Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients
Objectives: To study the interrelationship between serum Interleukin-6 (IL-6), serum Interleukin-6 soluble Receptor (IL-6 sR), C-Reactive Protein (C-RP), plasmatic Zinc levels (PlZn) and their response in relation to Zn administered by TPN, in critical patients. Methods: 17 patients, receiving TPN a...
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2009
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02121611_v24_n3_p340_Menendez http://hdl.handle.net/20.500.12110/paper_02121611_v24_n3_p340_Menendez |
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paper:paper_02121611_v24_n3_p340_Menendez2023-06-08T15:20:44Z Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients Zeni, Susana Noemí Critically ill patients with parenteral nutrition Interleukin-6 Soluble receptor of interleukin-6, and C reactive protein Zinc C reactive protein interleukin 6 interleukin 6 receptor zinc abdominal surgery acute pancreatitis adult aged article clinical article critically ill patient diet supplementation enzyme linked immunosorbent assay female human ileus inflammation intestine cancer intestine fistula male total parenteral nutrition Adult Aged C-Reactive Protein Critical Illness Female Humans Interleukin-6 Male Middle Aged Parenteral Nutrition, Total Receptors, Interleukin-6 Zinc Fistula Objectives: To study the interrelationship between serum Interleukin-6 (IL-6), serum Interleukin-6 soluble Receptor (IL-6 sR), C-Reactive Protein (C-RP), plasmatic Zinc levels (PlZn) and their response in relation to Zn administered by TPN, in critical patients. Methods: 17 patients, receiving TPN as a consequence of acute pancreatitis (n = 4) or after a major abdominal surgery due to intestinal cancer (n = 7), intestinal fístula (n = 3), intestinal obstruction (n = 2) or intestinal íleus (n = 1) were studied. At the beginning (To) and at the end of the TPN administration (6-21days) serum IL-6 and IL-6 sR were determined by ELISA; C-RP ultrasensitive (C-RP us) by inmunoturbidimetric method; Zn was determined in TPN and in plasma by Atomic Absorption Spectrometry. Characteristics of the patients were (mean ± SD and ranges): age: 60.6 ± 11.7 (37-77) years; BMI (kg/m2): 26.0 ± 3.4 (19.9-34.0). Results: The results (mean ± standard deviation and ranges) were: Zn provided by TPN (mg/d): 6.1 ± 2.0 (range 2.8 to 10.8). Biochemical levels were, at To and Tf, respectively: (mean±SD and ranges) were at To y Tf, respectively: Zn Pl (?g/dl): 104 ± 46 (35-177); 120 ± 55 (52-229); IL-6 (pg/mL) 93 ± 74 (10-262); 117 ± 180 (7-761); IL6sR (pg/mL): 1,012 ± 322 (589-1855); 1,269 ± 451 (631-2195); C-RP us (mg/L): 71 ± 63 (2-196); 65 ± 43 (0-137). There was no correlation between variations of IL6, IL6sR, C-RP, PlZn levels and the daily amount of Zn administered in the TPN mixtures. Two patients presented a bad evolution; they received 4.2 and 5.2 md/d of Zn and showed an increase of IL6 levels, maintained high levels of IL6sR but C-RP levels decreased Conclusions: the range of 2.8 to 10.8 mg/d of Zn administered in TPN mixtures did not exacerbate the inflammatory response. Fil:Zeni, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02121611_v24_n3_p340_Menendez http://hdl.handle.net/20.500.12110/paper_02121611_v24_n3_p340_Menendez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Critically ill patients with parenteral nutrition Interleukin-6 Soluble receptor of interleukin-6, and C reactive protein Zinc C reactive protein interleukin 6 interleukin 6 receptor zinc abdominal surgery acute pancreatitis adult aged article clinical article critically ill patient diet supplementation enzyme linked immunosorbent assay female human ileus inflammation intestine cancer intestine fistula male total parenteral nutrition Adult Aged C-Reactive Protein Critical Illness Female Humans Interleukin-6 Male Middle Aged Parenteral Nutrition, Total Receptors, Interleukin-6 Zinc Fistula |
| spellingShingle |
