The efflux from and the metabolism of 3H-norepinephrine in sow graafian follicles. Variable involvement of some prostaglandins during two different stages of the sex cycle

The influences of acetylsalicylic acid (ASA) and of prostaglandins (PGs) E1, E2 or F2α metabolism the spontaneous total tritium efflux from and on the metabolism of 3H-norepinephrine (3H-NE) in the walls of sow Graafian follicles isolated during two different stages of the sex cycle, were studied. T...

Descripción completa

Guardado en:

Detalles Bibliográficos
Publicado:	1985
Materias:	acetylsalicylic acid noradrenalin prostaglandin derivative prostaglandin E prostaglandin E1 prostaglandin E2 prostaglandin F prostaglandin F2 alpha prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha radioisotope animal article diestrus drug effect estrus female in vitro study metabolism ovary follicle pregnancy proestrus swine cattle drug accumulation drug efficacy endocrine system female genital system nonhuman noradrenalin h 3 ovary priority journal sexual cycle Alprostadil Animal Aspirin Diestrus Dinoprost Dinoprostone Estrus Female In Vitro Norepinephrine Ovarian Follicle Pregnancy Proestrus Prostaglandins E Prostaglandins F Prostaglandins, Synthetic Support, Non-U.S. Gov't Swine
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v19_n1_p1_FernandezPardal http://hdl.handle.net/20.500.12110/paper_02621746_v19_n1_p1_FernandezPardal
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_02621746_v19_n1_p1_FernandezPardal
record_format	dspace
spelling	paper:paper_02621746_v19_n1_p1_FernandezPardal2023-06-08T15:22:51Z The efflux from and the metabolism of 3H-norepinephrine in sow graafian follicles. Variable involvement of some prostaglandins during two different stages of the sex cycle acetylsalicylic acid noradrenalin prostaglandin derivative prostaglandin E prostaglandin E1 prostaglandin E2 prostaglandin F prostaglandin F2 alpha acetylsalicylic acid noradrenalin prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha radioisotope animal article diestrus drug effect estrus female in vitro study metabolism ovary follicle pregnancy proestrus swine cattle drug accumulation drug efficacy endocrine system female genital system nonhuman noradrenalin h 3 ovary ovary follicle priority journal sexual cycle Alprostadil Animal Aspirin Diestrus Dinoprost Dinoprostone Estrus Female In Vitro Norepinephrine Ovarian Follicle Pregnancy Proestrus Prostaglandins E Prostaglandins F Prostaglandins, Synthetic Support, Non-U.S. Gov't Swine The influences of acetylsalicylic acid (ASA) and of prostaglandins (PGs) E1, E2 or F2α metabolism the spontaneous total tritium efflux from and on the metabolism of 3H-norepinephrine (3H-NE) in the walls of sow Graafian follicles isolated during two different stages of the sex cycle, were studied. The total 3H efflux from preparations obtained in proestrus (early preovulatory period) was higher than the output from diestrous tissues. This augmentation observed in proestrous samples, mainly attributable to a greater metabolism of 3H-NE, was expressed by an enhanced 3H-efflux corresponding to 3H-0-methylated (3H-OMDA) and 3H-normetanephrine (3H-NMN) metabolites. With regard to 3H-labelled compounds retained in the tissue, the follicular walls in proestrus (as compared to those in diestrus), retained more 3H-NMN fraction and less 3H-NE; an augmented metabolism of 3H-NE is suggested for the proestrous follicles. In the presence of ASA (2.2 × 10-4 M) the above mentioned profiles of early preovulatory follicles, disappeared and the addition in vitro of PGE1 or PGE2 (10-8 M), but not of PGF2α (10-8 M to 10-6 m) was able to reverse the influence of ASA. These findings suggest the involvement of estrogens in the metabolism of 3H-NE by sow ovarian follicles and moreover, they also appear to indicate the requirement for some PGs, such as PGE1 and PGE2, generated by cells of the follicular wall. © 1985. 1985 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v19_n1_p1_FernandezPardal http://hdl.handle.net/20.500.12110/paper_02621746_v19_n1_p1_FernandezPardal
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	acetylsalicylic acid noradrenalin prostaglandin derivative prostaglandin E prostaglandin E1 prostaglandin E2 prostaglandin F prostaglandin F2 alpha acetylsalicylic acid noradrenalin prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha radioisotope animal article diestrus drug effect estrus female in vitro study metabolism ovary follicle pregnancy proestrus swine cattle drug accumulation drug efficacy endocrine system female genital system nonhuman noradrenalin h 3 ovary ovary follicle priority journal sexual cycle Alprostadil Animal Aspirin Diestrus Dinoprost Dinoprostone Estrus Female In Vitro Norepinephrine Ovarian Follicle Pregnancy Proestrus Prostaglandins E Prostaglandins F Prostaglandins, Synthetic Support, Non-U.S. Gov't Swine
