Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model

Implantation is one of the most regulated processes in human reproduction, by endocrine and immunological systems. Cytokines are involved in embryo-maternal communication and an impaired balance could result in pregnancy loss. Here we investigated the effect of interleukin 1-β on the activity of two...

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Autores principales:	Fontana, Vanina Andrea, Cebral, Elisa, Calvo, Juan Carlos
Publicado:	2010
Materias:	Cytokines Embryo implantation Extracellular matrix Placenta gelatinase A gelatinase B interleukin 1beta leptin MMP2 protein, human article cell invasion controlled study cytotrophoblast enzyme activity extracellular matrix hormone release human human cell regulatory mechanism biological model cell line drug effect enzymology female metabolism nidation physiology pregnancy secretion trophoblast Cell Line Embryo Implantation Female Humans Interleukin-1beta Leptin Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Models, Biological Pregnancy Trophoblasts
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03279545_v34_n1_p37_Fontana http://hdl.handle.net/20.500.12110/paper_03279545_v34_n1_p37_Fontana
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03279545_v34_n1_p37_Fontana
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spelling	paper:paper_03279545_v34_n1_p37_Fontana2023-06-08T15:33:45Z Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model Fontana, Vanina Andrea Cebral, Elisa Calvo, Juan Carlos Cytokines Embryo implantation Extracellular matrix Placenta gelatinase A gelatinase B interleukin 1beta leptin gelatinase A gelatinase B interleukin 1beta leptin MMP2 protein, human article cell invasion controlled study cytotrophoblast enzyme activity extracellular matrix hormone release human human cell regulatory mechanism biological model cell line drug effect enzymology female metabolism nidation physiology pregnancy secretion trophoblast Cell Line Embryo Implantation Female Humans Interleukin-1beta Leptin Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Models, Biological Pregnancy Trophoblasts Implantation is one of the most regulated processes in human reproduction, by endocrine and immunological systems. Cytokines are involved in embryo-maternal communication and an impaired balance could result in pregnancy loss. Here we investigated the effect of interleukin 1-β on the activity of two important metalloproteinases (MMP-2 and MMP-9) that are involved in extracellular matrix remodeling as well as the secretion of leptin, one of the reproductive hormones actively regulating their activity and secretion. We found that IL-1β activates matrix metalloproteinase activity as well as increases leptin secretion. We propose that this interleukin, through the regulation of leptin, in turn activates matrix metalloproteinases which results in an increased cytotrophoblast invasion. Fil:Fontana, V.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cebral, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Calvo, J.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03279545_v34_n1_p37_Fontana http://hdl.handle.net/20.500.12110/paper_03279545_v34_n1_p37_Fontana
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Cytokines Embryo implantation Extracellular matrix Placenta gelatinase A gelatinase B interleukin 1beta leptin gelatinase A gelatinase B interleukin 1beta leptin MMP2 protein, human article cell invasion controlled study cytotrophoblast enzyme activity extracellular matrix hormone release human human cell regulatory mechanism biological model cell line drug effect enzymology female metabolism nidation physiology pregnancy secretion trophoblast Cell Line Embryo Implantation Female Humans Interleukin-1beta Leptin Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Models, Biological Pregnancy Trophoblasts
spellingShingle	Cytokines Embryo implantation Extracellular matrix Placenta gelatinase A gelatinase B interleukin 1beta leptin gelatinase A gelatinase B interleukin 1beta leptin MMP2 protein, human article cell invasion controlled study cytotrophoblast enzyme activity extracellular matrix hormone release human human cell regulatory mechanism biological model cell line drug effect enzymology female metabolism nidation physiology pregnancy secretion trophoblast Cell Line Embryo Implantation Female Humans Interleukin-1beta Leptin Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Models, Biological Pregnancy Trophoblasts Fontana, Vanina Andrea Cebral, Elisa Calvo, Juan Carlos Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model
topic_facet	Cytokines Embryo implantation Extracellular matrix Placenta gelatinase A gelatinase B interleukin 1beta leptin gelatinase A gelatinase B interleukin 1beta leptin MMP2 protein, human article cell invasion controlled study cytotrophoblast enzyme activity extracellular matrix hormone release human human cell regulatory mechanism biological model cell line drug effect enzymology female metabolism nidation physiology pregnancy secretion trophoblast Cell Line Embryo Implantation Female Humans Interleukin-1beta Leptin Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Models, Biological Pregnancy Trophoblasts
description	Implantation is one of the most regulated processes in human reproduction, by endocrine and immunological systems. Cytokines are involved in embryo-maternal communication and an impaired balance could result in pregnancy loss. Here we investigated the effect of interleukin 1-β on the activity of two important metalloproteinases (MMP-2 and MMP-9) that are involved in extracellular matrix remodeling as well as the secretion of leptin, one of the reproductive hormones actively regulating their activity and secretion. We found that IL-1β activates matrix metalloproteinase activity as well as increases leptin secretion. We propose that this interleukin, through the regulation of leptin, in turn activates matrix metalloproteinases which results in an increased cytotrophoblast invasion.
author	Fontana, Vanina Andrea Cebral, Elisa Calvo, Juan Carlos
author_facet	Fontana, Vanina Andrea Cebral, Elisa Calvo, Juan Carlos
author_sort	Fontana, Vanina Andrea
title	Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model
title_short	Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model
title_full	Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model
title_fullStr	Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model
title_full_unstemmed	Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model
title_sort	interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model
publishDate	2010
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03279545_v34_n1_p37_Fontana http://hdl.handle.net/20.500.12110/paper_03279545_v34_n1_p37_Fontana
work_keys_str_mv	AT fontanavaninaandrea interleukin1bregulatesmetalloproteinaseactivityandleptinsecretioninacytotrophoblastmodel AT cebralelisa interleukin1bregulatesmetalloproteinaseactivityandleptinsecretioninacytotrophoblastmodel AT calvojuancarlos interleukin1bregulatesmetalloproteinaseactivityandleptinsecretioninacytotrophoblastmodel
_version_	1768544867552591872

Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model

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