Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis

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Introduction: Epidemiological studies have demonstrated that patients with diabetes mellitus have an increased risk of developing Alzheimer disease, but the relationship between the 2 entities is not clear. Development: Both diseases exhibit similar metabolic abnormalities: disordered glucose metabo...

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Autor principal: Marschoff, Enrique R.
Publicado: 2013
Materias:
Alzheimer's disease
Cerebral glucose metabolism
Diabetes mellitus type 2
Hypoglycaemic drugs
Insulin resistance
Oxidative stress
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02134853_v_n_p_Dominguez
http://hdl.handle.net/20.500.12110/paper_02134853_v_n_p_Dominguez
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_02134853_v_n_p_Dominguez
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spelling paper:paper_02134853_v_n_p_Dominguez2023-06-08T15:20:50Z Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis Marschoff, Enrique R. Alzheimer's disease Cerebral glucose metabolism Diabetes mellitus type 2 Hypoglycaemic drugs Insulin resistance Oxidative stress Introduction: Epidemiological studies have demonstrated that patients with diabetes mellitus have an increased risk of developing Alzheimer disease, but the relationship between the 2 entities is not clear. Development: Both diseases exhibit similar metabolic abnormalities: disordered glucose metabolism, abnormal insulin receptor signalling and insulin resistance, oxidative stress, and structural abnormalities in proteins and β-amyloid deposits. Different hypotheses have emerged from experimental work in the last two decades. One of the most comprehensive relates the microvascular damage in diabetic polyneuritis with the central nervous system changes occurring in Alzheimer disease. Another hypothesis considers that cognitive impairment in both diabetes and Alzheimer disease is linked to a state of systemic oxidative stress. Recently, attenuation of cognitive impairment and normalisation of values in biochemical markers for oxidative stress were found in patients with Alzheimer disease and concomitant diabetes. Antidiabetic drugs may have a beneficial effect on glycolysis and its end products, and on other metabolic alterations. Conclusions: Diabetic patients are at increased risk for developing Alzheimer disease, but paradoxically, their biochemical alterations and cognitive impairment are less pronounced than in groups of dementia patients without diabetes. A deeper understanding of interactions between the pathogenic processes of both entities may lead to new therapeutic strategies that would slow or halt the progression of impairment. © 2013 Sociedad Española de Neurología. Fil:Marschoff, E.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02134853_v_n_p_Dominguez http://hdl.handle.net/20.500.12110/paper_02134853_v_n_p_Dominguez
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Alzheimer's disease
Cerebral glucose metabolism
Diabetes mellitus type 2
Hypoglycaemic drugs
Insulin resistance
Oxidative stress
spellingShingle Alzheimer's disease
Cerebral glucose metabolism
Diabetes mellitus type 2
Hypoglycaemic drugs
Insulin resistance
Oxidative stress
Marschoff, Enrique R.
Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis
topic_facet Alzheimer's disease
Cerebral glucose metabolism
Diabetes mellitus type 2
Hypoglycaemic drugs
Insulin resistance
Oxidative stress
description Introduction: Epidemiological studies have demonstrated that patients with diabetes mellitus have an increased risk of developing Alzheimer disease, but the relationship between the 2 entities is not clear. Development: Both diseases exhibit similar metabolic abnormalities: disordered glucose metabolism, abnormal insulin receptor signalling and insulin resistance, oxidative stress, and structural abnormalities in proteins and β-amyloid deposits. Different hypotheses have emerged from experimental work in the last two decades. One of the most comprehensive relates the microvascular damage in diabetic polyneuritis with the central nervous system changes occurring in Alzheimer disease. Another hypothesis considers that cognitive impairment in both diabetes and Alzheimer disease is linked to a state of systemic oxidative stress. Recently, attenuation of cognitive impairment and normalisation of values in biochemical markers for oxidative stress were found in patients with Alzheimer disease and concomitant diabetes. Antidiabetic drugs may have a beneficial effect on glycolysis and its end products, and on other metabolic alterations. Conclusions: Diabetic patients are at increased risk for developing Alzheimer disease, but paradoxically, their biochemical alterations and cognitive impairment are less pronounced than in groups of dementia patients without diabetes. A deeper understanding of interactions between the pathogenic processes of both entities may lead to new therapeutic strategies that would slow or halt the progression of impairment. © 2013 Sociedad Española de Neurología.
author Marschoff, Enrique R.
author_facet Marschoff, Enrique R.
author_sort Marschoff, Enrique R.
title Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis
title_short Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis
title_full Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis
title_fullStr Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis
title_full_unstemmed Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis
title_sort alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: associations and a hypothesis
publishDate 2013
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02134853_v_n_p_Dominguez
http://hdl.handle.net/20.500.12110/paper_02134853_v_n_p_Dominguez
work_keys_str_mv AT marschoffenriquer alzheimerdiseaseandcognitiveimpairmentassociatedwithdiabetesmellitustype2associationsandahypothesis
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