐5‐en‐3β‐ol‐17‐one (1) is described. Labelled carbons were introduced by two procedures, namely, condensation of 1 with K13CN and Grignard reaction of nitrile derivative 5 with [13C]‐methylmagnesium iodide. Location of labels was confirmed by 13C‐NMR spectroscopy. Copyright © 1993 John Wiley & Sons, Ltd. Fil:Caballero, G.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gros, E.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1993 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03624803_v33_n10_p907_Caballero http://hdl.handle.net/20.500.12110/paper_03624803_v33_n10_p907_Caballero
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	synthesis [20,21‐13C2]‐pregnenolone carbon 13 pregnenolone article controlled study drug synthesis isotope labeling
spellingShingle	synthesis [20,21‐13C2]‐pregnenolone carbon 13 pregnenolone article controlled study drug synthesis isotope labeling Caballero, Gerardo Manuel Gros, Eduardo Gervasio Synthesis of [20,21‐13C2]‐pregnenolone
topic_facet	synthesis [20,21‐13C2]‐pregnenolone carbon 13 pregnenolone article controlled study drug synthesis isotope labeling
description	The synthesis of [20,21‐13C2]‐pregnenolone (7) from androst‐5‐en‐3β‐ol‐17‐one (1) is described. Labelled carbons were introduced by two procedures, namely, condensation of 1 with K13CN and Grignard reaction of nitrile derivative 5 with [13C]‐methylmagnesium iodide. Location of labels was confirmed by 13C‐NMR spectroscopy. Copyright © 1993 John Wiley & Sons, Ltd.
author	Caballero, Gerardo Manuel Gros, Eduardo Gervasio
author_facet	Caballero, Gerardo Manuel Gros, Eduardo Gervasio
author_sort	Caballero, Gerardo Manuel
title	Synthesis of [20,21‐13C2]‐pregnenolone
title_short	Synthesis of [20,21‐13C2]‐pregnenolone
title_full	Synthesis of [20,21‐13C2]‐pregnenolone
title_fullStr	Synthesis of [20,21‐13C2]‐pregnenolone
title_full_unstemmed	Synthesis of [20,21‐13C2]‐pregnenolone
title_sort	synthesis of [20,21‐13c2]‐pregnenolone
publishDate	1993
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03624803_v33_n10_p907_Caballero http://hdl.handle.net/20.500.12110/paper_03624803_v33_n10_p907_Caballero
work_keys_str_mv	AT caballerogerardomanuel synthesisof202113c2pregnenolone AT groseduardogervasio synthesisof202113c2pregnenolone
_version_	1768543611307163648

Synthesis of [20,21‐13C2]‐pregnenolone

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