Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome
Alterations in ovarian angiogenesis are common features in Polycystic Ovary Syndrome (PCOS) patients; the most studied of these alterations is the increase in vascular endothelial growth factor (VEGF) production by ovarian cells. Platelet-derived growth factor B (PDGFB) and D (PDGFD) are decreased i...
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v433_n_p47_DiPietro http://hdl.handle.net/20.500.12110/paper_03037207_v433_n_p47_DiPietro |
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paper:paper_03037207_v433_n_p47_DiPietro2023-06-08T15:29:12Z Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome di Pietro, María Florencia Irusta, Griselda Tesone, Marta Parborell, M.Fernanda A. Abramovich, Dalhia Nurit Angiogenesis Ovary Platelet derived growth factor Polycystic ovary syndrome Muellerian inhibiting factor prasterone recombinant platelet derived growth factor recombinant platelet derived growth factor B unclassified drug vasculotropin Muellerian inhibiting factor platelet derived growth factor B vasculotropin A animal cell animal experiment animal model animal tissue Article controlled study corpus luteum drug efficacy drug mechanism endothelium cell female hormone synthesis nonhuman ovary cyst ovary development ovary follicle development ovary polycystic disease ovulation periendothelium cell priority journal rat animal drug effects metabolism Neovascularization, Pathologic Ovarian Hyperstimulation Syndrome ovary follicle ovary follicle fluid ovulation Polycystic Ovary Syndrome Sprague Dawley rat Animals Anti-Mullerian Hormone Female Follicular Fluid Neovascularization, Pathologic Ovarian Follicle Ovarian Hyperstimulation Syndrome Ovulation Polycystic Ovary Syndrome Proto-Oncogene Proteins c-sis Rats Rats, Sprague-Dawley Vascular Endothelial Growth Factor A Alterations in ovarian angiogenesis are common features in Polycystic Ovary Syndrome (PCOS) patients; the most studied of these alterations is the increase in vascular endothelial growth factor (VEGF) production by ovarian cells. Platelet-derived growth factor B (PDGFB) and D (PDGFD) are decreased in follicular fluid of PCOS patients and in the ovaries of a rat model of PCOS. In the present study, we aimed to analyze the effects of local administration of PDGFB on ovarian angiogenesis, follicular development and ovulation in a DHEA-induced PCOS rat model. Ovarian PDGFB administration to PCOS rats partially restored follicular development, decreased the percentage of cysts, increased the percentage of corpora lutea, and decreased the production of anti-Müllerian hormone. In addition, PDGFB administration improved ovarian angiogenesis by reversing the increase in periendothelial cell area and restoring VEGF levels. Our results shed light into the mechanisms that lead to altered ovarian function in PCOS and provide new data for potential therapeutic strategies. © 2016 Elsevier Ireland Ltd. Fil:Di Pietro, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Irusta, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Tesone, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Parborell, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Abramovich, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v433_n_p47_DiPietro http://hdl.handle.net/20.500.12110/paper_03037207_v433_n_p47_DiPietro |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Angiogenesis Ovary Platelet derived growth factor Polycystic ovary syndrome Muellerian inhibiting factor prasterone recombinant platelet derived growth factor recombinant platelet derived growth factor B unclassified drug vasculotropin Muellerian inhibiting factor platelet derived growth factor B vasculotropin A animal cell animal experiment animal model animal tissue Article controlled study corpus luteum drug efficacy drug mechanism endothelium cell female hormone synthesis nonhuman ovary cyst ovary development ovary follicle development ovary polycystic disease ovulation periendothelium cell priority journal rat animal drug effects metabolism Neovascularization, Pathologic Ovarian Hyperstimulation Syndrome ovary follicle ovary follicle fluid ovulation Polycystic Ovary Syndrome Sprague Dawley rat Animals Anti-Mullerian Hormone Female Follicular Fluid Neovascularization, Pathologic Ovarian Follicle Ovarian Hyperstimulation Syndrome Ovulation Polycystic Ovary Syndrome Proto-Oncogene Proteins c-sis Rats Rats, Sprague-Dawley Vascular Endothelial Growth Factor A |
| spellingShingle |
