Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients

Antioxidant profiles in Parkinson's disease (PD; n = 15), dementias of Alzheimer's type (DAT; 18) and Vascular (VD; 15), and control subjects (C; 14) were studied. Cu-Zn superoxide dismutase (SOD), catalase (CAT), glutathione system (GLU) and thiobarbituric acid reactive substances (TBARS)...

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Autor principal:	Marschoff, Enrique R.
Publicado:	2001
Materias:	Antioxidant system Cu-Zn superoxide dismutase Dementia of the Alzheimer's type Oxygen free radicals Parkinson's disease Peripheral markers Vascular dementia antioxidant catalase copper zinc superoxide dismutase glutathione thiobarbituric acid reactive substance Alzheimer disease antioxidant activity article biochemistry blood analysis controlled study disease marker enzyme assay erythrocyte level human major clinical study multiinfarct dementia oxidative stress Parkinson disease priority journal Aged Aged, 80 and over Alzheimer Disease Analysis of Variance Antioxidants Dementia, Vascular Discriminant Analysis Female Humans Male Middle Aged Oxidative Stress Parkinson Disease Statistics, Nonparametric
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v108_n10_p1135_Serra http://hdl.handle.net/20.500.12110/paper_03009564_v108_n10_p1135_Serra
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03009564_v108_n10_p1135_Serra
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spelling	paper:paper_03009564_v108_n10_p1135_Serra2023-06-08T15:27:38Z Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients Marschoff, Enrique R. Antioxidant system Cu-Zn superoxide dismutase Dementia of the Alzheimer's type Oxygen free radicals Parkinson's disease Peripheral markers Vascular dementia antioxidant catalase copper zinc superoxide dismutase glutathione thiobarbituric acid reactive substance Alzheimer disease antioxidant activity article biochemistry blood analysis controlled study disease marker enzyme assay erythrocyte level human major clinical study multiinfarct dementia oxidative stress Parkinson disease priority journal Aged Aged, 80 and over Alzheimer Disease Analysis of Variance Antioxidants Dementia, Vascular Discriminant Analysis Female Humans Male Middle Aged Oxidative Stress Parkinson Disease Statistics, Nonparametric Antioxidant profiles in Parkinson's disease (PD; n = 15), dementias of Alzheimer's type (DAT; 18) and Vascular (VD; 15), and control subjects (C; 14) were studied. Cu-Zn superoxide dismutase (SOD), catalase (CAT), glutathione system (GLU) and thiobarbituric acid reactive substances (TBARS) were measured in erythrocytes; antioxidant capacity (TRAP) in plasma. Biochemical variables were analyzed simultaneously using multivariate and non-parametric methods. Clinical diagnostic resulted associated with the main source of variability in antioxidant variables (Kruskal-Wallis: H = 32.58, p = 0.000001). Comparison of PD and C resulted highly significant (z = 4.47, p = 0.000047), demonstrating an association between oxidative stress and PD. SOD and TBARS were significantly higher in pathological groups against C (p = 0.0000001, p = 0.051); TRAP resulted lower (p = 0.00015). Discriminant functions constructed using biochemical variables separated pathological groups (93% success) from C, and DAT (88.9%) from VD (73.3%); but not PD from DAT or VD. Antioxidant profiles of PD patients showed characteristics overlapping with DAT (60%) and with VD (40%), suggesting biochemical similarities between them. Fil:Marschoff, E.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2001 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v108_n10_p1135_Serra http://hdl.handle.net/20.500.12110/paper_03009564_v108_n10_p1135_Serra
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Antioxidant system Cu-Zn superoxide dismutase Dementia of the Alzheimer's type Oxygen free radicals Parkinson's disease Peripheral markers Vascular dementia antioxidant catalase copper zinc superoxide dismutase glutathione thiobarbituric acid reactive substance Alzheimer disease antioxidant activity article biochemistry blood analysis controlled study disease marker enzyme assay erythrocyte level human major clinical study multiinfarct dementia oxidative stress Parkinson disease priority journal Aged Aged, 80 and over Alzheimer Disease Analysis of Variance Antioxidants Dementia, Vascular Discriminant Analysis Female Humans Male Middle Aged Oxidative Stress Parkinson Disease Statistics, Nonparametric
