Immunizations and risk of multiple sclerosis: Systematic review and meta-analysis
The role of vaccinations in risk of developing multiple sclerosis (MS) or in risk of relapse has not been well established. The aim of this study was to estimate the effect of immunizations on risk of developing MS in adults as well as in subsequent risk of relapse. Systematic search for publication...
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2011
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03405354_v258_n7_p1197_Farez http://hdl.handle.net/20.500.12110/paper_03405354_v258_n7_p1197_Farez |
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paper:paper_03405354_v258_n7_p1197_Farez2023-06-08T15:33:58Z Immunizations and risk of multiple sclerosis: Systematic review and meta-analysis Meta-analysis Multiple sclerosis Systematic review Vaccines BCG vaccine chickenpox vaccine diphtheria pertussis tetanus vaccine diphtheria toxoid hepatitis A vaccine hepatitis B vaccine influenza vaccine measles mumps rubella vaccine poliomyelitis vaccine tetanus toxoid typhoid vaccine BCG vaccination chickenpox data base diphtheria drug efficacy hepatitis A hepatitis B human immunization influenza influenza vaccination measles measles vaccination meta analysis multiple sclerosis mumps outcome assessment pertussis poliomyelitis priority journal randomized controlled trial (topic) relapse review risk factor rubella systematic review tetanus tetanus prophylaxis treatment outcome tuberculosis typhoid fever Humans Immunization Multiple Sclerosis Risk The role of vaccinations in risk of developing multiple sclerosis (MS) or in risk of relapse has not been well established. The aim of this study was to estimate the effect of immunizations on risk of developing MS in adults as well as in subsequent risk of relapse. Systematic search for publications in MEDLINE (1966-January 2011), EMBASE (1977-January 2011) and the Cochrane Central Register of Controlled Trials (CENTRAL) (1961-January 2011). Both randomized clinical trials and non-randomized studies addressing the effect of any Center for Diseases Control (CDC) recommended vaccine for children, adults or travelers and BCG on risk of MS or disease relapse were included. Two reviewers independently extracted information from articles selected using a predefined datasheet. No significant change in the risk of developing MS after vaccination was found for BCG (OR 0.96, 95% CI 0.69-1.34), Hepatitis B (OR 1.00, 95% CI 0.74-1.37), Influenza (OR 0.97, 95% CI 0.77-1.23), Measles-Mumps-Rubella (MMR) (OR 1.02, 95% CI 0.64-1.61), Polio (OR 0.87, 95% CI 0.61-1.25) and Typhoid fever (OR 1.05, 95% CI 0.72-1.53). We found decreased risk of developing MS for Diphtheria (OR 0.60, 95% CI 0.40-0.90) and Tetanus (OR 0.68, 95% CI 0.54-0.84). Influenza immunization was also associated with no change in risk of MS relapse (RR 1.24, 95% CI 0.89-1.72). Risk of developing multiple sclerosis remained unchanged after BCG, Hepatitis B, Influenza, MMR, Polio and Typhoid fever immunization, whereas diphtheria and tetanus vaccination may be associated with a decreased risk of MS. Further research is needed for the remaining vaccines. © 2011 Springer-Verlag. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03405354_v258_n7_p1197_Farez http://hdl.handle.net/20.500.12110/paper_03405354_v258_n7_p1197_Farez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Meta-analysis Multiple sclerosis Systematic review Vaccines BCG vaccine chickenpox vaccine diphtheria pertussis tetanus vaccine diphtheria toxoid hepatitis A vaccine hepatitis B vaccine influenza vaccine measles mumps rubella vaccine poliomyelitis vaccine tetanus toxoid typhoid vaccine BCG vaccination chickenpox data base diphtheria drug efficacy hepatitis A hepatitis B human immunization influenza influenza vaccination measles measles vaccination meta analysis multiple sclerosis mumps outcome assessment pertussis poliomyelitis priority journal randomized controlled trial (topic) relapse review risk factor rubella systematic review tetanus tetanus prophylaxis treatment outcome tuberculosis typhoid fever Humans Immunization Multiple Sclerosis Risk |
