The dopamine D 2 , but not D 3 or D 4 , receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice
Brain dopamine (DA) systems are involved in the modulation of the sensorimotor gating phenomenon known as prepulse inhibition (PPI). The class of D 2 -like receptors, including the D2, D3, and D4 receptor subtypes, have all been implicated in the control of PPI via studies of DA agonists and antagon...
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1999
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v19_n11_p4627_Ralph http://hdl.handle.net/20.500.12110/paper_02706474_v19_n11_p4627_Ralph |
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paper:paper_02706474_v19_n11_p4627_Ralph2023-06-08T15:24:42Z The dopamine D 2 , but not D 3 or D 4 , receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice Amphetamine Dopamine receptors Genetics Mice Prepulse inhibition Startle dexamphetamine dopamine dopamine 2 receptor dopamine 3 receptor dopamine 4 receptor ligand neuroleptic agent receptor subtype amphetamine dopamine 2 receptor dopamine 3 receptor dopamine 4 receptor dopamine receptor dopamine receptor stimulating agent Drd3 protein, mouse Drd4 protein, mouse animal experiment article controlled study drug mechanism female genotype knockout mouse male mouse nonhuman phenotype prepulse inhibition priority journal schizophrenia sensorimotor function startle reflex animal auditory stimulation drug effect mouse mutant nerve cell inhibition startle reflex Acoustic Stimulation Amphetamine Animals Dopamine Agents Mice Mice, Knockout Mice, Mutant Strains Neural Inhibition Receptors, Dopamine Receptors, Dopamine D2 Receptors, Dopamine D3 Receptors, Dopamine D4 Startle Reaction Brain dopamine (DA) systems are involved in the modulation of the sensorimotor gating phenomenon known as prepulse inhibition (PPI). The class of D 2 -like receptors, including the D2, D3, and D4 receptor subtypes, have all been implicated in the control of PPI via studies of DA agonists and antagonists in rats. Nevertheless, the functional relevance of each receptor subtype remains unclear because these ligands are not specific. To determine the relevance of each receptor subtype, we used genetically altered strains of 'knock-out' mice lacking the DA D2, D3, or D4 receptors. We tested the effects of each knock-out on both the phenotypic expression of PPI and the disruption of PPI produced by the indirect DA agonist d-amphetamine (AMPH). No phenotypic differences in PPI were observed at baseline. AMPH significantly disrupted PPI in the D2 (+/+) mice but had no effect in the D2 (-/-) mice. After AMPH treatment, both DA D3 and D4 receptor (+/+) and (-/-) mice had significant disruptions in PPI. These findings indicate that the AMPH-induced disruption of PPI is mediated via the DA D2 receptor and not the D3 or D4 receptor subtypes. Uncovering the neural mechanisms involved in PPI will further our understanding of the substrates of sensorimotor gating and could lead to better therapeutics to treat gating disorders, such as schizophrenia. 1999 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v19_n11_p4627_Ralph http://hdl.handle.net/20.500.12110/paper_02706474_v19_n11_p4627_Ralph |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Amphetamine Dopamine receptors Genetics Mice Prepulse inhibition Startle dexamphetamine dopamine dopamine 2 receptor dopamine 3 receptor dopamine 4 receptor ligand neuroleptic agent receptor subtype amphetamine dopamine 2 receptor dopamine 3 receptor dopamine 4 receptor dopamine receptor dopamine receptor stimulating agent Drd3 protein, mouse Drd4 protein, mouse animal experiment article controlled study drug mechanism female genotype knockout mouse male mouse nonhuman phenotype prepulse inhibition priority journal schizophrenia sensorimotor function startle reflex animal auditory stimulation drug effect mouse mutant nerve cell inhibition startle reflex Acoustic Stimulation Amphetamine Animals Dopamine Agents Mice Mice, Knockout Mice, Mutant Strains Neural Inhibition Receptors, Dopamine Receptors, Dopamine D2 Receptors, Dopamine D3 Receptors, Dopamine D4 Startle Reaction |
| spellingShingle |
