Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats
Isolated hepatocytes from rats with experimental diabetes exhibit increased content of cytochrome P-450 and cyclic AMP and normal activities of the regulatory enzymes δ-aminolevulinic acid synthase and ferrochelatase. The inducing effect exerted by phenobarbital on cytochrome P-450, δ-aminolevulinic...
Guardado en:
| Autores principales: | , , , |
|---|---|
| Publicado: |
1985
|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674889_v847_n2_p191_Canepa http://hdl.handle.net/20.500.12110/paper_01674889_v847_n2_p191_Canepa |
| Aporte de: |
| id |
paper:paper_01674889_v847_n2_p191_Canepa |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_01674889_v847_n2_p191_Canepa2023-06-08T15:16:31Z Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats Cánepa, Eduardo Tomás Galvagno, Miguel Angel Llambías, Elena Blanca Cecilia Grinstein, Moisés (Diabetic rat hepatocyte) cyclic AMP Cytochrome P-450 Enzyme induction Ferrochelatase δ-Aminolevulinic acid synthase 5 aminolevulinate synthase cyclic amp cytochrome p450 ferrochelatase heme animal model biosynthesis diabetes mellitus endocrine system etiology experimental diabetes mellitus liver liver cell nonhuman priority journal rat 5-Aminolevulinate Synthetase Animals Bucladesine Cyclic AMP Cytochrome P-450 Enzyme System Diabetes Mellitus, Experimental Ferrochelatase Glucose Heme Homeostasis Kinetics Liver Male Phenobarbital Rats Rats, Inbred Strains Reference Values Isolated hepatocytes from rats with experimental diabetes exhibit increased content of cytochrome P-450 and cyclic AMP and normal activities of the regulatory enzymes δ-aminolevulinic acid synthase and ferrochelatase. The inducing effect exerted by phenobarbital on cytochrome P-450, δ-aminolevulinic acid synthase and ferrochelatase biosynthesis and cyclic AMP content in diabetic hepatic cells is markedly greater than that observed in normal hepatocytes. This stimulatory response is neither enhanced by added dibutyryl cyclic AMP nor repressed by glucose. The present results suggest that the heme pathway of diabetic hepatocytes is more susceptible to porphyrinogenic factors. © 1985. Fil:Cánepa, E.T. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Galvagno, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Llambías, E.B.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Grinstein, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1985 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674889_v847_n2_p191_Canepa http://hdl.handle.net/20.500.12110/paper_01674889_v847_n2_p191_Canepa |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
(Diabetic rat hepatocyte) cyclic AMP Cytochrome P-450 Enzyme induction Ferrochelatase δ-Aminolevulinic acid synthase 5 aminolevulinate synthase cyclic amp cytochrome p450 ferrochelatase heme animal model biosynthesis diabetes mellitus endocrine system etiology experimental diabetes mellitus liver liver cell nonhuman priority journal rat 5-Aminolevulinate Synthetase Animals Bucladesine Cyclic AMP Cytochrome P-450 Enzyme System Diabetes Mellitus, Experimental Ferrochelatase Glucose Heme Homeostasis Kinetics Liver Male Phenobarbital Rats Rats, Inbred Strains Reference Values |
| spellingShingle |
(Diabetic rat hepatocyte) cyclic AMP Cytochrome P-450 Enzyme induction Ferrochelatase δ-Aminolevulinic acid synthase 5 aminolevulinate synthase cyclic amp cytochrome p450 ferrochelatase heme animal model biosynthesis diabetes mellitus endocrine system etiology experimental diabetes mellitus liver liver cell nonhuman priority journal rat 5-Aminolevulinate Synthetase Animals Bucladesine Cyclic AMP Cytochrome P-450 Enzyme System Diabetes Mellitus, Experimental Ferrochelatase Glucose Heme Homeostasis Kinetics Liver Male Phenobarbital Rats Rats, Inbred Strains Reference Values Cánepa, Eduardo Tomás Galvagno, Miguel Angel Llambías, Elena Blanca Cecilia Grinstein, Moisés Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats |
| topic_facet |
(Diabetic rat hepatocyte) cyclic AMP Cytochrome P-450 Enzyme induction Ferrochelatase δ-Aminolevulinic acid synthase 5 aminolevulinate synthase cyclic amp cytochrome p450 ferrochelatase heme animal model biosynthesis diabetes mellitus endocrine system etiology experimental diabetes mellitus liver liver cell nonhuman priority journal rat 5-Aminolevulinate Synthetase Animals Bucladesine Cyclic AMP Cytochrome P-450 Enzyme System Diabetes Mellitus, Experimental Ferrochelatase Glucose Heme Homeostasis Kinetics Liver Male Phenobarbital Rats Rats, Inbred Strains Reference Values |
| description |
Isolated hepatocytes from rats with experimental diabetes exhibit increased content of cytochrome P-450 and cyclic AMP and normal activities of the regulatory enzymes δ-aminolevulinic acid synthase and ferrochelatase. The inducing effect exerted by phenobarbital on cytochrome P-450, δ-aminolevulinic acid synthase and ferrochelatase biosynthesis and cyclic AMP content in diabetic hepatic cells is markedly greater than that observed in normal hepatocytes. This stimulatory response is neither enhanced by added dibutyryl cyclic AMP nor repressed by glucose. The present results suggest that the heme pathway of diabetic hepatocytes is more susceptible to porphyrinogenic factors. © 1985. |
| author |
Cánepa, Eduardo Tomás Galvagno, Miguel Angel Llambías, Elena Blanca Cecilia Grinstein, Moisés |
| author_facet |
Cánepa, Eduardo Tomás Galvagno, Miguel Angel Llambías, Elena Blanca Cecilia Grinstein, Moisés |
| author_sort |
Cánepa, Eduardo Tomás |
| title |
Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats |
| title_short |
Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats |
| title_full |
Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats |
| title_fullStr |
Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats |
| title_full_unstemmed |
Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats |
| title_sort |
studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats |
| publishDate |
1985 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674889_v847_n2_p191_Canepa http://hdl.handle.net/20.500.12110/paper_01674889_v847_n2_p191_Canepa |
| work_keys_str_mv |
AT canepaeduardotomas studiesonregulatorymechanismsofhemebiosynthesisinhepatocytesfromexperimentaldiabeticrats AT galvagnomiguelangel studiesonregulatorymechanismsofhemebiosynthesisinhepatocytesfromexperimentaldiabeticrats AT llambiaselenablancacecilia studiesonregulatorymechanismsofhemebiosynthesisinhepatocytesfromexperimentaldiabeticrats AT grinsteinmoises studiesonregulatorymechanismsofhemebiosynthesisinhepatocytesfromexperimentaldiabeticrats |
| _version_ |
1768541605377081344 |