Alteraciones en la enzimología de la productión de aldosterona

The late pathway of aldosterone production (conversion of 11-deoxycorticosterone into aldosterone) in mitochondria of rat adrenal zona glomerulosa is catalyzed by CYP11B2. In zona fasciculate, CYP11B1 transforms 11-deoxycorticosterone into corticosterone or 18-hydroxy-11-deoxycorticosterone. Homolog...

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Autores principales: Matkovic, Laura Beatriz, Cozza, Eduardo Néstor
Publicado: 1998
Materias:
Adrenal
Aldoaterone
Aldosteronism
Cytochrome p450
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v32_n1_p3_Matkovic
http://hdl.handle.net/20.500.12110/paper_03252957_v32_n1_p3_Matkovic
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_03252957_v32_n1_p3_Matkovic
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spelling paper:paper_03252957_v32_n1_p3_Matkovic2023-06-08T15:32:15Z Alteraciones en la enzimología de la productión de aldosterona Matkovic, Laura Beatriz Cozza, Eduardo Néstor Adrenal Aldoaterone Aldosteronism Cytochrome p450 The late pathway of aldosterone production (conversion of 11-deoxycorticosterone into aldosterone) in mitochondria of rat adrenal zona glomerulosa is catalyzed by CYP11B2. In zona fasciculate, CYP11B1 transforms 11-deoxycorticosterone into corticosterone or 18-hydroxy-11-deoxycorticosterone. Homology between CYP11B1 and CYP11B2 is very high, both genes being located in tandem in chromosome 8q22. Mutations in the CYP11B2 gene and genetic recombination between CYP11B1 and CYP11B2 could be responsible for alterations in the enzymology of aldosterone production, raising a new nomenclature and explanations for the deficiencies primarily described, as CMOI and CMOII. Fil:Matkovic, L.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cozza, E.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1998 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v32_n1_p3_Matkovic http://hdl.handle.net/20.500.12110/paper_03252957_v32_n1_p3_Matkovic
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Adrenal
Aldoaterone
Aldosteronism
Cytochrome p450
spellingShingle Adrenal
Aldoaterone
Aldosteronism
Cytochrome p450
Matkovic, Laura Beatriz
Cozza, Eduardo Néstor
Alteraciones en la enzimología de la productión de aldosterona
topic_facet Adrenal
Aldoaterone
Aldosteronism
Cytochrome p450
description The late pathway of aldosterone production (conversion of 11-deoxycorticosterone into aldosterone) in mitochondria of rat adrenal zona glomerulosa is catalyzed by CYP11B2. In zona fasciculate, CYP11B1 transforms 11-deoxycorticosterone into corticosterone or 18-hydroxy-11-deoxycorticosterone. Homology between CYP11B1 and CYP11B2 is very high, both genes being located in tandem in chromosome 8q22. Mutations in the CYP11B2 gene and genetic recombination between CYP11B1 and CYP11B2 could be responsible for alterations in the enzymology of aldosterone production, raising a new nomenclature and explanations for the deficiencies primarily described, as CMOI and CMOII.
author Matkovic, Laura Beatriz
Cozza, Eduardo Néstor
author_facet Matkovic, Laura Beatriz
Cozza, Eduardo Néstor
author_sort Matkovic, Laura Beatriz
title Alteraciones en la enzimología de la productión de aldosterona
title_short Alteraciones en la enzimología de la productión de aldosterona
title_full Alteraciones en la enzimología de la productión de aldosterona
title_fullStr Alteraciones en la enzimología de la productión de aldosterona
title_full_unstemmed Alteraciones en la enzimología de la productión de aldosterona
title_sort alteraciones en la enzimología de la productión de aldosterona
publishDate 1998
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v32_n1_p3_Matkovic
http://hdl.handle.net/20.500.12110/paper_03252957_v32_n1_p3_Matkovic
work_keys_str_mv AT matkoviclaurabeatriz alteracionesenlaenzimologiadelaproductiondealdosterona
AT cozzaeduardonestor alteracionesenlaenzimologiadelaproductiondealdosterona
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