| spellingShingle |
Meta-analysis Multiple sclerosis Systematic review Vaccines BCG vaccine chickenpox vaccine diphtheria pertussis tetanus vaccine diphtheria toxoid hepatitis A vaccine hepatitis B vaccine influenza vaccine measles mumps rubella vaccine poliomyelitis vaccine tetanus toxoid typhoid vaccine BCG vaccination chickenpox data base diphtheria drug efficacy hepatitis A hepatitis B human immunization influenza influenza vaccination measles measles vaccination meta analysis multiple sclerosis mumps outcome assessment pertussis poliomyelitis priority journal randomized controlled trial (topic) relapse review risk factor rubella systematic review tetanus tetanus prophylaxis treatment outcome tuberculosis typhoid fever Humans Immunization Multiple Sclerosis Risk Immunizations and risk of multiple sclerosis: Systematic review and meta-analysis |
| topic_facet |
Meta-analysis Multiple sclerosis Systematic review Vaccines BCG vaccine chickenpox vaccine diphtheria pertussis tetanus vaccine diphtheria toxoid hepatitis A vaccine hepatitis B vaccine influenza vaccine measles mumps rubella vaccine poliomyelitis vaccine tetanus toxoid typhoid vaccine BCG vaccination chickenpox data base diphtheria drug efficacy hepatitis A hepatitis B human immunization influenza influenza vaccination measles measles vaccination meta analysis multiple sclerosis mumps outcome assessment pertussis poliomyelitis priority journal randomized controlled trial (topic) relapse review risk factor rubella systematic review tetanus tetanus prophylaxis treatment outcome tuberculosis typhoid fever Humans Immunization Multiple Sclerosis Risk |
| description |
The role of vaccinations in risk of developing multiple sclerosis (MS) or in risk of relapse has not been well established. The aim of this study was to estimate the effect of immunizations on risk of developing MS in adults as well as in subsequent risk of relapse. Systematic search for publications in MEDLINE (1966-January 2011), EMBASE (1977-January 2011) and the Cochrane Central Register of Controlled Trials (CENTRAL) (1961-January 2011). Both randomized clinical trials and non-randomized studies addressing the effect of any Center for Diseases Control (CDC) recommended vaccine for children, adults or travelers and BCG on risk of MS or disease relapse were included. Two reviewers independently extracted information from articles selected using a predefined datasheet. No significant change in the risk of developing MS after vaccination was found for BCG (OR 0.96, 95% CI 0.69-1.34), Hepatitis B (OR 1.00, 95% CI 0.74-1.37), Influenza (OR 0.97, 95% CI 0.77-1.23), Measles-Mumps-Rubella (MMR) (OR 1.02, 95% CI 0.64-1.61), Polio (OR 0.87, 95% CI 0.61-1.25) and Typhoid fever (OR 1.05, 95% CI 0.72-1.53). We found decreased risk of developing MS for Diphtheria (OR 0.60, 95% CI 0.40-0.90) and Tetanus (OR 0.68, 95% CI 0.54-0.84). Influenza immunization was also associated with no change in risk of MS relapse (RR 1.24, 95% CI 0.89-1.72). Risk of developing multiple sclerosis remained unchanged after BCG, Hepatitis B, Influenza, MMR, Polio and Typhoid fever immunization, whereas diphtheria and tetanus vaccination may be associated with a decreased risk of MS. Further research is needed for the remaining vaccines. © 2011 Springer-Verlag. |
| title |
Immunizations and risk of multiple sclerosis: Systematic review and meta-analysis |
| title_short |
Immunizations and risk of multiple sclerosis: Systematic review and meta-analysis |
| title_full |
Immunizations and risk of multiple sclerosis: Systematic review and meta-analysis |
| title_fullStr |
Immunizations and risk of multiple sclerosis: Systematic review and meta-analysis |
| title_full_unstemmed |
Immunizations and risk of multiple sclerosis: Systematic review and meta-analysis |
| title_sort |
immunizations and risk of multiple sclerosis: systematic review and meta-analysis |
| publishDate |
2011 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03405354_v258_n7_p1197_Farez http://hdl.handle.net/20.500.12110/paper_03405354_v258_n7_p1197_Farez |
| _version_ |
1768545418717691904 |