Brain monoamine content in rats treated with the antidepressants mianserin and amoxapine
In male Wistar rats intraperitoneal injection (21 days) of mianserin, a tetracyclic antidepressant (10 mg/kg), produced significant dimunition (p < 0.01) of brain noradrenaline content without any changes in dopamine or serotonin content. Amoxapine, a tricyclic antidepressant with a potent inhibi...
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1983
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03056651_v11_n9_p838_Cicardo http://hdl.handle.net/20.500.12110/paper_03056651_v11_n9_p838_Cicardo |
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paper:paper_03056651_v11_n9_p838_Cicardo2023-06-08T15:30:47Z Brain monoamine content in rats treated with the antidepressants mianserin and amoxapine amoxapine brain monoamine dopamine mianserin noradrenalin serotonin animal experiment autonomic nervous system biological model central nervous system drug comparison drug efficacy intraperitoneal drug administration methodology nonhuman rat Animalia Rattus norvegicus In male Wistar rats intraperitoneal injection (21 days) of mianserin, a tetracyclic antidepressant (10 mg/kg), produced significant dimunition (p < 0.01) of brain noradrenaline content without any changes in dopamine or serotonin content. Amoxapine, a tricyclic antidepressant with a potent inhibitory action of catecholamine presynaptic uptake (10 mg/kg i.p.), did not produce any changes in brain monoamine content. During the experiments the rats treated with mianserin were more quiet than the controls and remained crowded together. 1983 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03056651_v11_n9_p838_Cicardo http://hdl.handle.net/20.500.12110/paper_03056651_v11_n9_p838_Cicardo |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
amoxapine brain monoamine dopamine mianserin noradrenalin serotonin animal experiment autonomic nervous system biological model central nervous system drug comparison drug efficacy intraperitoneal drug administration methodology nonhuman rat Animalia Rattus norvegicus |
| spellingShingle |
amoxapine brain monoamine dopamine mianserin noradrenalin serotonin animal experiment autonomic nervous system biological model central nervous system drug comparison drug efficacy intraperitoneal drug administration methodology nonhuman rat Animalia Rattus norvegicus Brain monoamine content in rats treated with the antidepressants mianserin and amoxapine |
| topic_facet |
amoxapine brain monoamine dopamine mianserin noradrenalin serotonin animal experiment autonomic nervous system biological model central nervous system drug comparison drug efficacy intraperitoneal drug administration methodology nonhuman rat Animalia Rattus norvegicus |
| description |
In male Wistar rats intraperitoneal injection (21 days) of mianserin, a tetracyclic antidepressant (10 mg/kg), produced significant dimunition (p < 0.01) of brain noradrenaline content without any changes in dopamine or serotonin content. Amoxapine, a tricyclic antidepressant with a potent inhibitory action of catecholamine presynaptic uptake (10 mg/kg i.p.), did not produce any changes in brain monoamine content. During the experiments the rats treated with mianserin were more quiet than the controls and remained crowded together. |
| title |
Brain monoamine content in rats treated with the antidepressants mianserin and amoxapine |
| title_short |
Brain monoamine content in rats treated with the antidepressants mianserin and amoxapine |
| title_full |
Brain monoamine content in rats treated with the antidepressants mianserin and amoxapine |
| title_fullStr |
Brain monoamine content in rats treated with the antidepressants mianserin and amoxapine |
| title_full_unstemmed |
Brain monoamine content in rats treated with the antidepressants mianserin and amoxapine |
| title_sort |
brain monoamine content in rats treated with the antidepressants mianserin and amoxapine |
| publishDate |
1983 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03056651_v11_n9_p838_Cicardo http://hdl.handle.net/20.500.12110/paper_03056651_v11_n9_p838_Cicardo |
| _version_ |
1768542887060963328 |