Cutaneous signs as parameter in teratogenicity by heavy metal intoxication

Teratogenic effects of heavy metals (Cd2+- and Pb 2+-acetates and Cu2+-sulphate) were studied on chick embryos, after the administration as a single dose. Test materials were injected into the yolk on day 12 of incubation. Tested concentrations were (nmole/g egg): Cd2+ Dose 1(D1): 0.16 and Dose 2 (D...

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Detalles Bibliográficos
Autores principales: Pauza, Noemí Laura, Ferramola, Ana María, Sancovich, Horacio Alberto
Publicado: 2007
Materias:
Chick embryos
Heavy metals
Teratogenic effects
Toxic effects
Yolk sac membrane
cadmium acetate
copper sulfate
lead acetate
animal experiment
animal model
article
body mass
chick embryo
controlled study
embryo
embryo mortality
heavy metal poisoning
liver hemorrhage
nonhuman
skin bleeding
skin manifestation
teratogenicity
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252787_v88_n1_p28_Pauza
http://hdl.handle.net/20.500.12110/paper_03252787_v88_n1_p28_Pauza
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_03252787_v88_n1_p28_Pauza
record_format dspace
spelling paper:paper_03252787_v88_n1_p28_Pauza2023-06-08T15:32:10Z Cutaneous signs as parameter in teratogenicity by heavy metal intoxication Pauza, Noemí Laura Ferramola, Ana María Sancovich, Horacio Alberto Chick embryos Heavy metals Teratogenic effects Toxic effects Yolk sac membrane cadmium acetate copper sulfate lead acetate animal experiment animal model article body mass chick embryo controlled study embryo embryo mortality heavy metal poisoning liver hemorrhage nonhuman skin bleeding skin manifestation teratogenicity Teratogenic effects of heavy metals (Cd2+- and Pb 2+-acetates and Cu2+-sulphate) were studied on chick embryos, after the administration as a single dose. Test materials were injected into the yolk on day 12 of incubation. Tested concentrations were (nmole/g egg): Cd2+ Dose 1(D1): 0.16 and Dose 2 (D2): 0.32; Pb2+: D1: 8.0 and D2: 16.0 and Cu2+: D1: 1.7 and D2: 3.3. Evaluations were performed after in ovo incubation for 12 and 60 hours. Embryonic mortality did not increase at the two dose levels of Cu2+ and Pb2+, while Cd2+ caused 30 and 86% of mortality, showing dose and time responses. Eggs treated with D2 of Cd2+ for 60 hs, significantly decreased the average of body mass embryo, when compared to the control group. Cd2+ administration was resposible for the most severe teratogenic signs compared to Cu2+ and Pb2+ treatments. It can be concluded that heavy metals are embryotoxic and teratogenics. We suggest that cutaneous and liver hemorrhages are the best signs to evaluate teratogenicity induced by Cd2+, Cu2+ and Pb2+. Fil:Pauza, N.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ferramola De Sancovich, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sancovich, H.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252787_v88_n1_p28_Pauza http://hdl.handle.net/20.500.12110/paper_03252787_v88_n1_p28_Pauza
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Chick embryos
Heavy metals
Teratogenic effects
Toxic effects
Yolk sac membrane
cadmium acetate
copper sulfate
lead acetate
animal experiment
animal model
article
body mass
chick embryo
controlled study
embryo
embryo mortality
heavy metal poisoning
liver hemorrhage
nonhuman
skin bleeding
skin manifestation
teratogenicity
spellingShingle Chick embryos
Heavy metals
Teratogenic effects
Toxic effects
Yolk sac membrane
cadmium acetate
copper sulfate
lead acetate
animal experiment
animal model
article
body mass
chick embryo
controlled study
embryo
embryo mortality
heavy metal poisoning
liver hemorrhage
nonhuman
skin bleeding
skin manifestation
teratogenicity
Pauza, Noemí Laura
Ferramola, Ana María
Sancovich, Horacio Alberto
Cutaneous signs as parameter in teratogenicity by heavy metal intoxication
topic_facet Chick embryos
Heavy metals
Teratogenic effects
Toxic effects
Yolk sac membrane
cadmium acetate
copper sulfate
lead acetate
animal experiment
animal model
article
body mass
chick embryo
controlled study
embryo
embryo mortality
heavy metal poisoning
liver hemorrhage
nonhuman
skin bleeding
skin manifestation
teratogenicity
description Teratogenic effects of heavy metals (Cd2+- and Pb 2+-acetates and Cu2+-sulphate) were studied on chick embryos, after the administration as a single dose. Test materials were injected into the yolk on day 12 of incubation. Tested concentrations were (nmole/g egg): Cd2+ Dose 1(D1): 0.16 and Dose 2 (D2): 0.32; Pb2+: D1: 8.0 and D2: 16.0 and Cu2+: D1: 1.7 and D2: 3.3. Evaluations were performed after in ovo incubation for 12 and 60 hours. Embryonic mortality did not increase at the two dose levels of Cu2+ and Pb2+, while Cd2+ caused 30 and 86% of mortality, showing dose and time responses. Eggs treated with D2 of Cd2+ for 60 hs, significantly decreased the average of body mass embryo, when compared to the control group. Cd2+ administration was resposible for the most severe teratogenic signs compared to Cu2+ and Pb2+ treatments. It can be concluded that heavy metals are embryotoxic and teratogenics. We suggest that cutaneous and liver hemorrhages are the best signs to evaluate teratogenicity induced by Cd2+, Cu2+ and Pb2+.
author Pauza, Noemí Laura
Ferramola, Ana María
Sancovich, Horacio Alberto
author_facet Pauza, Noemí Laura
Ferramola, Ana María
Sancovich, Horacio Alberto
author_sort Pauza, Noemí Laura
title Cutaneous signs as parameter in teratogenicity by heavy metal intoxication
title_short Cutaneous signs as parameter in teratogenicity by heavy metal intoxication
title_full Cutaneous signs as parameter in teratogenicity by heavy metal intoxication
title_fullStr Cutaneous signs as parameter in teratogenicity by heavy metal intoxication
title_full_unstemmed Cutaneous signs as parameter in teratogenicity by heavy metal intoxication
title_sort cutaneous signs as parameter in teratogenicity by heavy metal intoxication
publishDate 2007
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252787_v88_n1_p28_Pauza
http://hdl.handle.net/20.500.12110/paper_03252787_v88_n1_p28_Pauza
work_keys_str_mv AT pauzanoemilaura cutaneoussignsasparameterinteratogenicitybyheavymetalintoxication
AT ferramolaanamaria cutaneoussignsasparameterinteratogenicitybyheavymetalintoxication
AT sancovichhoracioalberto cutaneoussignsasparameterinteratogenicitybyheavymetalintoxication
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