Argentinean Andean propolis associated with the medicinal plant Larrea nitida Cav. (Zygophyllaceae). HPLC-MS and GC-MS characterization and antifungal activity
The chemical profile and botanical origin of Andean Argentinian propolis were studied by HPLC-ESI-MS/MS and GC-MS techniques as well as the antifungal activity according to CLSI protocols. Dermatophytes and yeasts tested were strongly inhibited by propolis extracts (MICs between 31.25 and 125 μg/mL)...
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02786915_v49_n9_p1970_Aguero http://hdl.handle.net/20.500.12110/paper_02786915_v49_n9_p1970_Aguero |
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paper:paper_02786915_v49_n9_p1970_Aguero2023-06-08T15:26:51Z Argentinean Andean propolis associated with the medicinal plant Larrea nitida Cav. (Zygophyllaceae). HPLC-MS and GC-MS characterization and antifungal activity Palermo, Jorge Alejandro Antifungal activity Argentinian Andean propolis GC-MS HPLC-ESI-MS/MS Lignans VOCs 3' methyl nordihydroguaiaretic acid 3,3',4' trihydroxy 4 methoxy 7,7' epoxylignan 3,4,3',4' tetrahydroxy 7,7' epoxylignan acetic acid ethyl ester dichloromethane lignan nordihydroguaiaretic acid nordihydroguaiaretic acid derivative phenol derivative plant medicinal product propolis unclassified drug volatile organic compound Argentina Arthroderma gypseum article Candida controlled study Cryptococcus dermatophyte drug concentration drug determination drug isolation drug screening drug structure fungal strain fungicidal activity high performance liquid chromatography Larrea Larrea nitida mass fragmentography minimum fungicidal concentration minimum inhibitory concentration nonhuman Trichophyton mentagrophytes Trichophyton rubrum Antifungal Agents Chromatography, High Pressure Liquid Gas Chromatography-Mass Spectrometry Larrea Magnetic Resonance Spectroscopy Mass Spectrometry Microbial Sensitivity Tests Propolis Arthroderma benhamiae Arthroderma gypseum Arthrodermataceae Larrea nitida Zygophyllaceae The chemical profile and botanical origin of Andean Argentinian propolis were studied by HPLC-ESI-MS/MS and GC-MS techniques as well as the antifungal activity according to CLSI protocols. Dermatophytes and yeasts tested were strongly inhibited by propolis extracts (MICs between 31.25 and 125 μg/mL). The main antifungal compounds were: 3'methyl-nordihydroguaiaretic acid (MNDGA) 1, nordihydroguaiaretic acid (NDGA) 2 and a NDGA derivative 3, showing strong activity against Trichophyton mentagrophytes, T. rubrum and Microsporum gypseum (MICs between 15.6 and 31.25 μg/mL). The lignans 1 and 2 showed activities against clinical isolates of Candidas spp., Cryptococcus spp., T. rubrum and T. mentagrophytes (MICs and MFCs between 31.25 and 62.5 μg/mL). The lignan and volatile organic compounds (VOCs) profiles from propolis matched with those of exudates of Larrea nitida providing strong evidences on its botanical origin. These results support that Argentinian Andean propolis are a valuable natural product with potential to improve human health. Six compounds (1-6) were isolated from propolis for the first time, while compounds 1 and 3-6 were reported for first time as constituents of L. nitida Cav. © 2011 Elsevier Ltd. Fil:Palermo, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02786915_v49_n9_p1970_Aguero http://hdl.handle.net/20.500.12110/paper_02786915_v49_n9_p1970_Aguero |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Antifungal activity Argentinian Andean propolis GC-MS HPLC-ESI-MS/MS Lignans VOCs 3' methyl nordihydroguaiaretic acid 3,3',4' trihydroxy 4 methoxy 7,7' epoxylignan 3,4,3',4' tetrahydroxy 7,7' epoxylignan acetic acid ethyl ester dichloromethane lignan nordihydroguaiaretic acid nordihydroguaiaretic acid derivative phenol derivative plant medicinal product propolis unclassified drug volatile organic compound Argentina Arthroderma gypseum article Candida controlled study Cryptococcus dermatophyte drug concentration drug determination drug isolation drug screening drug structure fungal strain fungicidal activity high performance liquid chromatography Larrea Larrea nitida mass fragmentography minimum fungicidal concentration minimum inhibitory concentration nonhuman Trichophyton mentagrophytes Trichophyton rubrum Antifungal Agents Chromatography, High Pressure Liquid Gas Chromatography-Mass Spectrometry Larrea Magnetic Resonance Spectroscopy Mass Spectrometry Microbial Sensitivity Tests Propolis Arthroderma benhamiae Arthroderma gypseum Arthrodermataceae Larrea nitida Zygophyllaceae |
| spellingShingle |
