Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory
Memory consolidation requires gene expression regulation by transcription factors, which eventually may induce chromatin modifications as histone acetylation. This mechanism is regulated by histone acetylases and deacetylases. It is not yet clear whether memory consolidation always recruits histone...
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2013
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v33_n17_p7603_Federman http://hdl.handle.net/20.500.12110/paper_02706474_v33_n17_p7603_Federman |
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paper:paper_02706474_v33_n17_p7603_Federman2023-06-08T15:24:50Z Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory calcium calmodulin dependent protein kinase II histone H3 immunoglobulin enhancer binding protein animal experiment article behavior chromatin immunoprecipitation controlled study gene expression histone acetylation male memory mouse nonhuman pattern recognition priority journal protein expression real time polymerase chain reaction task performance training Western blotting Acetylation Animals Histone Acetyltransferases Histones Learning Male Memory Mice Mice, Inbred C57BL NF-kappa B Recognition (Psychology) Memory consolidation requires gene expression regulation by transcription factors, which eventually may induce chromatin modifications as histone acetylation. This mechanism is regulated by histone acetylases and deacetylases. It is not yet clear whether memory consolidation always recruits histone acetylation or it is only engaged in more persistent memories. To address this question, we used different strength of training for novel object recognition task in mice. Only strong training induced a long-lasting memory and an increase in hippocampal histone H3 acetylation. Histone acetylase inhibition in the hippocampus during consolidation impaired memory persistence, whereas histone deacetylase inhibition caused weak memory to persist. Nuclear factor κB (NF-κB) transcription factor inhibition impaired memory persistence and, concomitantly, reduced the general level of H3 acetylation. Accordingly, we found an important increase in H3 acetylation at a specific NF-κB-regulated promoter region of the Camk2d gene, which was reversed by NF-kB inhibition. These results show for the first time that histone acetylation is a specific molecular signature of enduring memories. ©2013 the authors. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v33_n17_p7603_Federman http://hdl.handle.net/20.500.12110/paper_02706474_v33_n17_p7603_Federman |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
calcium calmodulin dependent protein kinase II histone H3 immunoglobulin enhancer binding protein animal experiment article behavior chromatin immunoprecipitation controlled study gene expression histone acetylation male memory mouse nonhuman pattern recognition priority journal protein expression real time polymerase chain reaction task performance training Western blotting Acetylation Animals Histone Acetyltransferases Histones Learning Male Memory Mice Mice, Inbred C57BL NF-kappa B Recognition (Psychology) |
| spellingShingle |
calcium calmodulin dependent protein kinase II histone H3 immunoglobulin enhancer binding protein animal experiment article behavior chromatin immunoprecipitation controlled study gene expression histone acetylation male memory mouse nonhuman pattern recognition priority journal protein expression real time polymerase chain reaction task performance training Western blotting Acetylation Animals Histone Acetyltransferases Histones Learning Male Memory Mice Mice, Inbred C57BL NF-kappa B Recognition (Psychology) Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory |
| topic_facet |
calcium calmodulin dependent protein kinase II histone H3 immunoglobulin enhancer binding protein animal experiment article behavior chromatin immunoprecipitation controlled study gene expression histone acetylation male memory mouse nonhuman pattern recognition priority journal protein expression real time polymerase chain reaction task performance training Western blotting Acetylation Animals Histone Acetyltransferases Histones Learning Male Memory Mice Mice, Inbred C57BL NF-kappa B Recognition (Psychology) |
| description |
Memory consolidation requires gene expression regulation by transcription factors, which eventually may induce chromatin modifications as histone acetylation. This mechanism is regulated by histone acetylases and deacetylases. It is not yet clear whether memory consolidation always recruits histone acetylation or it is only engaged in more persistent memories. To address this question, we used different strength of training for novel object recognition task in mice. Only strong training induced a long-lasting memory and an increase in hippocampal histone H3 acetylation. Histone acetylase inhibition in the hippocampus during consolidation impaired memory persistence, whereas histone deacetylase inhibition caused weak memory to persist. Nuclear factor κB (NF-κB) transcription factor inhibition impaired memory persistence and, concomitantly, reduced the general level of H3 acetylation. Accordingly, we found an important increase in H3 acetylation at a specific NF-κB-regulated promoter region of the Camk2d gene, which was reversed by NF-kB inhibition. These results show for the first time that histone acetylation is a specific molecular signature of enduring memories. ©2013 the authors. |
| title |
Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory |
| title_short |
Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory |
| title_full |
Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory |
| title_fullStr |
Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory |
| title_full_unstemmed |
Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory |
| title_sort |
nuclear factor κb-dependent histone acetylation is specifically involved in persistent forms of memory |
| publishDate |
2013 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v33_n17_p7603_Federman http://hdl.handle.net/20.500.12110/paper_02706474_v33_n17_p7603_Federman |
| _version_ |
1768543558489341952 |