Effect of chronic administration of verapamil in Duchenne muscular dystrophy
1. 1. In DMD patients the effect of chronic treatment with verapamil was investigated in the p-nitrophenylphosphatase from erythrocytes, the CK and LDH in serum and the functional activity of the muscle. 2. 2. A different behaviour in the p-nitrophenylphosphatase from untreated compared to treated D...
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1990
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v21_n6_p939_Garcia http://hdl.handle.net/20.500.12110/paper_03063623_v21_n6_p939_Garcia |
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paper:paper_03063623_v21_n6_p939_Garcia2023-06-08T15:31:05Z Effect of chronic administration of verapamil in Duchenne muscular dystrophy 4 nitrophenylphosphatase erythrocyte enzyme verapamil article child clinical article controlled study creatine kinase blood level duchenne muscular dystrophy human lactate dehydrogenase blood level male oral drug administration priority journal 4-Nitrophenylphosphatase Adolescent Alkaline Phosphatase Child Child, Preschool Comparative Study Creatine Kinase Erythrocytes Human Lactate Dehydrogenase Male Muscles Muscular Dystrophies Support, Non-U.S. Gov't Time Factors Verapamil 1. 1. In DMD patients the effect of chronic treatment with verapamil was investigated in the p-nitrophenylphosphatase from erythrocytes, the CK and LDH in serum and the functional activity of the muscle. 2. 2. A different behaviour in the p-nitrophenylphosphatase from untreated compared to treated DMD patients and controls is supported by the following findings: (a) values of "n" altered in F- inhibition of the enzyme with Hill coefficients -1.43, -2.18 and -2.19; (b) Arrhenius plots between 16 and 40°C with inflection points for the enzyme from treated DMD patients and controls and not from untreated DMD patients. 3. 3. Although CK and LDH in serum and the muscular evaluation showed no statistical difference between both groups, evidence is presented that in treated DMD patients the interaction membrane-enzyme is different from untreated DMD patients. © 1990. 1990 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v21_n6_p939_Garcia http://hdl.handle.net/20.500.12110/paper_03063623_v21_n6_p939_Garcia |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
4 nitrophenylphosphatase erythrocyte enzyme verapamil article child clinical article controlled study creatine kinase blood level duchenne muscular dystrophy human lactate dehydrogenase blood level male oral drug administration priority journal 4-Nitrophenylphosphatase Adolescent Alkaline Phosphatase Child Child, Preschool Comparative Study Creatine Kinase Erythrocytes Human Lactate Dehydrogenase Male Muscles Muscular Dystrophies Support, Non-U.S. Gov't Time Factors Verapamil |
| spellingShingle |
4 nitrophenylphosphatase erythrocyte enzyme verapamil article child clinical article controlled study creatine kinase blood level duchenne muscular dystrophy human lactate dehydrogenase blood level male oral drug administration priority journal 4-Nitrophenylphosphatase Adolescent Alkaline Phosphatase Child Child, Preschool Comparative Study Creatine Kinase Erythrocytes Human Lactate Dehydrogenase Male Muscles Muscular Dystrophies Support, Non-U.S. Gov't Time Factors Verapamil Effect of chronic administration of verapamil in Duchenne muscular dystrophy |
| topic_facet |
4 nitrophenylphosphatase erythrocyte enzyme verapamil article child clinical article controlled study creatine kinase blood level duchenne muscular dystrophy human lactate dehydrogenase blood level male oral drug administration priority journal 4-Nitrophenylphosphatase Adolescent Alkaline Phosphatase Child Child, Preschool Comparative Study Creatine Kinase Erythrocytes Human Lactate Dehydrogenase Male Muscles Muscular Dystrophies Support, Non-U.S. Gov't Time Factors Verapamil |
| description |
1. 1. In DMD patients the effect of chronic treatment with verapamil was investigated in the p-nitrophenylphosphatase from erythrocytes, the CK and LDH in serum and the functional activity of the muscle. 2. 2. A different behaviour in the p-nitrophenylphosphatase from untreated compared to treated DMD patients and controls is supported by the following findings: (a) values of "n" altered in F- inhibition of the enzyme with Hill coefficients -1.43, -2.18 and -2.19; (b) Arrhenius plots between 16 and 40°C with inflection points for the enzyme from treated DMD patients and controls and not from untreated DMD patients. 3. 3. Although CK and LDH in serum and the muscular evaluation showed no statistical difference between both groups, evidence is presented that in treated DMD patients the interaction membrane-enzyme is different from untreated DMD patients. © 1990. |
| title |
Effect of chronic administration of verapamil in Duchenne muscular dystrophy |
| title_short |
Effect of chronic administration of verapamil in Duchenne muscular dystrophy |
| title_full |
Effect of chronic administration of verapamil in Duchenne muscular dystrophy |
| title_fullStr |
Effect of chronic administration of verapamil in Duchenne muscular dystrophy |
| title_full_unstemmed |
Effect of chronic administration of verapamil in Duchenne muscular dystrophy |
| title_sort |
effect of chronic administration of verapamil in duchenne muscular dystrophy |
| publishDate |
1990 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v21_n6_p939_Garcia http://hdl.handle.net/20.500.12110/paper_03063623_v21_n6_p939_Garcia |
| _version_ |
1768541753021825024 |