Nitric oxide and enzymes in liver transplantation: Evolutive profiles
Nitric oxide, a free radical and a potent vasodilator, also inhibits platelet adhesion and aggregation, reduces adhesion of leukocytes to the endothelium and suppresses proliferation of vascular smooth muscle cells. An inducible form of the nitric oxide synthase may generate large quantities of nitr...
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paper:paper_03252957_v36_n4_p575_Zanaro2023-06-08T15:32:16Z Nitric oxide and enzymes in liver transplantation: Evolutive profiles Sassetti, Beatriz Liver transplantation Nitric oxide Nitric oxide synthase alanine aminotransferase aspartate aminotransferase cytokine enzyme lipopolysaccharide nitric acid article cell proliferation enzyme blood level evolution human ischemia Kupffer cell liver transplantation muscle cell nonhuman protein expression sampling shock smooth muscle fiber thrombocyte vascular endothelium vasodilatation Nitric oxide, a free radical and a potent vasodilator, also inhibits platelet adhesion and aggregation, reduces adhesion of leukocytes to the endothelium and suppresses proliferation of vascular smooth muscle cells. An inducible form of the nitric oxide synthase may generate large quantities of nitric oxide, and may be induced by the action of cytokines and lipopolysaccharides. Nitric oxide can be released from the hepatic vascular endothelium, platelets and Kupffer cells as a response to ischemia-reperfusion injury and circulatory shock. Levels of nitric oxide and some enzymes obtain-ed in serum samples before liver transplantation and every 48 h till day 15 were analysed in 20 patients in order to evaluate the evolution and the possible correlation between these parameters. Following a characteristic profile, aspartate aminotransferase and alanine aminotransferase levels changed from high at the beginning, to almost normal at the end of the study while, in most cases, nitric oxide kept a high level, which could be due to ischemic episodes that contributed to the expression of inducible nitric oxide synthase, as well as its activation by cytokines. Fil:Sassetti, B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2002 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v36_n4_p575_Zanaro http://hdl.handle.net/20.500.12110/paper_03252957_v36_n4_p575_Zanaro |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Liver transplantation Nitric oxide Nitric oxide synthase alanine aminotransferase aspartate aminotransferase cytokine enzyme lipopolysaccharide nitric acid article cell proliferation enzyme blood level evolution human ischemia Kupffer cell liver transplantation muscle cell nonhuman protein expression sampling shock smooth muscle fiber thrombocyte vascular endothelium vasodilatation |
| spellingShingle |
Liver transplantation Nitric oxide Nitric oxide synthase alanine aminotransferase aspartate aminotransferase cytokine enzyme lipopolysaccharide nitric acid article cell proliferation enzyme blood level evolution human ischemia Kupffer cell liver transplantation muscle cell nonhuman protein expression sampling shock smooth muscle fiber thrombocyte vascular endothelium vasodilatation Sassetti, Beatriz Nitric oxide and enzymes in liver transplantation: Evolutive profiles |
| topic_facet |
Liver transplantation Nitric oxide Nitric oxide synthase alanine aminotransferase aspartate aminotransferase cytokine enzyme lipopolysaccharide nitric acid article cell proliferation enzyme blood level evolution human ischemia Kupffer cell liver transplantation muscle cell nonhuman protein expression sampling shock smooth muscle fiber thrombocyte vascular endothelium vasodilatation |
| description |
Nitric oxide, a free radical and a potent vasodilator, also inhibits platelet adhesion and aggregation, reduces adhesion of leukocytes to the endothelium and suppresses proliferation of vascular smooth muscle cells. An inducible form of the nitric oxide synthase may generate large quantities of nitric oxide, and may be induced by the action of cytokines and lipopolysaccharides. Nitric oxide can be released from the hepatic vascular endothelium, platelets and Kupffer cells as a response to ischemia-reperfusion injury and circulatory shock. Levels of nitric oxide and some enzymes obtain-ed in serum samples before liver transplantation and every 48 h till day 15 were analysed in 20 patients in order to evaluate the evolution and the possible correlation between these parameters. Following a characteristic profile, aspartate aminotransferase and alanine aminotransferase levels changed from high at the beginning, to almost normal at the end of the study while, in most cases, nitric oxide kept a high level, which could be due to ischemic episodes that contributed to the expression of inducible nitric oxide synthase, as well as its activation by cytokines. |
| author |
Sassetti, Beatriz |
| author_facet |
Sassetti, Beatriz |
| author_sort |
Sassetti, Beatriz |
| title |
Nitric oxide and enzymes in liver transplantation: Evolutive profiles |
| title_short |
Nitric oxide and enzymes in liver transplantation: Evolutive profiles |
| title_full |
Nitric oxide and enzymes in liver transplantation: Evolutive profiles |
| title_fullStr |
Nitric oxide and enzymes in liver transplantation: Evolutive profiles |
| title_full_unstemmed |
Nitric oxide and enzymes in liver transplantation: Evolutive profiles |
| title_sort |
nitric oxide and enzymes in liver transplantation: evolutive profiles |
| publishDate |
2002 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v36_n4_p575_Zanaro http://hdl.handle.net/20.500.12110/paper_03252957_v36_n4_p575_Zanaro |
| work_keys_str_mv |
AT sassettibeatriz nitricoxideandenzymesinlivertransplantationevolutiveprofiles |
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