Antifungal activity Argentinian Andean propolis GC-MS HPLC-ESI-MS/MS Lignans VOCs 3' methyl nordihydroguaiaretic acid 3,3',4' trihydroxy 4 methoxy 7,7' epoxylignan 3,4,3',4' tetrahydroxy 7,7' epoxylignan acetic acid ethyl ester dichloromethane lignan nordihydroguaiaretic acid nordihydroguaiaretic acid derivative phenol derivative plant medicinal product propolis unclassified drug volatile organic compound Argentina Arthroderma gypseum article Candida controlled study Cryptococcus dermatophyte drug concentration drug determination drug isolation drug screening drug structure fungal strain fungicidal activity high performance liquid chromatography Larrea Larrea nitida mass fragmentography minimum fungicidal concentration minimum inhibitory concentration nonhuman Trichophyton mentagrophytes Trichophyton rubrum Antifungal Agents Chromatography, High Pressure Liquid Gas Chromatography-Mass Spectrometry Larrea Magnetic Resonance Spectroscopy Mass Spectrometry Microbial Sensitivity Tests Propolis Arthroderma benhamiae Arthroderma gypseum Arthrodermataceae Larrea nitida Zygophyllaceae Palermo, Jorge Alejandro Argentinean Andean propolis associated with the medicinal plant Larrea nitida Cav. (Zygophyllaceae). HPLC-MS and GC-MS characterization and antifungal activity |
| topic_facet |
Antifungal activity Argentinian Andean propolis GC-MS HPLC-ESI-MS/MS Lignans VOCs 3' methyl nordihydroguaiaretic acid 3,3',4' trihydroxy 4 methoxy 7,7' epoxylignan 3,4,3',4' tetrahydroxy 7,7' epoxylignan acetic acid ethyl ester dichloromethane lignan nordihydroguaiaretic acid nordihydroguaiaretic acid derivative phenol derivative plant medicinal product propolis unclassified drug volatile organic compound Argentina Arthroderma gypseum article Candida controlled study Cryptococcus dermatophyte drug concentration drug determination drug isolation drug screening drug structure fungal strain fungicidal activity high performance liquid chromatography Larrea Larrea nitida mass fragmentography minimum fungicidal concentration minimum inhibitory concentration nonhuman Trichophyton mentagrophytes Trichophyton rubrum Antifungal Agents Chromatography, High Pressure Liquid Gas Chromatography-Mass Spectrometry Larrea Magnetic Resonance Spectroscopy Mass Spectrometry Microbial Sensitivity Tests Propolis Arthroderma benhamiae Arthroderma gypseum Arthrodermataceae Larrea nitida Zygophyllaceae |
| description |
The chemical profile and botanical origin of Andean Argentinian propolis were studied by HPLC-ESI-MS/MS and GC-MS techniques as well as the antifungal activity according to CLSI protocols. Dermatophytes and yeasts tested were strongly inhibited by propolis extracts (MICs between 31.25 and 125 μg/mL). The main antifungal compounds were: 3'methyl-nordihydroguaiaretic acid (MNDGA) 1, nordihydroguaiaretic acid (NDGA) 2 and a NDGA derivative 3, showing strong activity against Trichophyton mentagrophytes, T. rubrum and Microsporum gypseum (MICs between 15.6 and 31.25 μg/mL). The lignans 1 and 2 showed activities against clinical isolates of Candidas spp., Cryptococcus spp., T. rubrum and T. mentagrophytes (MICs and MFCs between 31.25 and 62.5 μg/mL). The lignan and volatile organic compounds (VOCs) profiles from propolis matched with those of exudates of Larrea nitida providing strong evidences on its botanical origin. These results support that Argentinian Andean propolis are a valuable natural product with potential to improve human health. Six compounds (1-6) were isolated from propolis for the first time, while compounds 1 and 3-6 were reported for first time as constituents of L. nitida Cav. © 2011 Elsevier Ltd. |
| author |
Palermo, Jorge Alejandro |
| author_facet |
Palermo, Jorge Alejandro |
| author_sort |
Palermo, Jorge Alejandro |
| title |
Argentinean Andean propolis associated with the medicinal plant Larrea nitida Cav. (Zygophyllaceae). HPLC-MS and GC-MS characterization and antifungal activity |
| title_short |
Argentinean Andean propolis associated with the medicinal plant Larrea nitida Cav. (Zygophyllaceae). HPLC-MS and GC-MS characterization and antifungal activity |
| title_full |
Argentinean Andean propolis associated with the medicinal plant Larrea nitida Cav. (Zygophyllaceae). HPLC-MS and GC-MS characterization and antifungal activity |
| title_fullStr |
Argentinean Andean propolis associated with the medicinal plant Larrea nitida Cav. (Zygophyllaceae). HPLC-MS and GC-MS characterization and antifungal activity |
| title_full_unstemmed |
Argentinean Andean propolis associated with the medicinal plant Larrea nitida Cav. (Zygophyllaceae). HPLC-MS and GC-MS characterization and antifungal activity |
| title_sort |
argentinean andean propolis associated with the medicinal plant larrea nitida cav. (zygophyllaceae). hplc-ms and gc-ms characterization and antifungal activity |
| publishDate |
2011 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02786915_v49_n9_p1970_Aguero http://hdl.handle.net/20.500.12110/paper_02786915_v49_n9_p1970_Aguero |
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AT palermojorgealejandro argentineanandeanpropolisassociatedwiththemedicinalplantlarreanitidacavzygophyllaceaehplcmsandgcmscharacterizationandantifungalactivity |
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