Amphetamine Dopamine receptors Genetics Mice Prepulse inhibition Startle dexamphetamine dopamine dopamine 2 receptor dopamine 3 receptor dopamine 4 receptor ligand neuroleptic agent receptor subtype amphetamine dopamine 2 receptor dopamine 3 receptor dopamine 4 receptor dopamine receptor dopamine receptor stimulating agent Drd3 protein, mouse Drd4 protein, mouse animal experiment article controlled study drug mechanism female genotype knockout mouse male mouse nonhuman phenotype prepulse inhibition priority journal schizophrenia sensorimotor function startle reflex animal auditory stimulation drug effect mouse mutant nerve cell inhibition startle reflex Acoustic Stimulation Amphetamine Animals Dopamine Agents Mice Mice, Knockout Mice, Mutant Strains Neural Inhibition Receptors, Dopamine Receptors, Dopamine D2 Receptors, Dopamine D3 Receptors, Dopamine D4 Startle Reaction The dopamine D 2 , but not D 3 or D 4 , receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice |
| topic_facet |
Amphetamine Dopamine receptors Genetics Mice Prepulse inhibition Startle dexamphetamine dopamine dopamine 2 receptor dopamine 3 receptor dopamine 4 receptor ligand neuroleptic agent receptor subtype amphetamine dopamine 2 receptor dopamine 3 receptor dopamine 4 receptor dopamine receptor dopamine receptor stimulating agent Drd3 protein, mouse Drd4 protein, mouse animal experiment article controlled study drug mechanism female genotype knockout mouse male mouse nonhuman phenotype prepulse inhibition priority journal schizophrenia sensorimotor function startle reflex animal auditory stimulation drug effect mouse mutant nerve cell inhibition startle reflex Acoustic Stimulation Amphetamine Animals Dopamine Agents Mice Mice, Knockout Mice, Mutant Strains Neural Inhibition Receptors, Dopamine Receptors, Dopamine D2 Receptors, Dopamine D3 Receptors, Dopamine D4 Startle Reaction |
| description |
Brain dopamine (DA) systems are involved in the modulation of the sensorimotor gating phenomenon known as prepulse inhibition (PPI). The class of D 2 -like receptors, including the D2, D3, and D4 receptor subtypes, have all been implicated in the control of PPI via studies of DA agonists and antagonists in rats. Nevertheless, the functional relevance of each receptor subtype remains unclear because these ligands are not specific. To determine the relevance of each receptor subtype, we used genetically altered strains of 'knock-out' mice lacking the DA D2, D3, or D4 receptors. We tested the effects of each knock-out on both the phenotypic expression of PPI and the disruption of PPI produced by the indirect DA agonist d-amphetamine (AMPH). No phenotypic differences in PPI were observed at baseline. AMPH significantly disrupted PPI in the D2 (+/+) mice but had no effect in the D2 (-/-) mice. After AMPH treatment, both DA D3 and D4 receptor (+/+) and (-/-) mice had significant disruptions in PPI. These findings indicate that the AMPH-induced disruption of PPI is mediated via the DA D2 receptor and not the D3 or D4 receptor subtypes. Uncovering the neural mechanisms involved in PPI will further our understanding of the substrates of sensorimotor gating and could lead to better therapeutics to treat gating disorders, such as schizophrenia. |
| title |
The dopamine D 2 , but not D 3 or D 4 , receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice |
| title_short |
The dopamine D 2 , but not D 3 or D 4 , receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice |
| title_full |
The dopamine D 2 , but not D 3 or D 4 , receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice |
| title_fullStr |
The dopamine D 2 , but not D 3 or D 4 , receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice |
| title_full_unstemmed |
The dopamine D 2 , but not D 3 or D 4 , receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice |
| title_sort |
dopamine d 2 , but not d 3 or d 4 , receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice |
| publishDate |
1999 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02706474_v19_n11_p4627_Ralph http://hdl.handle.net/20.500.12110/paper_02706474_v19_n11_p4627_Ralph |
| _version_ |
1768544408083365888 |