Effect of nitroxyl on the hamster retinal nitridergic pathway

There is a growing body of evidence on the role of nitric oxide (NO) in retinal physiology. Recently, interest has developed in the functional role of an alternative redox form of NO, namely nitroxyl (HNO/NO-), because it is formed by a number of diverse biochemical reactions. The aim of the present...

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Autores principales:	Saenz, Daniel Alberto, Bari, Sara Elizabeth, Chianelli, Mónica Silvia, Rosenstein, Ruth Estela
Publicado:	2007
Materias:	Nitric oxide Nitroxyl Retina amine ammonium derivative arginine cyclic GMP diethylammonium 1 (n,n diethylamino)diazen 1 ium 1,2 diolate glutathione nitric acid derivative nitric oxide nitric oxide synthase nitroxyl s nitrosothiol sodium derivative sodium trioxodinitrate thiol unclassified drug animal cell animal tissue article comparative study concentration (parameters) controlled study enzyme activity lipid peroxidation male nonhuman oxidation reduction potential priority journal regulatory mechanism retina nerve cell Syrian hamster Animals Antioxidants Arginine Cricetinae Cyclic GMP Dose-Response Relationship, Drug Glutathione Lipid Peroxidation Male Mesocricetus Nitrergic Neurons Nitric Oxide Nitric Oxide Synthase Nitrites Nitrogen Oxides Oxidative Stress Quaternary Ammonium Compounds S-Nitrosothiols Signal Transduction Visual Pathways Mesocricetus auratus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01970186_v51_n6-7_p424_Saenz http://hdl.handle.net/20.500.12110/paper_01970186_v51_n6-7_p424_Saenz
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01970186_v51_n6-7_p424_Saenz
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spelling	paper:paper_01970186_v51_n6-7_p424_Saenz2025-07-30T17:59:01Z Effect of nitroxyl on the hamster retinal nitridergic pathway Saenz, Daniel Alberto Bari, Sara Elizabeth Chianelli, Mónica Silvia Rosenstein, Ruth Estela Nitric oxide Nitroxyl Retina amine ammonium derivative arginine cyclic GMP diethylammonium 1 (n,n diethylamino)diazen 1 ium 1,2 diolate glutathione nitric acid derivative nitric oxide nitric oxide synthase nitroxyl s nitrosothiol sodium derivative sodium trioxodinitrate thiol unclassified drug animal cell animal tissue article comparative study concentration (parameters) controlled study enzyme activity lipid peroxidation male nonhuman oxidation reduction potential priority journal regulatory mechanism retina nerve cell Syrian hamster Animals Antioxidants Arginine Cricetinae Cyclic GMP Dose-Response Relationship, Drug Glutathione Lipid Peroxidation Male Mesocricetus Nitrergic Neurons Nitric Oxide Nitric Oxide Synthase Nitrites Nitrogen Oxides Oxidative Stress Quaternary Ammonium Compounds Retina S-Nitrosothiols Signal Transduction Visual Pathways Cricetinae Mesocricetus auratus There is a growing body of evidence on the role of nitric oxide (NO) in retinal physiology. Recently, interest has developed in the functional role of an alternative redox form of NO, namely nitroxyl (HNO/NO-), because it is formed by a number of diverse biochemical reactions. The aim of the present report was to comparatively analyze the effect of HNO and NO on the retinal nitridergic pathway in the golden hamster. For this purpose, sodium trioxodinitrate (Angeli's salt) and diethylammonium (Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate (DEA/NO) were used as HNO and NO releasers, respectively. Angeli's salt and DEA/NO significantly decreased nitric oxide synthase activity. In addition, Angeli's salt (but not DEA/NO) significantly decreased l-arginine uptake. DEA/NO significantly increased cGMP accumulation at low micromolar concentrations, while Angeli's salt affected this parameter with a threshold concentration of 200 μM. Although Angeli's salt and DEA/NO significantly diminished reduced glutathione and protein thiol levels in a similar way, DEA/NO was significantly more effective than AS in increasing S-nitrosothiol levels. None of these compounds increased retinal lipid peroxidation. These results suggest that HNO could regulate the hamster retinal nitridergic pathway by acting through a mechanism that only partly overlaps with that involved in NO response. © 2007 Elsevier Ltd. All rights reserved. Fil:Sáenz, D.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bari, S.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Chianelli, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rosenstein, R.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01970186_v51_n6-7_p424_Saenz http://hdl.handle.net/20.500.12110/paper_01970186_v51_n6-7_p424_Saenz
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Nitric oxide Nitroxyl Retina amine ammonium derivative arginine cyclic GMP diethylammonium 1 (n,n diethylamino)diazen 1 ium 1,2 diolate glutathione nitric acid derivative nitric oxide nitric oxide synthase nitroxyl s nitrosothiol sodium derivative sodium trioxodinitrate thiol unclassified drug animal cell animal tissue article comparative study concentration (parameters) controlled study enzyme activity lipid peroxidation male nonhuman oxidation reduction potential priority journal regulatory mechanism retina nerve cell Syrian hamster Animals Antioxidants Arginine Cricetinae Cyclic GMP Dose-Response Relationship, Drug Glutathione Lipid Peroxidation Male Mesocricetus Nitrergic Neurons Nitric Oxide Nitric Oxide Synthase Nitrites Nitrogen Oxides Oxidative Stress Quaternary Ammonium Compounds Retina S-Nitrosothiols Signal Transduction Visual Pathways Cricetinae Mesocricetus auratus