spellingShingle	acetylsalicylic acid noradrenalin prostaglandin derivative prostaglandin E prostaglandin E1 prostaglandin E2 prostaglandin F prostaglandin F2 alpha acetylsalicylic acid noradrenalin prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha radioisotope animal article diestrus drug effect estrus female in vitro study metabolism ovary follicle pregnancy proestrus swine cattle drug accumulation drug efficacy endocrine system female genital system nonhuman noradrenalin h 3 ovary ovary follicle priority journal sexual cycle Alprostadil Animal Aspirin Diestrus Dinoprost Dinoprostone Estrus Female In Vitro Norepinephrine Ovarian Follicle Pregnancy Proestrus Prostaglandins E Prostaglandins F Prostaglandins, Synthetic Support, Non-U.S. Gov't Swine The efflux from and the metabolism of 3H-norepinephrine in sow graafian follicles. Variable involvement of some prostaglandins during two different stages of the sex cycle
topic_facet	acetylsalicylic acid noradrenalin prostaglandin derivative prostaglandin E prostaglandin E1 prostaglandin E2 prostaglandin F prostaglandin F2 alpha acetylsalicylic acid noradrenalin prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha radioisotope animal article diestrus drug effect estrus female in vitro study metabolism ovary follicle pregnancy proestrus swine cattle drug accumulation drug efficacy endocrine system female genital system nonhuman noradrenalin h 3 ovary ovary follicle priority journal sexual cycle Alprostadil Animal Aspirin Diestrus Dinoprost Dinoprostone Estrus Female In Vitro Norepinephrine Ovarian Follicle Pregnancy Proestrus Prostaglandins E Prostaglandins F Prostaglandins, Synthetic Support, Non-U.S. Gov't Swine
description	The influences of acetylsalicylic acid (ASA) and of prostaglandins (PGs) E1, E2 or F2α metabolism the spontaneous total tritium efflux from and on the metabolism of 3H-norepinephrine (3H-NE) in the walls of sow Graafian follicles isolated during two different stages of the sex cycle, were studied. The total 3H efflux from preparations obtained in proestrus (early preovulatory period) was higher than the output from diestrous tissues. This augmentation observed in proestrous samples, mainly attributable to a greater metabolism of 3H-NE, was expressed by an enhanced 3H-efflux corresponding to 3H-0-methylated (3H-OMDA) and 3H-normetanephrine (3H-NMN) metabolites. With regard to 3H-labelled compounds retained in the tissue, the follicular walls in proestrus (as compared to those in diestrus), retained more 3H-NMN fraction and less 3H-NE; an augmented metabolism of 3H-NE is suggested for the proestrous follicles. In the presence of ASA (2.2 × 10-4 M) the above mentioned profiles of early preovulatory follicles, disappeared and the addition in vitro of PGE1 or PGE2 (10-8 M), but not of PGF2α (10-8 M to 10-6 m) was able to reverse the influence of ASA. These findings suggest the involvement of estrogens in the metabolism of 3H-NE by sow ovarian follicles and moreover, they also appear to indicate the requirement for some PGs, such as PGE1 and PGE2, generated by cells of the follicular wall. © 1985.
title	The efflux from and the metabolism of 3H-norepinephrine in sow graafian follicles. Variable involvement of some prostaglandins during two different stages of the sex cycle
title_short	The efflux from and the metabolism of 3H-norepinephrine in sow graafian follicles. Variable involvement of some prostaglandins during two different stages of the sex cycle
title_full	The efflux from and the metabolism of 3H-norepinephrine in sow graafian follicles. Variable involvement of some prostaglandins during two different stages of the sex cycle
title_fullStr	The efflux from and the metabolism of 3H-norepinephrine in sow graafian follicles. Variable involvement of some prostaglandins during two different stages of the sex cycle
title_full_unstemmed	The efflux from and the metabolism of 3H-norepinephrine in sow graafian follicles. Variable involvement of some prostaglandins during two different stages of the sex cycle
title_sort	efflux from and the metabolism of 3h-norepinephrine in sow graafian follicles. variable involvement of some prostaglandins during two different stages of the sex cycle
publishDate	1985
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v19_n1_p1_FernandezPardal http://hdl.handle.net/20.500.12110/paper_02621746_v19_n1_p1_FernandezPardal
_version_	1768542457254903808

The efflux from and the metabolism of 3H-norepinephrine in sow graafian follicles. Variable involvement of some prostaglandins during two different stages of the sex cycle

Ejemplares similares