A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells
Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell. It has been proposed that calcium-induced calcium release (CIC...
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2004
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v24_n49_p11160_Lioudyno http://hdl.handle.net/20.500.12110/paper_02706474_v24_n49_p11160_Lioudyno |
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paper:paper_02706474_v24_n49_p11160_Lioudyno2025-07-30T18:02:43Z A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells Acetylcholine Calcium Cochlea Hair cell Inhibition Nicotinic acetylcholine ryanodine receptor ryanodine receptor 1 unclassified drug amplitude modulation animal experiment article cochlea controlled study hair cell nonhuman priority journal protein expression rat sarcoplasmic reticulum synaptic membrane Acetylcholine Animals Calcium Electrophysiology Endoplasmic Reticulum Evoked Potentials Hair Cells Neural Inhibition Patch-Clamp Techniques Potassium Rats Rats, Sprague-Dawley Receptors, Nicotinic Ryanodine Receptor Calcium Release Channel Synapses Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell. It has been proposed that calcium-induced calcium release (CICR) from a near-membrane postsynaptic store supplements this process. Here, we demonstrate expression of type I ryanodine receptors in outer hair cells in the apical turn of the rat cochlea. Consistent with this finding, ryanodine and other store-active compounds alter the amplitude of transient currents produced by synaptic release of ACh, as well as the response of the hair cell to exogenous ACh. Like the sarcoplasmic reticulum of muscle, the "synaptoplasmic" cistern of the hair cell efficiently couples synaptic input to CICR. 2004 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v24_n49_p11160_Lioudyno http://hdl.handle.net/20.500.12110/paper_02706474_v24_n49_p11160_Lioudyno |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Acetylcholine Calcium Cochlea Hair cell Inhibition Nicotinic acetylcholine ryanodine receptor ryanodine receptor 1 unclassified drug amplitude modulation animal experiment article cochlea controlled study hair cell nonhuman priority journal protein expression rat sarcoplasmic reticulum synaptic membrane Acetylcholine Animals Calcium Electrophysiology Endoplasmic Reticulum Evoked Potentials Hair Cells Neural Inhibition Patch-Clamp Techniques Potassium Rats Rats, Sprague-Dawley Receptors, Nicotinic Ryanodine Receptor Calcium Release Channel Synapses |
| spellingShingle |
Acetylcholine Calcium Cochlea Hair cell Inhibition Nicotinic acetylcholine ryanodine receptor ryanodine receptor 1 unclassified drug amplitude modulation animal experiment article cochlea controlled study hair cell nonhuman priority journal protein expression rat sarcoplasmic reticulum synaptic membrane Acetylcholine Animals Calcium Electrophysiology Endoplasmic Reticulum Evoked Potentials Hair Cells Neural Inhibition Patch-Clamp Techniques Potassium Rats Rats, Sprague-Dawley Receptors, Nicotinic Ryanodine Receptor Calcium Release Channel Synapses A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells |
| topic_facet |
Acetylcholine Calcium Cochlea Hair cell Inhibition Nicotinic acetylcholine ryanodine receptor ryanodine receptor 1 unclassified drug amplitude modulation animal experiment article cochlea controlled study hair cell nonhuman priority journal protein expression rat sarcoplasmic reticulum synaptic membrane Acetylcholine Animals Calcium Electrophysiology Endoplasmic Reticulum Evoked Potentials Hair Cells Neural Inhibition Patch-Clamp Techniques Potassium Rats Rats, Sprague-Dawley Receptors, Nicotinic Ryanodine Receptor Calcium Release Channel Synapses |
| description |
Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell. It has been proposed that calcium-induced calcium release (CICR) from a near-membrane postsynaptic store supplements this process. Here, we demonstrate expression of type I ryanodine receptors in outer hair cells in the apical turn of the rat cochlea. Consistent with this finding, ryanodine and other store-active compounds alter the amplitude of transient currents produced by synaptic release of ACh, as well as the response of the hair cell to exogenous ACh. Like the sarcoplasmic reticulum of muscle, the "synaptoplasmic" cistern of the hair cell efficiently couples synaptic input to CICR. |
| title |
A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells |
| title_short |
A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells |
| title_full |
A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells |
| title_fullStr |
A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells |
| title_full_unstemmed |
A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells |
| title_sort |
"synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells |
| publishDate |
2004 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v24_n49_p11160_Lioudyno http://hdl.handle.net/20.500.12110/paper_02706474_v24_n49_p11160_Lioudyno |
| _version_ |
1840323849244114944 |