Effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries

Serum prolactin (PRL) and pituitary nuclear estrogen receptors (RnE2) were determined in ovariectomized rats treated with 5 μg/kg estradiol and subjected to single or combined treatment with dopamine (DA) and tamoxifen (TAM). A significative inhibition of serum PRL was observed by DA, TAM, and DA pl...

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Detalles Bibliográficos
Publicado: 1993
Materias:
dopamine
estradiol
estrogen receptor
prolactin
tamoxifen
adenohypophysis
animal experiment
article
controlled study
drug receptor binding
female
hormone inhibition
intraperitoneal drug administration
nonhuman
ovariectomy
priority journal
prolactin blood level
rat
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0172780X_v15_n5-6_p389_Stalldecker
http://hdl.handle.net/20.500.12110/paper_0172780X_v15_n5-6_p389_Stalldecker
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_0172780X_v15_n5-6_p389_Stalldecker
record_format dspace
spelling paper:paper_0172780X_v15_n5-6_p389_Stalldecker2023-06-08T15:18:45Z Effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries dopamine estradiol estrogen receptor prolactin tamoxifen adenohypophysis animal experiment article controlled study drug receptor binding female hormone inhibition intraperitoneal drug administration nonhuman ovariectomy priority journal prolactin blood level rat Serum prolactin (PRL) and pituitary nuclear estrogen receptors (RnE2) were determined in ovariectomized rats treated with 5 μg/kg estradiol and subjected to single or combined treatment with dopamine (DA) and tamoxifen (TAM). A significative inhibition of serum PRL was observed by DA, TAM, and DA plus TAM treatment. TAM, as well as DA, increased RnE2, but DA reduced the TAM effect when they were administered together. This observation suggests competition for a common binding site on the RnE2 between TAM and DA or by an unknown ligand produced after treatment with DA. The lack of an additive effect on PRL inhibition in the combined treatment indicates that both agents share at least one common inhibitory mechanism for PRL, behaving as antagonists of estrogen action at the receptor level. 1993 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0172780X_v15_n5-6_p389_Stalldecker http://hdl.handle.net/20.500.12110/paper_0172780X_v15_n5-6_p389_Stalldecker
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic dopamine
estradiol
estrogen receptor
prolactin
tamoxifen
adenohypophysis
animal experiment
article
controlled study
drug receptor binding
female
hormone inhibition
intraperitoneal drug administration
nonhuman
ovariectomy
priority journal
prolactin blood level
rat
spellingShingle dopamine
estradiol
estrogen receptor
prolactin
tamoxifen
adenohypophysis
animal experiment
article
controlled study
drug receptor binding
female
hormone inhibition
intraperitoneal drug administration
nonhuman
ovariectomy
priority journal
prolactin blood level
rat
Effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries
topic_facet dopamine
estradiol
estrogen receptor
prolactin
tamoxifen
adenohypophysis
animal experiment
article
controlled study
drug receptor binding
female
hormone inhibition
intraperitoneal drug administration
nonhuman
ovariectomy
priority journal
prolactin blood level
rat
description Serum prolactin (PRL) and pituitary nuclear estrogen receptors (RnE2) were determined in ovariectomized rats treated with 5 μg/kg estradiol and subjected to single or combined treatment with dopamine (DA) and tamoxifen (TAM). A significative inhibition of serum PRL was observed by DA, TAM, and DA plus TAM treatment. TAM, as well as DA, increased RnE2, but DA reduced the TAM effect when they were administered together. This observation suggests competition for a common binding site on the RnE2 between TAM and DA or by an unknown ligand produced after treatment with DA. The lack of an additive effect on PRL inhibition in the combined treatment indicates that both agents share at least one common inhibitory mechanism for PRL, behaving as antagonists of estrogen action at the receptor level.
title Effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries
title_short Effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries
title_full Effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries
title_fullStr Effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries
title_full_unstemmed Effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries
title_sort effects of dopamine and tamoxifen on serum prolactin and nuclear estrogen receptors in rat anterior pituitaries
publishDate 1993
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0172780X_v15_n5-6_p389_Stalldecker
http://hdl.handle.net/20.500.12110/paper_0172780X_v15_n5-6_p389_Stalldecker
_version_ 1768544637351362560

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