Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats
The effect of the opiate antagonist naloxone on serum prolactin after treatment with serotonin, arginine vasotocin (AVT) or melatonin was studied in prepubertal and adult unanesthetized rats. Prolactin was quantified in blood samples withdrawn through an intrajugular silastic cannula from undisturbe...
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1983
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v56_n1_p97_Somoza http://hdl.handle.net/20.500.12110/paper_03009564_v56_n1_p97_Somoza |
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paper:paper_03009564_v56_n1_p97_Somoza2023-06-08T15:27:41Z Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats naloxone Prolactin serotonin argiprestocin melatonin naloxone opiate receptor serotonin animal experiment drug efficacy endocrine system hypophysis nonhuman prolactin blood level radioimmunoassay rat Animals Female Melatonin Movement Naloxone Prolactin Rats Serotonin Vasotocin The effect of the opiate antagonist naloxone on serum prolactin after treatment with serotonin, arginine vasotocin (AVT) or melatonin was studied in prepubertal and adult unanesthetized rats. Prolactin was quantified in blood samples withdrawn through an intrajugular silastic cannula from undisturbed ovariectomized adult rats. After taking a basal sample, animals were injected through the cannula with naloxone (0.8 mg/kg) and 5 min later with serotonin creatinine sulphate (6.4 mg/kg), AVT (20 μg/kg), melatonin (4 mg/kg) or saline; new samples were taken 15 and 30 min thereafter. Injection of serotonin was followed by a 10-fold increase of prolactin levels 15 min later; this increase was drastically reduced, although not abolished, by pretreatment with naloxone. In animals injected with saline, AVT or melatonin, no significant changes in serum prolactin were observed. In a second group of experiments, 30 day-old female rats injected with serotonin creatinine sulphate (10 mg/kg, i.p.) exhibited a 6-fold increase in serum prolactin 15 min after injection; this increment was reduced but not abolished by pretreatment with naloxone (5 mg/kg, i.p.). It is postulated that the prolactin releasing effect of serotonin is mediated, at least in part, by an opioid receptor. © 1983 Springer-Verlag. 1983 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v56_n1_p97_Somoza http://hdl.handle.net/20.500.12110/paper_03009564_v56_n1_p97_Somoza |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
naloxone Prolactin serotonin argiprestocin melatonin naloxone opiate receptor serotonin animal experiment drug efficacy endocrine system hypophysis nonhuman prolactin blood level radioimmunoassay rat Animals Female Melatonin Movement Naloxone Prolactin Rats Serotonin Vasotocin |
| spellingShingle |
naloxone Prolactin serotonin argiprestocin melatonin naloxone opiate receptor serotonin animal experiment drug efficacy endocrine system hypophysis nonhuman prolactin blood level radioimmunoassay rat Animals Female Melatonin Movement Naloxone Prolactin Rats Serotonin Vasotocin Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats |
| topic_facet |
naloxone Prolactin serotonin argiprestocin melatonin naloxone opiate receptor serotonin animal experiment drug efficacy endocrine system hypophysis nonhuman prolactin blood level radioimmunoassay rat Animals Female Melatonin Movement Naloxone Prolactin Rats Serotonin Vasotocin |
| description |
The effect of the opiate antagonist naloxone on serum prolactin after treatment with serotonin, arginine vasotocin (AVT) or melatonin was studied in prepubertal and adult unanesthetized rats. Prolactin was quantified in blood samples withdrawn through an intrajugular silastic cannula from undisturbed ovariectomized adult rats. After taking a basal sample, animals were injected through the cannula with naloxone (0.8 mg/kg) and 5 min later with serotonin creatinine sulphate (6.4 mg/kg), AVT (20 μg/kg), melatonin (4 mg/kg) or saline; new samples were taken 15 and 30 min thereafter. Injection of serotonin was followed by a 10-fold increase of prolactin levels 15 min later; this increase was drastically reduced, although not abolished, by pretreatment with naloxone. In animals injected with saline, AVT or melatonin, no significant changes in serum prolactin were observed. In a second group of experiments, 30 day-old female rats injected with serotonin creatinine sulphate (10 mg/kg, i.p.) exhibited a 6-fold increase in serum prolactin 15 min after injection; this increment was reduced but not abolished by pretreatment with naloxone (5 mg/kg, i.p.). It is postulated that the prolactin releasing effect of serotonin is mediated, at least in part, by an opioid receptor. © 1983 Springer-Verlag. |
| title |
Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats |
| title_short |
Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats |
| title_full |
Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats |
| title_fullStr |
Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats |
| title_full_unstemmed |
Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats |
| title_sort |
inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats |
| publishDate |
1983 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v56_n1_p97_Somoza http://hdl.handle.net/20.500.12110/paper_03009564_v56_n1_p97_Somoza |
| _version_ |
1768541796404559872 |