spellingShingle	Nitric oxide Nitroxyl Retina amine ammonium derivative arginine cyclic GMP diethylammonium 1 (n,n diethylamino)diazen 1 ium 1,2 diolate glutathione nitric acid derivative nitric oxide nitric oxide synthase nitroxyl s nitrosothiol sodium derivative sodium trioxodinitrate thiol unclassified drug animal cell animal tissue article comparative study concentration (parameters) controlled study enzyme activity lipid peroxidation male nonhuman oxidation reduction potential priority journal regulatory mechanism retina nerve cell Syrian hamster Animals Antioxidants Arginine Cricetinae Cyclic GMP Dose-Response Relationship, Drug Glutathione Lipid Peroxidation Male Mesocricetus Nitrergic Neurons Nitric Oxide Nitric Oxide Synthase Nitrites Nitrogen Oxides Oxidative Stress Quaternary Ammonium Compounds Retina S-Nitrosothiols Signal Transduction Visual Pathways Cricetinae Mesocricetus auratus Saenz, Daniel Alberto Bari, Sara Elizabeth Chianelli, Mónica Silvia Rosenstein, Ruth Estela Effect of nitroxyl on the hamster retinal nitridergic pathway
topic_facet	Nitric oxide Nitroxyl Retina amine ammonium derivative arginine cyclic GMP diethylammonium 1 (n,n diethylamino)diazen 1 ium 1,2 diolate glutathione nitric acid derivative nitric oxide nitric oxide synthase nitroxyl s nitrosothiol sodium derivative sodium trioxodinitrate thiol unclassified drug animal cell animal tissue article comparative study concentration (parameters) controlled study enzyme activity lipid peroxidation male nonhuman oxidation reduction potential priority journal regulatory mechanism retina nerve cell Syrian hamster Animals Antioxidants Arginine Cricetinae Cyclic GMP Dose-Response Relationship, Drug Glutathione Lipid Peroxidation Male Mesocricetus Nitrergic Neurons Nitric Oxide Nitric Oxide Synthase Nitrites Nitrogen Oxides Oxidative Stress Quaternary Ammonium Compounds Retina S-Nitrosothiols Signal Transduction Visual Pathways Cricetinae Mesocricetus auratus
description	There is a growing body of evidence on the role of nitric oxide (NO) in retinal physiology. Recently, interest has developed in the functional role of an alternative redox form of NO, namely nitroxyl (HNO/NO-), because it is formed by a number of diverse biochemical reactions. The aim of the present report was to comparatively analyze the effect of HNO and NO on the retinal nitridergic pathway in the golden hamster. For this purpose, sodium trioxodinitrate (Angeli's salt) and diethylammonium (Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate (DEA/NO) were used as HNO and NO releasers, respectively. Angeli's salt and DEA/NO significantly decreased nitric oxide synthase activity. In addition, Angeli's salt (but not DEA/NO) significantly decreased l-arginine uptake. DEA/NO significantly increased cGMP accumulation at low micromolar concentrations, while Angeli's salt affected this parameter with a threshold concentration of 200 μM. Although Angeli's salt and DEA/NO significantly diminished reduced glutathione and protein thiol levels in a similar way, DEA/NO was significantly more effective than AS in increasing S-nitrosothiol levels. None of these compounds increased retinal lipid peroxidation. These results suggest that HNO could regulate the hamster retinal nitridergic pathway by acting through a mechanism that only partly overlaps with that involved in NO response. © 2007 Elsevier Ltd. All rights reserved.
author	Saenz, Daniel Alberto Bari, Sara Elizabeth Chianelli, Mónica Silvia Rosenstein, Ruth Estela
author_facet	Saenz, Daniel Alberto Bari, Sara Elizabeth Chianelli, Mónica Silvia Rosenstein, Ruth Estela
author_sort	Saenz, Daniel Alberto
title	Effect of nitroxyl on the hamster retinal nitridergic pathway
title_short	Effect of nitroxyl on the hamster retinal nitridergic pathway
title_full	Effect of nitroxyl on the hamster retinal nitridergic pathway
title_fullStr	Effect of nitroxyl on the hamster retinal nitridergic pathway
title_full_unstemmed	Effect of nitroxyl on the hamster retinal nitridergic pathway
title_sort	effect of nitroxyl on the hamster retinal nitridergic pathway
publishDate	2007
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01970186_v51_n6-7_p424_Saenz http://hdl.handle.net/20.500.12110/paper_01970186_v51_n6-7_p424_Saenz
work_keys_str_mv	AT saenzdanielalberto effectofnitroxylonthehamsterretinalnitridergicpathway AT barisaraelizabeth effectofnitroxylonthehamsterretinalnitridergicpathway AT chianellimonicasilvia effectofnitroxylonthehamsterretinalnitridergicpathway AT rosensteinruthestela effectofnitroxylonthehamsterretinalnitridergicpathway
_version_	1840326735931899904

Effect of nitroxyl on the hamster retinal nitridergic pathway

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