Interactions of Junin and Tacaribe viruses during mixed infections

The interaction between Junin virus (JV) and Tacaribe virus (TACV) during mixed infections of RK13 cells was examined. The effects of a prior infection with JV upon TACV replication depended on the time between the two inoculations. Simultaneous infection of RK13 cells with TACV and JV did not alter...

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Autores principales:	Damonte, Elsa Beatriz, Coto, Celia Esther
Publicado:	1985
Materias:	cell culture in vitro study Junin virus mixed virus infection nonhuman priority journal tacaribe arenavirus virus replication Arenavirus Tacaribe virus Vesicular stomatitis virus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03005526_v23_n1_p1_Damonte http://hdl.handle.net/20.500.12110/paper_03005526_v23_n1_p1_Damonte
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03005526_v23_n1_p1_Damonte
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spelling	paper:paper_03005526_v23_n1_p1_Damonte2023-06-08T15:27:20Z Interactions of Junin and Tacaribe viruses during mixed infections Damonte, Elsa Beatriz Coto, Celia Esther cell culture in vitro study Junin virus mixed virus infection nonhuman priority journal tacaribe arenavirus virus replication Arenavirus Junin virus Tacaribe virus Vesicular stomatitis virus The interaction between Junin virus (JV) and Tacaribe virus (TACV) during mixed infections of RK13 cells was examined. The effects of a prior infection with JV upon TACV replication depended on the time between the two inoculations. Simultaneous infection of RK13 cells with TACV and JV did not alter the plaquing efficiency of TACV; but if there was a 1- to 24-hour delay between JV preinfection and TACV superinfection, a variable increase of TACV replication was observed. The enhancement of TACV replication by preinfection with JV was dependent on several factors, such as the MOI of both viruses and the integrity of the JV genome. This effect was also highly specific, as the plaquing efficiencies of the arenavirus Pichinde and the unrelated vesicular stomatitis virus were not affected by preinfection with JV at any multiplicity assayed. The majority of the progeny formed in cells superinfected with TACV 1 or 24 hr after JV infection was partially neutralized by antisera to both viruses. This suggested that phenotypic mixing, with JV or TACV genomes enclosed within an envelope containing TACV and JV glycoproteins, has occurred. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Coto, C.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1985 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03005526_v23_n1_p1_Damonte http://hdl.handle.net/20.500.12110/paper_03005526_v23_n1_p1_Damonte
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	cell culture in vitro study Junin virus mixed virus infection nonhuman priority journal tacaribe arenavirus virus replication Arenavirus Junin virus Tacaribe virus Vesicular stomatitis virus
spellingShingle	cell culture in vitro study Junin virus mixed virus infection nonhuman priority journal tacaribe arenavirus virus replication Arenavirus Junin virus Tacaribe virus Vesicular stomatitis virus Damonte, Elsa Beatriz Coto, Celia Esther Interactions of Junin and Tacaribe viruses during mixed infections
topic_facet	cell culture in vitro study Junin virus mixed virus infection nonhuman priority journal tacaribe arenavirus virus replication Arenavirus Junin virus Tacaribe virus Vesicular stomatitis virus
description	The interaction between Junin virus (JV) and Tacaribe virus (TACV) during mixed infections of RK13 cells was examined. The effects of a prior infection with JV upon TACV replication depended on the time between the two inoculations. Simultaneous infection of RK13 cells with TACV and JV did not alter the plaquing efficiency of TACV; but if there was a 1- to 24-hour delay between JV preinfection and TACV superinfection, a variable increase of TACV replication was observed. The enhancement of TACV replication by preinfection with JV was dependent on several factors, such as the MOI of both viruses and the integrity of the JV genome. This effect was also highly specific, as the plaquing efficiencies of the arenavirus Pichinde and the unrelated vesicular stomatitis virus were not affected by preinfection with JV at any multiplicity assayed. The majority of the progeny formed in cells superinfected with TACV 1 or 24 hr after JV infection was partially neutralized by antisera to both viruses. This suggested that phenotypic mixing, with JV or TACV genomes enclosed within an envelope containing TACV and JV glycoproteins, has occurred.
author	Damonte, Elsa Beatriz Coto, Celia Esther
author_facet	Damonte, Elsa Beatriz Coto, Celia Esther
author_sort	Damonte, Elsa Beatriz
title	Interactions of Junin and Tacaribe viruses during mixed infections
title_short	Interactions of Junin and Tacaribe viruses during mixed infections
title_full	Interactions of Junin and Tacaribe viruses during mixed infections
title_fullStr	Interactions of Junin and Tacaribe viruses during mixed infections
title_full_unstemmed	Interactions of Junin and Tacaribe viruses during mixed infections
title_sort	interactions of junin and tacaribe viruses during mixed infections
publishDate	1985
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03005526_v23_n1_p1_Damonte http://hdl.handle.net/20.500.12110/paper_03005526_v23_n1_p1_Damonte
work_keys_str_mv	AT damonteelsabeatriz interactionsofjuninandtacaribevirusesduringmixedinfections AT cotoceliaesther interactionsofjuninandtacaribevirusesduringmixedinfections
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Interactions of Junin and Tacaribe viruses during mixed infections

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