Angiogenesis Ovary Platelet derived growth factor Polycystic ovary syndrome Muellerian inhibiting factor prasterone recombinant platelet derived growth factor recombinant platelet derived growth factor B unclassified drug vasculotropin Muellerian inhibiting factor platelet derived growth factor B vasculotropin A animal cell animal experiment animal model animal tissue Article controlled study corpus luteum drug efficacy drug mechanism endothelium cell female hormone synthesis nonhuman ovary cyst ovary development ovary follicle development ovary polycystic disease ovulation periendothelium cell priority journal rat animal drug effects metabolism Neovascularization, Pathologic Ovarian Hyperstimulation Syndrome ovary follicle ovary follicle fluid ovulation Polycystic Ovary Syndrome Sprague Dawley rat Animals Anti-Mullerian Hormone Female Follicular Fluid Neovascularization, Pathologic Ovarian Follicle Ovarian Hyperstimulation Syndrome Ovulation Polycystic Ovary Syndrome Proto-Oncogene Proteins c-sis Rats Rats, Sprague-Dawley Vascular Endothelial Growth Factor A di Pietro, María Florencia Irusta, Griselda Tesone, Marta Parborell, M.Fernanda A. Abramovich, Dalhia Nurit Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome |
| topic_facet |
Angiogenesis Ovary Platelet derived growth factor Polycystic ovary syndrome Muellerian inhibiting factor prasterone recombinant platelet derived growth factor recombinant platelet derived growth factor B unclassified drug vasculotropin Muellerian inhibiting factor platelet derived growth factor B vasculotropin A animal cell animal experiment animal model animal tissue Article controlled study corpus luteum drug efficacy drug mechanism endothelium cell female hormone synthesis nonhuman ovary cyst ovary development ovary follicle development ovary polycystic disease ovulation periendothelium cell priority journal rat animal drug effects metabolism Neovascularization, Pathologic Ovarian Hyperstimulation Syndrome ovary follicle ovary follicle fluid ovulation Polycystic Ovary Syndrome Sprague Dawley rat Animals Anti-Mullerian Hormone Female Follicular Fluid Neovascularization, Pathologic Ovarian Follicle Ovarian Hyperstimulation Syndrome Ovulation Polycystic Ovary Syndrome Proto-Oncogene Proteins c-sis Rats Rats, Sprague-Dawley Vascular Endothelial Growth Factor A |
| description |
Alterations in ovarian angiogenesis are common features in Polycystic Ovary Syndrome (PCOS) patients; the most studied of these alterations is the increase in vascular endothelial growth factor (VEGF) production by ovarian cells. Platelet-derived growth factor B (PDGFB) and D (PDGFD) are decreased in follicular fluid of PCOS patients and in the ovaries of a rat model of PCOS. In the present study, we aimed to analyze the effects of local administration of PDGFB on ovarian angiogenesis, follicular development and ovulation in a DHEA-induced PCOS rat model. Ovarian PDGFB administration to PCOS rats partially restored follicular development, decreased the percentage of cysts, increased the percentage of corpora lutea, and decreased the production of anti-Müllerian hormone. In addition, PDGFB administration improved ovarian angiogenesis by reversing the increase in periendothelial cell area and restoring VEGF levels. Our results shed light into the mechanisms that lead to altered ovarian function in PCOS and provide new data for potential therapeutic strategies. © 2016 Elsevier Ireland Ltd. |
| author |
di Pietro, María Florencia Irusta, Griselda Tesone, Marta Parborell, M.Fernanda A. Abramovich, Dalhia Nurit |
| author_facet |
di Pietro, María Florencia Irusta, Griselda Tesone, Marta Parborell, M.Fernanda A. Abramovich, Dalhia Nurit |
| author_sort |
di Pietro, María Florencia |
| title |
Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome |
| title_short |
Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome |
| title_full |
Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome |
| title_fullStr |
Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome |
| title_full_unstemmed |
Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome |
| title_sort |
local administration of platelet-derived growth factor b (pdgfb) improves follicular development and ovarian angiogenesis in a rat model of polycystic ovary syndrome |
| publishDate |
2016 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v433_n_p47_DiPietro http://hdl.handle.net/20.500.12110/paper_03037207_v433_n_p47_DiPietro |
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