Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients

Antioxidant profiles in Parkinson's disease (PD; n = 15), dementias of Alzheimer's type (DAT; 18) and Vascular (VD; 15), and control subjects (C; 14) were studied. Cu-Zn superoxide dismutase (SOD), catalase (CAT), glutathione system (GLU) and thiobarbituric acid reactive substances (TBARS)...

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Detalles Bibliográficos
Autor principal: Marschoff, Enrique R.
Publicado: 2001
Materias:
Antioxidant system
Cu-Zn superoxide dismutase
Dementia of the Alzheimer's type
Oxygen free radicals
Parkinson's disease
Peripheral markers
Vascular dementia
antioxidant
catalase
copper zinc superoxide dismutase
glutathione
thiobarbituric acid reactive substance
Alzheimer disease
antioxidant activity
article
biochemistry
blood analysis
controlled study
disease marker
enzyme assay
erythrocyte level
human
major clinical study
multiinfarct dementia
oxidative stress
Parkinson disease
priority journal
Aged
Aged, 80 and over
Alzheimer Disease
Analysis of Variance
Antioxidants
Dementia, Vascular
Discriminant Analysis
Female
Humans
Male
Middle Aged
Oxidative Stress
Parkinson Disease
Statistics, Nonparametric
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v108_n10_p1135_Serra
http://hdl.handle.net/20.500.12110/paper_03009564_v108_n10_p1135_Serra
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Antioxidant profiles in Parkinson's disease (PD; n = 15), dementias of Alzheimer's type (DAT; 18) and Vascular (VD; 15), and control subjects (C; 14) were studied. Cu-Zn superoxide dismutase (SOD), catalase (CAT), glutathione system (GLU) and thiobarbituric acid reactive substances (TBARS) were measured in erythrocytes; antioxidant capacity (TRAP) in plasma. Biochemical variables were analyzed simultaneously using multivariate and non-parametric methods. Clinical diagnostic resulted associated with the main source of variability in antioxidant variables (Kruskal-Wallis: H = 32.58, p = 0.000001). Comparison of PD and C resulted highly significant (z = 4.47, p = 0.000047), demonstrating an association between oxidative stress and PD. SOD and TBARS were significantly higher in pathological groups against C (p = 0.0000001, p = 0.051); TRAP resulted lower (p = 0.00015). Discriminant functions constructed using biochemical variables separated pathological groups (93% success) from C, and DAT (88.9%) from VD (73.3%); but not PD from DAT or VD. Antioxidant profiles of PD patients showed characteristics overlapping with DAT (60%) and with VD (40%), suggesting biochemical similarities between them.

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