Premotor nonspiking neurons regulate coupling among motoneurons that innervate overlapping muscle fiber population

Recent work indicated that co-activity of different motoneurons (MNs) in the leech can be regulated through a network that is centered on a pair of nonspiking (NS) neurons. Here, we investigate whether this effect generalizes to different types of MNs that display differential co-activity patterns i...

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Autores principales: Rodríguez, Mariano Julián, Perez Etchegoyen, C. Bernardo, Szczupak, Lidia
Publicado: 2009
Materias:
Electrical coupling
Leech
Motor circuits
Nonspiking neuron
Rectifying junctions
animal
article
classification
ganglion
innervation
leech
motoneuron
muscle
nerve cell
patch clamp
physiology
synapse
synaptic transmission
Animals
Ganglia, Invertebrate
Leeches
Motor Neurons
Muscles
Neurons
Patch-Clamp Techniques
Synapses
Synaptic Transmission
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03407594_v195_n5_p491_Rodriguez
http://hdl.handle.net/20.500.12110/paper_03407594_v195_n5_p491_Rodriguez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_03407594_v195_n5_p491_Rodriguez
record_format dspace
spelling paper:paper_03407594_v195_n5_p491_Rodriguez2023-06-08T15:34:23Z Premotor nonspiking neurons regulate coupling among motoneurons that innervate overlapping muscle fiber population Rodríguez, Mariano Julián Perez Etchegoyen, C. Bernardo Szczupak, Lidia Electrical coupling Leech Motor circuits Nonspiking neuron Rectifying junctions animal article classification ganglion innervation leech motoneuron muscle nerve cell patch clamp physiology synapse synaptic transmission Animals Ganglia, Invertebrate Leeches Motor Neurons Muscles Neurons Patch-Clamp Techniques Synapses Synaptic Transmission Recent work indicated that co-activity of different motoneurons (MNs) in the leech can be regulated through a network that is centered on a pair of nonspiking (NS) neurons. Here, we investigate whether this effect generalizes to different types of MNs that display differential co-activity patterns in different motor behaviors: the dorsal longitudinal excitors DE-3 and the dorsal and ventral excitors MN-L. The data indicates that both motoneurons are coupled to the NS neurons through rectifying junctions that are activated when the motoneuron membrane potential becomes more negative than that of the NS, and that they exert an inhibitory synaptic potential on NS via a polysynaptic pathway. In addition, DE-3 and MN-L are linked by junctions that allow mutual excitation but the transmission of excitatory signals from MN-L to DE-3 depended on NS membrane potential. The results support the view that NS neurons can play a central role in orchestrating the co-activity of MNs during motor behaviors. © 2009 Springer-Verlag. Fil:Rodriguez, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Perez-Etchegoyen, C.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Szczupak, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03407594_v195_n5_p491_Rodriguez http://hdl.handle.net/20.500.12110/paper_03407594_v195_n5_p491_Rodriguez
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Electrical coupling
Leech
Motor circuits
Nonspiking neuron
Rectifying junctions
animal
article
classification
ganglion
innervation
leech
motoneuron
muscle
nerve cell
patch clamp
physiology
synapse
synaptic transmission
Animals
Ganglia, Invertebrate
Leeches
Motor Neurons
Muscles
Neurons
Patch-Clamp Techniques
Synapses
Synaptic Transmission
spellingShingle Electrical coupling
Leech
Motor circuits
Nonspiking neuron
Rectifying junctions
animal
article
classification
ganglion
innervation
leech
motoneuron
muscle
nerve cell
patch clamp
physiology
synapse
synaptic transmission
Animals
Ganglia, Invertebrate
Leeches
Motor Neurons
Muscles
Neurons
Patch-Clamp Techniques
Synapses
Synaptic Transmission
Rodríguez, Mariano Julián
Perez Etchegoyen, C. Bernardo
Szczupak, Lidia
Premotor nonspiking neurons regulate coupling among motoneurons that innervate overlapping muscle fiber population
topic_facet Electrical coupling
Leech
Motor circuits
Nonspiking neuron
Rectifying junctions
animal
article
classification
ganglion
innervation
leech
motoneuron
muscle
nerve cell
patch clamp
physiology
synapse
synaptic transmission
Animals
Ganglia, Invertebrate
Leeches
Motor Neurons
Muscles
Neurons
Patch-Clamp Techniques
Synapses
Synaptic Transmission
description Recent work indicated that co-activity of different motoneurons (MNs) in the leech can be regulated through a network that is centered on a pair of nonspiking (NS) neurons. Here, we investigate whether this effect generalizes to different types of MNs that display differential co-activity patterns in different motor behaviors: the dorsal longitudinal excitors DE-3 and the dorsal and ventral excitors MN-L. The data indicates that both motoneurons are coupled to the NS neurons through rectifying junctions that are activated when the motoneuron membrane potential becomes more negative than that of the NS, and that they exert an inhibitory synaptic potential on NS via a polysynaptic pathway. In addition, DE-3 and MN-L are linked by junctions that allow mutual excitation but the transmission of excitatory signals from MN-L to DE-3 depended on NS membrane potential. The results support the view that NS neurons can play a central role in orchestrating the co-activity of MNs during motor behaviors. © 2009 Springer-Verlag.
author Rodríguez, Mariano Julián
Perez Etchegoyen, C. Bernardo
Szczupak, Lidia
author_facet Rodríguez, Mariano Julián
Perez Etchegoyen, C. Bernardo
Szczupak, Lidia
author_sort Rodríguez, Mariano Julián
title Premotor nonspiking neurons regulate coupling among motoneurons that innervate overlapping muscle fiber population
title_short Premotor nonspiking neurons regulate coupling among motoneurons that innervate overlapping muscle fiber population
title_full Premotor nonspiking neurons regulate coupling among motoneurons that innervate overlapping muscle fiber population
title_fullStr Premotor nonspiking neurons regulate coupling among motoneurons that innervate overlapping muscle fiber population
title_full_unstemmed Premotor nonspiking neurons regulate coupling among motoneurons that innervate overlapping muscle fiber population
title_sort premotor nonspiking neurons regulate coupling among motoneurons that innervate overlapping muscle fiber population
publishDate 2009
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03407594_v195_n5_p491_Rodriguez
http://hdl.handle.net/20.500.12110/paper_03407594_v195_n5_p491_Rodriguez
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AT perezetchegoyencbernardo premotornonspikingneuronsregulatecouplingamongmotoneuronsthatinnervateoverlappingmusclefiberpopulation
AT szczupaklidia premotornonspikingneuronsregulatecouplingamongmotoneuronsthatinnervateoverlappingmusclefiberpopulation
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