Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles
The effect of pineal indoles on fast axoplasmic transport of proteins in the sciatic nerve was examined in rats injected with [3H]leucine in the sixth lumbar dorsal root ganglion. Melatonin (350-1100 nmol) applied locally in the sciatic nerve impaired significantly axonal transport. At a 350-nmol do...
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1979
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043940_v13_n1_p29_Prevedello http://hdl.handle.net/20.500.12110/paper_03043940_v13_n1_p29_Prevedello |
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paper:paper_03043940_v13_n1_p29_Prevedello2023-06-08T15:29:28Z Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles 5 hydroxyindoleacetic acid 5 methoxyindoleacetic acid 5 methoxytryptamine indole melatonin n acetylserotonin radioisotope serotonin tryptamine vinblastine 5 methylindoleacetic acid animal experiment axoplasm flow in vitro study leucine h 3 nervous system peripheral nervous system rat sciatic nerve 5-Methoxytryptamine Animal Axonal Transport Comparative Study Hydroxyindoleacetic Acid Indoleacetic Acids Indoles Male Melatonin Nerve Tissue Proteins Pentoxifylline Peripheral Nerves Pineal Gland Rats Serotonin The effect of pineal indoles on fast axoplasmic transport of proteins in the sciatic nerve was examined in rats injected with [3H]leucine in the sixth lumbar dorsal root ganglion. Melatonin (350-1100 nmol) applied locally in the sciatic nerve impaired significantly axonal transport. At a 350-nmol dose all other indoles tested (i.e., 5-hydroxyindoleacetic acid, 5-methoxyindoleacetic acid, serotonin, N-acetylserotonin, tryptamine, 5-methoxytryptamine) were less potent than melatonin to impair fast axonal flow. Vinblastine injected either into the ganglion or in the sciatic nerve markedly inhibited axonal transport. © 1979. 1979 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043940_v13_n1_p29_Prevedello http://hdl.handle.net/20.500.12110/paper_03043940_v13_n1_p29_Prevedello |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
5 hydroxyindoleacetic acid 5 methoxyindoleacetic acid 5 methoxytryptamine indole melatonin n acetylserotonin radioisotope serotonin tryptamine vinblastine 5 methylindoleacetic acid animal experiment axoplasm flow in vitro study leucine h 3 nervous system peripheral nervous system rat sciatic nerve 5-Methoxytryptamine Animal Axonal Transport Comparative Study Hydroxyindoleacetic Acid Indoleacetic Acids Indoles Male Melatonin Nerve Tissue Proteins Pentoxifylline Peripheral Nerves Pineal Gland Rats Serotonin |
spellingShingle |
5 hydroxyindoleacetic acid 5 methoxyindoleacetic acid 5 methoxytryptamine indole melatonin n acetylserotonin radioisotope serotonin tryptamine vinblastine 5 methylindoleacetic acid animal experiment axoplasm flow in vitro study leucine h 3 nervous system peripheral nervous system rat sciatic nerve 5-Methoxytryptamine Animal Axonal Transport Comparative Study Hydroxyindoleacetic Acid Indoleacetic Acids Indoles Male Melatonin Nerve Tissue Proteins Pentoxifylline Peripheral Nerves Pineal Gland Rats Serotonin Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles |
topic_facet |
5 hydroxyindoleacetic acid 5 methoxyindoleacetic acid 5 methoxytryptamine indole melatonin n acetylserotonin radioisotope serotonin tryptamine vinblastine 5 methylindoleacetic acid animal experiment axoplasm flow in vitro study leucine h 3 nervous system peripheral nervous system rat sciatic nerve 5-Methoxytryptamine Animal Axonal Transport Comparative Study Hydroxyindoleacetic Acid Indoleacetic Acids Indoles Male Melatonin Nerve Tissue Proteins Pentoxifylline Peripheral Nerves Pineal Gland Rats Serotonin |
description |
The effect of pineal indoles on fast axoplasmic transport of proteins in the sciatic nerve was examined in rats injected with [3H]leucine in the sixth lumbar dorsal root ganglion. Melatonin (350-1100 nmol) applied locally in the sciatic nerve impaired significantly axonal transport. At a 350-nmol dose all other indoles tested (i.e., 5-hydroxyindoleacetic acid, 5-methoxyindoleacetic acid, serotonin, N-acetylserotonin, tryptamine, 5-methoxytryptamine) were less potent than melatonin to impair fast axonal flow. Vinblastine injected either into the ganglion or in the sciatic nerve markedly inhibited axonal transport. © 1979. |
title |
Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles |
title_short |
Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles |
title_full |
Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles |
title_fullStr |
Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles |
title_full_unstemmed |
Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles |
title_sort |
fast axonal transport in rat sciatic nerve. inhibition by pineal indoles |
publishDate |
1979 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043940_v13_n1_p29_Prevedello http://hdl.handle.net/20.500.12110/paper_03043940_v13_n1_p29_Prevedello |
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1768542939030487040 |