Bone morphogenetic protein-4 control of pituitary pathophysiology

Bone morphogenetic protein-4 (BMP-4), a member of the transforming growth factor-β (TGF-β) family, is overexpressed in different prolactinoma models and induces the development of these lineage adenomas. SMAD proteins activated by growth factors of the TGF-β and BMP family interact with estrogen rec...

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Autores principales:	Giacomini, Damiana Paula, Páez Pereda, Marcelo, Gerez, Juan Atilio, Labeur, Marta Susana, Refojo, Damián
Publicado:	2006
Materias:	bone morphogenetic protein bone morphogenetic protein 4 corticotropin retinoic acid transforming growth factor beta transforming growth factor beta receptor animal biological model conference paper cytology gene expression growth, development and aging human hypophysis hypophysis disease metabolism nerve cell physiology secretion Adrenocorticotropic Hormone Animals Bone Morphogenetic Proteins Gene Expression Humans Models, Biological Neurons Pituitary Diseases Pituitary Gland Receptors, Transforming Growth Factor beta Transforming Growth Factor beta Tretinoin
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03013073_v35_n_p22_Giacomini http://hdl.handle.net/20.500.12110/paper_03013073_v35_n_p22_Giacomini
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03013073_v35_n_p22_Giacomini
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spelling	paper:paper_03013073_v35_n_p22_Giacomini2023-06-08T15:27:52Z Bone morphogenetic protein-4 control of pituitary pathophysiology Giacomini, Damiana Paula Páez Pereda, Marcelo Gerez, Juan Atilio Labeur, Marta Susana Refojo, Damián bone morphogenetic protein bone morphogenetic protein 4 corticotropin retinoic acid transforming growth factor beta transforming growth factor beta receptor animal biological model conference paper cytology gene expression growth, development and aging human hypophysis hypophysis disease metabolism nerve cell physiology secretion Adrenocorticotropic Hormone Animals Bone Morphogenetic Proteins Gene Expression Humans Models, Biological Neurons Pituitary Diseases Pituitary Gland Receptors, Transforming Growth Factor beta Transforming Growth Factor beta Tretinoin Bone morphogenetic protein-4 (BMP-4), a member of the transforming growth factor-β (TGF-β) family, is overexpressed in different prolactinoma models and induces the development of these lineage adenomas. SMAD proteins activated by growth factors of the TGF-β and BMP family interact with estrogen receptors to stimulate the proliferation of prolactin and growth hormone-secreting cells. Furthermore, BMP-4 presents differential expression in normal and adenomatous corticotropes and inhibitory action on corticotropinoma cell proliferation. Moreover, BMP-4 mediates the antiproliferative action of retinoic acid in these cells. The present review highlights not only the crucial and opposite role of BMP-4 in the progression of pituitary adenomas but also that BMP-4 and retinoic acid interaction might serve as a potential new mechanism target for therapeutic approaches for Cushing disease. Copyright © 2006 S. Karger AG. Fil:Giacomini, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Páez-Pereda, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gerez, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Labeur, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Refojo, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2006 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03013073_v35_n_p22_Giacomini http://hdl.handle.net/20.500.12110/paper_03013073_v35_n_p22_Giacomini
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	bone morphogenetic protein bone morphogenetic protein 4 corticotropin retinoic acid transforming growth factor beta transforming growth factor beta receptor animal biological model conference paper cytology gene expression growth, development and aging human hypophysis hypophysis disease metabolism nerve cell physiology secretion Adrenocorticotropic Hormone Animals Bone Morphogenetic Proteins Gene Expression Humans Models, Biological Neurons Pituitary Diseases Pituitary Gland Receptors, Transforming Growth Factor beta Transforming Growth Factor beta Tretinoin
spellingShingle	bone morphogenetic protein bone morphogenetic protein 4 corticotropin retinoic acid transforming growth factor beta transforming growth factor beta receptor animal biological model conference paper cytology gene expression growth, development and aging human hypophysis hypophysis disease metabolism nerve cell physiology secretion Adrenocorticotropic Hormone Animals Bone Morphogenetic Proteins Gene Expression Humans Models, Biological Neurons Pituitary Diseases Pituitary Gland Receptors, Transforming Growth Factor beta Transforming Growth Factor beta Tretinoin Giacomini, Damiana Paula Páez Pereda, Marcelo Gerez, Juan Atilio Labeur, Marta Susana Refojo, Damián Bone morphogenetic protein-4 control of pituitary pathophysiology
topic_facet	bone morphogenetic protein bone morphogenetic protein 4 corticotropin retinoic acid transforming growth factor beta transforming growth factor beta receptor animal biological model conference paper cytology gene expression growth, development and aging human hypophysis hypophysis disease metabolism nerve cell physiology secretion Adrenocorticotropic Hormone Animals Bone Morphogenetic Proteins Gene Expression Humans Models, Biological Neurons Pituitary Diseases Pituitary Gland Receptors, Transforming Growth Factor beta Transforming Growth Factor beta Tretinoin
description	Bone morphogenetic protein-4 (BMP-4), a member of the transforming growth factor-β (TGF-β) family, is overexpressed in different prolactinoma models and induces the development of these lineage adenomas. SMAD proteins activated by growth factors of the TGF-β and BMP family interact with estrogen receptors to stimulate the proliferation of prolactin and growth hormone-secreting cells. Furthermore, BMP-4 presents differential expression in normal and adenomatous corticotropes and inhibitory action on corticotropinoma cell proliferation. Moreover, BMP-4 mediates the antiproliferative action of retinoic acid in these cells. The present review highlights not only the crucial and opposite role of BMP-4 in the progression of pituitary adenomas but also that BMP-4 and retinoic acid interaction might serve as a potential new mechanism target for therapeutic approaches for Cushing disease. Copyright © 2006 S. Karger AG.
author	Giacomini, Damiana Paula Páez Pereda, Marcelo Gerez, Juan Atilio Labeur, Marta Susana Refojo, Damián
author_facet	Giacomini, Damiana Paula Páez Pereda, Marcelo Gerez, Juan Atilio Labeur, Marta Susana Refojo, Damián
author_sort	Giacomini, Damiana Paula
title	Bone morphogenetic protein-4 control of pituitary pathophysiology
title_short	Bone morphogenetic protein-4 control of pituitary pathophysiology
title_full	Bone morphogenetic protein-4 control of pituitary pathophysiology
title_fullStr	Bone morphogenetic protein-4 control of pituitary pathophysiology
title_full_unstemmed	Bone morphogenetic protein-4 control of pituitary pathophysiology
title_sort	bone morphogenetic protein-4 control of pituitary pathophysiology
publishDate	2006
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03013073_v35_n_p22_Giacomini http://hdl.handle.net/20.500.12110/paper_03013073_v35_n_p22_Giacomini
work_keys_str_mv	AT giacominidamianapaula bonemorphogeneticprotein4controlofpituitarypathophysiology AT paezperedamarcelo bonemorphogeneticprotein4controlofpituitarypathophysiology AT gerezjuanatilio bonemorphogeneticprotein4controlofpituitarypathophysiology AT labeurmartasusana bonemorphogeneticprotein4controlofpituitarypathophysiology AT refojodamian bonemorphogeneticprotein4controlofpituitarypathophysiology
_version_	1768544179644792832

Bone morphogenetic protein-4 control of pituitary pathophysiology

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