spellingShingle	Antioxidant system Cu-Zn superoxide dismutase Dementia of the Alzheimer's type Oxygen free radicals Parkinson's disease Peripheral markers Vascular dementia antioxidant catalase copper zinc superoxide dismutase glutathione thiobarbituric acid reactive substance Alzheimer disease antioxidant activity article biochemistry blood analysis controlled study disease marker enzyme assay erythrocyte level human major clinical study multiinfarct dementia oxidative stress Parkinson disease priority journal Aged Aged, 80 and over Alzheimer Disease Analysis of Variance Antioxidants Dementia, Vascular Discriminant Analysis Female Humans Male Middle Aged Oxidative Stress Parkinson Disease Statistics, Nonparametric Marschoff, Enrique R. Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients
topic_facet	Antioxidant system Cu-Zn superoxide dismutase Dementia of the Alzheimer's type Oxygen free radicals Parkinson's disease Peripheral markers Vascular dementia antioxidant catalase copper zinc superoxide dismutase glutathione thiobarbituric acid reactive substance Alzheimer disease antioxidant activity article biochemistry blood analysis controlled study disease marker enzyme assay erythrocyte level human major clinical study multiinfarct dementia oxidative stress Parkinson disease priority journal Aged Aged, 80 and over Alzheimer Disease Analysis of Variance Antioxidants Dementia, Vascular Discriminant Analysis Female Humans Male Middle Aged Oxidative Stress Parkinson Disease Statistics, Nonparametric
description	Antioxidant profiles in Parkinson's disease (PD; n = 15), dementias of Alzheimer's type (DAT; 18) and Vascular (VD; 15), and control subjects (C; 14) were studied. Cu-Zn superoxide dismutase (SOD), catalase (CAT), glutathione system (GLU) and thiobarbituric acid reactive substances (TBARS) were measured in erythrocytes; antioxidant capacity (TRAP) in plasma. Biochemical variables were analyzed simultaneously using multivariate and non-parametric methods. Clinical diagnostic resulted associated with the main source of variability in antioxidant variables (Kruskal-Wallis: H = 32.58, p = 0.000001). Comparison of PD and C resulted highly significant (z = 4.47, p = 0.000047), demonstrating an association between oxidative stress and PD. SOD and TBARS were significantly higher in pathological groups against C (p = 0.0000001, p = 0.051); TRAP resulted lower (p = 0.00015). Discriminant functions constructed using biochemical variables separated pathological groups (93% success) from C, and DAT (88.9%) from VD (73.3%); but not PD from DAT or VD. Antioxidant profiles of PD patients showed characteristics overlapping with DAT (60%) and with VD (40%), suggesting biochemical similarities between them.
author	Marschoff, Enrique R.
author_facet	Marschoff, Enrique R.
author_sort	Marschoff, Enrique R.
title	Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients
title_short	Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients
title_full	Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients
title_fullStr	Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients
title_full_unstemmed	Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients
title_sort	parkinson's disease is associated with oxidative stress: comparison of peripheral antioxidant profiles in living parkinson's, alzheimer's and vascular dementia patients
publishDate	2001
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03009564_v108_n10_p1135_Serra http://hdl.handle.net/20.500.12110/paper_03009564_v108_n10_p1135_Serra
work_keys_str_mv	AT marschoffenriquer parkinsonsdiseaseisassociatedwithoxidativestresscomparisonofperipheralantioxidantprofilesinlivingparkinsonsalzheimersandvasculardementiapatients
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Parkinson's disease is associated with oxidative stress: Comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients

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