Testosterone decreases β-adrenoceptor sites in rat pineal gland and brain

Testosterone administration to orchidectomized rats brought about a significant, 55% decrease of β-adrenoceptor sites in the pineal gland, assessed from the specific binding of radioactive dihydroalprenolol (DHA). The changes in density of binding sites were not accompanied by significant modificati...

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Publicado:	1982
Materias:	β-adrenoceptors FSH LH Pineal superior cervical ganglion testosterone androstanolone beta adrenergic receptor drug receptor follitropin luteinizing hormone propranolol radioisotope animal experiment brain central nervous system dihydroalprenolol h 3 endocrine system pineal body rat Animal Brain Castration Dihydroalprenolol Female Kinetics Male Pineal Gland Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, beta Support, Non-U.S. Gov't Testosterone
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v53_n1_p49_Vacas http://hdl.handle.net/20.500.12110/paper_03009564_v53_n1_p49_Vacas
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03009564_v53_n1_p49_Vacas
record_format	dspace
spelling	paper:paper_03009564_v53_n1_p49_Vacas2023-06-08T15:27:41Z Testosterone decreases β-adrenoceptor sites in rat pineal gland and brain β-adrenoceptors FSH LH Pineal superior cervical ganglion testosterone androstanolone beta adrenergic receptor drug receptor follitropin luteinizing hormone propranolol radioisotope testosterone animal experiment brain central nervous system dihydroalprenolol h 3 endocrine system pineal body rat Animal Brain Castration Dihydroalprenolol Female Kinetics Male Pineal Gland Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, beta Support, Non-U.S. Gov't Testosterone Testosterone administration to orchidectomized rats brought about a significant, 55% decrease of β-adrenoceptor sites in the pineal gland, assessed from the specific binding of radioactive dihydroalprenolol (DHA). The changes in density of binding sites were not accompanied by significant modifications of the Kd. FSH or LH treatment of acutely castrated animals did not affect pineal β-adrenoceptor binding. The depressive effects of testosterone in β-adrenergic receptors were also observed in crude membrane fractions of medial basal hypothalamus and cerebral cortex. Sympathetic denervation of the pineal gland by superior cervical ganglionectomy did not abolish the changes in pineal β-adrenoceptor density caused by testosterone. Hormone effects did not depend on a direct effect of the hormone on β-adrenoceptor sites because testosterone did not compete with [3H]-DHA for the binding sites, in vitro. These results suggest that testosterone depresses pineal β-adrenergic sites by acting mainly on post-synaptic sites. © 1982 Springer-Verlag. 1982 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v53_n1_p49_Vacas http://hdl.handle.net/20.500.12110/paper_03009564_v53_n1_p49_Vacas
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	β-adrenoceptors FSH LH Pineal superior cervical ganglion testosterone androstanolone beta adrenergic receptor drug receptor follitropin luteinizing hormone propranolol radioisotope testosterone animal experiment brain central nervous system dihydroalprenolol h 3 endocrine system pineal body rat Animal Brain Castration Dihydroalprenolol Female Kinetics Male Pineal Gland Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, beta Support, Non-U.S. Gov't Testosterone
spellingShingle	β-adrenoceptors FSH LH Pineal superior cervical ganglion testosterone androstanolone beta adrenergic receptor drug receptor follitropin luteinizing hormone propranolol radioisotope testosterone animal experiment brain central nervous system dihydroalprenolol h 3 endocrine system pineal body rat Animal Brain Castration Dihydroalprenolol Female Kinetics Male Pineal Gland Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, beta Support, Non-U.S. Gov't Testosterone Testosterone decreases β-adrenoceptor sites in rat pineal gland and brain
topic_facet	β-adrenoceptors FSH LH Pineal superior cervical ganglion testosterone androstanolone beta adrenergic receptor drug receptor follitropin luteinizing hormone propranolol radioisotope testosterone animal experiment brain central nervous system dihydroalprenolol h 3 endocrine system pineal body rat Animal Brain Castration Dihydroalprenolol Female Kinetics Male Pineal Gland Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, beta Support, Non-U.S. Gov't Testosterone
description	Testosterone administration to orchidectomized rats brought about a significant, 55% decrease of β-adrenoceptor sites in the pineal gland, assessed from the specific binding of radioactive dihydroalprenolol (DHA). The changes in density of binding sites were not accompanied by significant modifications of the Kd. FSH or LH treatment of acutely castrated animals did not affect pineal β-adrenoceptor binding. The depressive effects of testosterone in β-adrenergic receptors were also observed in crude membrane fractions of medial basal hypothalamus and cerebral cortex. Sympathetic denervation of the pineal gland by superior cervical ganglionectomy did not abolish the changes in pineal β-adrenoceptor density caused by testosterone. Hormone effects did not depend on a direct effect of the hormone on β-adrenoceptor sites because testosterone did not compete with [3H]-DHA for the binding sites, in vitro. These results suggest that testosterone depresses pineal β-adrenergic sites by acting mainly on post-synaptic sites. © 1982 Springer-Verlag.
title	Testosterone decreases β-adrenoceptor sites in rat pineal gland and brain
title_short	Testosterone decreases β-adrenoceptor sites in rat pineal gland and brain
title_full	Testosterone decreases β-adrenoceptor sites in rat pineal gland and brain
title_fullStr	Testosterone decreases β-adrenoceptor sites in rat pineal gland and brain
title_full_unstemmed	Testosterone decreases β-adrenoceptor sites in rat pineal gland and brain
title_sort	testosterone decreases β-adrenoceptor sites in rat pineal gland and brain
publishDate	1982
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v53_n1_p49_Vacas http://hdl.handle.net/20.500.12110/paper_03009564_v53_n1_p49_Vacas
_version_	1768544864839925760

Testosterone decreases β-adrenoceptor sites in rat pineal gland and brain

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