Critically ill patients with parenteral nutrition Interleukin-6 Soluble receptor of interleukin-6, and C reactive protein Zinc C reactive protein interleukin 6 interleukin 6 receptor zinc abdominal surgery acute pancreatitis adult aged article clinical article critically ill patient diet supplementation enzyme linked immunosorbent assay female human ileus inflammation intestine cancer intestine fistula male total parenteral nutrition Adult Aged C-Reactive Protein Critical Illness Female Humans Interleukin-6 Male Middle Aged Parenteral Nutrition, Total Receptors, Interleukin-6 Zinc Fistula Zeni, Susana Noemí Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients |
| topic_facet |
Critically ill patients with parenteral nutrition Interleukin-6 Soluble receptor of interleukin-6, and C reactive protein Zinc C reactive protein interleukin 6 interleukin 6 receptor zinc abdominal surgery acute pancreatitis adult aged article clinical article critically ill patient diet supplementation enzyme linked immunosorbent assay female human ileus inflammation intestine cancer intestine fistula male total parenteral nutrition Adult Aged C-Reactive Protein Critical Illness Female Humans Interleukin-6 Male Middle Aged Parenteral Nutrition, Total Receptors, Interleukin-6 Zinc Fistula |
| description |
Objectives: To study the interrelationship between serum Interleukin-6 (IL-6), serum Interleukin-6 soluble Receptor (IL-6 sR), C-Reactive Protein (C-RP), plasmatic Zinc levels (PlZn) and their response in relation to Zn administered by TPN, in critical patients. Methods: 17 patients, receiving TPN as a consequence of acute pancreatitis (n = 4) or after a major abdominal surgery due to intestinal cancer (n = 7), intestinal fístula (n = 3), intestinal obstruction (n = 2) or intestinal íleus (n = 1) were studied. At the beginning (To) and at the end of the TPN administration (6-21days) serum IL-6 and IL-6 sR were determined by ELISA; C-RP ultrasensitive (C-RP us) by inmunoturbidimetric method; Zn was determined in TPN and in plasma by Atomic Absorption Spectrometry. Characteristics of the patients were (mean ± SD and ranges): age: 60.6 ± 11.7 (37-77) years; BMI (kg/m2): 26.0 ± 3.4 (19.9-34.0). Results: The results (mean ± standard deviation and ranges) were: Zn provided by TPN (mg/d): 6.1 ± 2.0 (range 2.8 to 10.8). Biochemical levels were, at To and Tf, respectively: (mean±SD and ranges) were at To y Tf, respectively: Zn Pl (?g/dl): 104 ± 46 (35-177); 120 ± 55 (52-229); IL-6 (pg/mL) 93 ± 74 (10-262); 117 ± 180 (7-761); IL6sR (pg/mL): 1,012 ± 322 (589-1855); 1,269 ± 451 (631-2195); C-RP us (mg/L): 71 ± 63 (2-196); 65 ± 43 (0-137). There was no correlation between variations of IL6, IL6sR, C-RP, PlZn levels and the daily amount of Zn administered in the TPN mixtures. Two patients presented a bad evolution; they received 4.2 and 5.2 md/d of Zn and showed an increase of IL6 levels, maintained high levels of IL6sR but C-RP levels decreased Conclusions: the range of 2.8 to 10.8 mg/d of Zn administered in TPN mixtures did not exacerbate the inflammatory response. |
| author |
Zeni, Susana Noemí |
| author_facet |
Zeni, Susana Noemí |
| author_sort |
Zeni, Susana Noemí |
| title |
Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients |
| title_short |
Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients |
| title_full |
Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients |
| title_fullStr |
Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients |
| title_full_unstemmed |
Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients |
| title_sort |
influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive c protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients |
| publishDate |
2009 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02121611_v24_n3_p340_Menendez http://hdl.handle.net/20.500.12110/paper_02121611_v24_n3_p340_Menendez |
| work_keys_str_mv |
AT zenisusananoemi influenceofzincadministeredbytotalparenteralnutritiononplasmaticzinclevelsonreactivecproteinonseruminterleukin6andonseruminterleukin6solublereceptorincriticalpatients |
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1768542643039502336 |