Porphyrins and porphyrinogen carboxy-lyase in hexachlorobenzene induced porphyria
Qualitative and quantitative studies of the porphyrins and the porphyrinogen carboxylyase of the liver, spleen, kidney, Harderian gland and erythrocytes from normal rats and from those with hexachlorobenzene-induced porphyria were carried out. Hexachlorobenzene has no effect on erythrocyte porphyrin...
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1977
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02646021_v168_n3_p393_SanMartinDeViale http://hdl.handle.net/20.500.12110/paper_02646021_v168_n3_p393_SanMartinDeViale |
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paper:paper_02646021_v168_n3_p393_SanMartinDeViale2023-06-08T15:23:04Z Porphyrins and porphyrinogen carboxy-lyase in hexachlorobenzene induced porphyria carboxylase hexachlorobenzene porphyrin porphyrinogen erythrocyte erythropoiesis Harder gland kidney liver porphyria rat spleen theoretical study Qualitative and quantitative studies of the porphyrins and the porphyrinogen carboxylyase of the liver, spleen, kidney, Harderian gland and erythrocytes from normal rats and from those with hexachlorobenzene-induced porphyria were carried out. Hexachlorobenzene has no effect on erythrocyte porphyrin content, but produces a decrease in that of Harderian gland and an increase in the porphyrin content of the kidney and spleen, and a marked increase in the liver (1 μmol/g of tissue). Octacarboxylic (isomer III) and heptacarboxylic porphyrins accumulated in kidney, spleen and liver, the former porphyrin being predominant. Hexachlorobenzene has no effect on the activity of porphyrinogen carboxy-lyase in erythrocytes; there is a slight decrease in enzyme activity in the Harderian gland, and a marked decrease in the liver and kidney enzyme activities. In the liver the removal of each carboxyl group from uroporphyrinogen III appears to be affected by this treatment. The liver is the principal site of action of hexachlorobenzene, with the kidney next in decreasing order of effect, and erythropoietic tissue is unaffected. The marked decrease in porphyrinogen carboxy-lyase activities observed in liver and kidney could explain the high accumulation of octacarboxylic and heptacarboxylic porphyrins found in these tissues. The results are discussed in relation to changes promoted by hexachlorobenzene in other enzymes of the haem pathway. 1977 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02646021_v168_n3_p393_SanMartinDeViale http://hdl.handle.net/20.500.12110/paper_02646021_v168_n3_p393_SanMartinDeViale |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
carboxylase hexachlorobenzene porphyrin porphyrinogen erythrocyte erythropoiesis Harder gland kidney liver porphyria rat spleen theoretical study |
| spellingShingle |
carboxylase hexachlorobenzene porphyrin porphyrinogen erythrocyte erythropoiesis Harder gland kidney liver porphyria rat spleen theoretical study Porphyrins and porphyrinogen carboxy-lyase in hexachlorobenzene induced porphyria |
| topic_facet |
carboxylase hexachlorobenzene porphyrin porphyrinogen erythrocyte erythropoiesis Harder gland kidney liver porphyria rat spleen theoretical study |
| description |
Qualitative and quantitative studies of the porphyrins and the porphyrinogen carboxylyase of the liver, spleen, kidney, Harderian gland and erythrocytes from normal rats and from those with hexachlorobenzene-induced porphyria were carried out. Hexachlorobenzene has no effect on erythrocyte porphyrin content, but produces a decrease in that of Harderian gland and an increase in the porphyrin content of the kidney and spleen, and a marked increase in the liver (1 μmol/g of tissue). Octacarboxylic (isomer III) and heptacarboxylic porphyrins accumulated in kidney, spleen and liver, the former porphyrin being predominant. Hexachlorobenzene has no effect on the activity of porphyrinogen carboxy-lyase in erythrocytes; there is a slight decrease in enzyme activity in the Harderian gland, and a marked decrease in the liver and kidney enzyme activities. In the liver the removal of each carboxyl group from uroporphyrinogen III appears to be affected by this treatment. The liver is the principal site of action of hexachlorobenzene, with the kidney next in decreasing order of effect, and erythropoietic tissue is unaffected. The marked decrease in porphyrinogen carboxy-lyase activities observed in liver and kidney could explain the high accumulation of octacarboxylic and heptacarboxylic porphyrins found in these tissues. The results are discussed in relation to changes promoted by hexachlorobenzene in other enzymes of the haem pathway. |
| title |
Porphyrins and porphyrinogen carboxy-lyase in hexachlorobenzene induced porphyria |
| title_short |
Porphyrins and porphyrinogen carboxy-lyase in hexachlorobenzene induced porphyria |
| title_full |
Porphyrins and porphyrinogen carboxy-lyase in hexachlorobenzene induced porphyria |
| title_fullStr |
Porphyrins and porphyrinogen carboxy-lyase in hexachlorobenzene induced porphyria |
| title_full_unstemmed |
Porphyrins and porphyrinogen carboxy-lyase in hexachlorobenzene induced porphyria |
| title_sort |
porphyrins and porphyrinogen carboxy-lyase in hexachlorobenzene induced porphyria |
| publishDate |
1977 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02646021_v168_n3_p393_SanMartinDeViale http://hdl.handle.net/20.500.12110/paper_02646021_v168_n3_p393_SanMartinDeViale |
| _version_ |
1768546207079071744 |