Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices

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The structure of scleroglucan gel matrices was characterized by dynamic rheological studies. The results were compared with the release kinetics of theophylline in analogous samples using a Franz diffusion cell, fitting the drug release data with a semi-empirical power law. Dynamic rheology gave inf...

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Autores principales:	Rojas, Ana María Luisa, Daraio, Marta Edit, Bernik, Delia Leticia
Publicado:	2003
Materias:	Drug release Dynamic rheology Hydrophilic matrices Scleroglucan Elasticity Gels Reaction kinetics Rheology Viscosity Franz diffusion cells Controlled drug delivery scleroglucan theophylline article drug release drug structure elasticity flow kinetics gel priority journal viscosity
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01683659_v90_n3_p355_Francois http://hdl.handle.net/20.500.12110/paper_01683659_v90_n3_p355_Francois
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01683659_v90_n3_p355_Francois
record_format	dspace
spelling	paper:paper_01683659_v90_n3_p355_Francois2023-06-08T15:17:45Z Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices Rojas, Ana María Luisa Daraio, Marta Edit Bernik, Delia Leticia Drug release Dynamic rheology Hydrophilic matrices Scleroglucan Elasticity Gels Reaction kinetics Rheology Viscosity Franz diffusion cells Controlled drug delivery scleroglucan theophylline article drug release drug structure elasticity flow kinetics gel priority journal viscosity The structure of scleroglucan gel matrices was characterized by dynamic rheological studies. The results were compared with the release kinetics of theophylline in analogous samples using a Franz diffusion cell, fitting the drug release data with a semi-empirical power law. Dynamic rheology gave information about the viscous and elastic components (loss and storage moduli, respectively) of the gel which could influence the drug-release profiles. Scleroglucan gels showed two structural transitions within the gel regime that coincided with changes in the release pattern. It was found that the introduction of 0.4% (w/w) of theophylline decreased the loss and storage moduli in the 2% (w/w) scleroglucan gels by 50%. The influence of the same wt.% theophylline in other gels was strongly dependent on the gel concentration. These results demonstrated the value of rheological studies to detect matrix structural changes produced by the inclusion of drugs which may modify the drug-release profile. © 2003 Elsevier B.V. All rights reserved. Fil:Rojas, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Daraio, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bernik, D.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2003 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01683659_v90_n3_p355_Francois http://hdl.handle.net/20.500.12110/paper_01683659_v90_n3_p355_Francois
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Drug release Dynamic rheology Hydrophilic matrices Scleroglucan Elasticity Gels Reaction kinetics Rheology Viscosity Franz diffusion cells Controlled drug delivery scleroglucan theophylline article drug release drug structure elasticity flow kinetics gel priority journal viscosity
spellingShingle	Drug release Dynamic rheology Hydrophilic matrices Scleroglucan Elasticity Gels Reaction kinetics Rheology Viscosity Franz diffusion cells Controlled drug delivery scleroglucan theophylline article drug release drug structure elasticity flow kinetics gel priority journal viscosity Rojas, Ana María Luisa Daraio, Marta Edit Bernik, Delia Leticia Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices
topic_facet	Drug release Dynamic rheology Hydrophilic matrices Scleroglucan Elasticity Gels Reaction kinetics Rheology Viscosity Franz diffusion cells Controlled drug delivery scleroglucan theophylline article drug release drug structure elasticity flow kinetics gel priority journal viscosity
description	The structure of scleroglucan gel matrices was characterized by dynamic rheological studies. The results were compared with the release kinetics of theophylline in analogous samples using a Franz diffusion cell, fitting the drug release data with a semi-empirical power law. Dynamic rheology gave information about the viscous and elastic components (loss and storage moduli, respectively) of the gel which could influence the drug-release profiles. Scleroglucan gels showed two structural transitions within the gel regime that coincided with changes in the release pattern. It was found that the introduction of 0.4% (w/w) of theophylline decreased the loss and storage moduli in the 2% (w/w) scleroglucan gels by 50%. The influence of the same wt.% theophylline in other gels was strongly dependent on the gel concentration. These results demonstrated the value of rheological studies to detect matrix structural changes produced by the inclusion of drugs which may modify the drug-release profile. © 2003 Elsevier B.V. All rights reserved.
author	Rojas, Ana María Luisa Daraio, Marta Edit Bernik, Delia Leticia
author_facet	Rojas, Ana María Luisa Daraio, Marta Edit Bernik, Delia Leticia
author_sort	Rojas, Ana María Luisa
title	Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices
title_short	Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices
title_full	Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices
title_fullStr	Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices
title_full_unstemmed	Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices
title_sort	dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices
publishDate	2003
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01683659_v90_n3_p355_Francois http://hdl.handle.net/20.500.12110/paper_01683659_v90_n3_p355_Francois
work_keys_str_mv	AT rojasanamarialuisa dynamicrheologicalmeasurementsanddrugreleasekineticsinswollenscleroglucanmatrices AT daraiomartaedit dynamicrheologicalmeasurementsanddrugreleasekineticsinswollenscleroglucanmatrices AT bernikdelialeticia dynamicrheologicalmeasurementsanddrugreleasekineticsinswollenscleroglucanmatrices
_version_	1768544546980888576

Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices

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