Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus

Parasitic illnesses is increasing all over the world, especially in developing countries, and metronidazole (MTZ) is the therapeutic agent usually administered to children as well as adults at the reproductive age. In this work, we propose an evaluation of MTZ in order to analyze the potential repro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Publicado:	2001
Materias:	Dominant lethality Maternal exposure Nitroimidazole Post-implantation death metronidazole animal experiment animal model animal tissue article controlled study embryotoxicity environmental exposure female gestational age mortality nidation nonhuman phenotype priority journal rat reproduction Animals Antitrichomonal Agents Embryo Embryo Implantation Embryo Loss Embryonic Development Female Fertility Fetal Death Fetus Maternal Exposure Metronidazole Pregnancy Rats Rats, Sprague-Dawley Reproduction Animalia Rattus norvegicus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02703211_v21_n3_p197_Mudry http://hdl.handle.net/20.500.12110/paper_02703211_v21_n3_p197_Mudry
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_02703211_v21_n3_p197_Mudry
record_format	dspace
spelling	paper:paper_02703211_v21_n3_p197_Mudry2023-06-08T15:24:36Z Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus Dominant lethality Maternal exposure Nitroimidazole Post-implantation death metronidazole animal experiment animal model animal tissue article controlled study embryotoxicity environmental exposure female gestational age mortality nidation nonhuman phenotype priority journal rat reproduction Animals Antitrichomonal Agents Embryo Embryo Implantation Embryo Loss Embryonic Development Female Fertility Fetal Death Fetus Maternal Exposure Metronidazole Pregnancy Rats Rats, Sprague-Dawley Reproduction Animalia Rattus norvegicus Parasitic illnesses is increasing all over the world, especially in developing countries, and metronidazole (MTZ) is the therapeutic agent usually administered to children as well as adults at the reproductive age. In this work, we propose an evaluation of MTZ in order to analyze the potential reproductive damage in females by using Rattus norvegicus (Sprague-Dawley) as an animal model. Adult female rats were mated after MTZ treatments, and they were sacrificed at 21 days of gestation. Different types of damage were evaluated by using mortality, phenotypic abnormalities and reproductive capacity as parameters, and were studied and scored in 70 adult specimens (450 g/bw). They were divided into five groups: a) untreated females as a control group; females treated with b) DMSO as a solvent control group or c) 500 mg/kg/bw of MTZ per day for 7 days as therapeutic dose (TD); d) a half therapeutic dose (HD); and e) a double therapeutic dose (DD). Pre-implantation death in MTZ-treated groups was not significantly different from controls. However, drug treatments significantly increased the frequency of post-implantation deaths and the dominant lethals were ranged between 12.0 % and 17.8 %. © 2001 Wiley-Liss, Inc. 2001 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02703211_v21_n3_p197_Mudry http://hdl.handle.net/20.500.12110/paper_02703211_v21_n3_p197_Mudry
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Dominant lethality Maternal exposure Nitroimidazole Post-implantation death metronidazole animal experiment animal model animal tissue article controlled study embryotoxicity environmental exposure female gestational age mortality nidation nonhuman phenotype priority journal rat reproduction Animals Antitrichomonal Agents Embryo Embryo Implantation Embryo Loss Embryonic Development Female Fertility Fetal Death Fetus Maternal Exposure Metronidazole Pregnancy Rats Rats, Sprague-Dawley Reproduction Animalia Rattus norvegicus
spellingShingle	Dominant lethality Maternal exposure Nitroimidazole Post-implantation death metronidazole animal experiment animal model animal tissue article controlled study embryotoxicity environmental exposure female gestational age mortality nidation nonhuman phenotype priority journal rat reproduction Animals Antitrichomonal Agents Embryo Embryo Implantation Embryo Loss Embryonic Development Female Fertility Fetal Death Fetus Maternal Exposure Metronidazole Pregnancy Rats Rats, Sprague-Dawley Reproduction Animalia Rattus norvegicus Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus
topic_facet	Dominant lethality Maternal exposure Nitroimidazole Post-implantation death metronidazole animal experiment animal model animal tissue article controlled study embryotoxicity environmental exposure female gestational age mortality nidation nonhuman phenotype priority journal rat reproduction Animals Antitrichomonal Agents Embryo Embryo Implantation Embryo Loss Embryonic Development Female Fertility Fetal Death Fetus Maternal Exposure Metronidazole Pregnancy Rats Rats, Sprague-Dawley Reproduction Animalia Rattus norvegicus
description	Parasitic illnesses is increasing all over the world, especially in developing countries, and metronidazole (MTZ) is the therapeutic agent usually administered to children as well as adults at the reproductive age. In this work, we propose an evaluation of MTZ in order to analyze the potential reproductive damage in females by using Rattus norvegicus (Sprague-Dawley) as an animal model. Adult female rats were mated after MTZ treatments, and they were sacrificed at 21 days of gestation. Different types of damage were evaluated by using mortality, phenotypic abnormalities and reproductive capacity as parameters, and were studied and scored in 70 adult specimens (450 g/bw). They were divided into five groups: a) untreated females as a control group; females treated with b) DMSO as a solvent control group or c) 500 mg/kg/bw of MTZ per day for 7 days as therapeutic dose (TD); d) a half therapeutic dose (HD); and e) a double therapeutic dose (DD). Pre-implantation death in MTZ-treated groups was not significantly different from controls. However, drug treatments significantly increased the frequency of post-implantation deaths and the dominant lethals were ranged between 12.0 % and 17.8 %. © 2001 Wiley-Liss, Inc.
title	Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus
title_short	Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus
title_full	Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus
title_fullStr	Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus
title_full_unstemmed	Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus
title_sort	embryolethality induced by metronidazole (mtz) in rattus norvegicus
publishDate	2001
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02703211_v21_n3_p197_Mudry http://hdl.handle.net/20.500.12110/paper_02703211_v21_n3_p197_Mudry
_version_	1768543797523775488

Embryolethality induced by metronidazole (MTZ) in Rattus norvegicus

Ejemplares similares