Protein synthesis in polyamine-deficient bacteria during amino-acid starvation
Amino-acid starvation in polyamine-auxotrophic bacteria grown in the presence of putrescine provokes a marked inhibition of protein synthesis. This inhibition is almost completely relieved in polyamine-depleted cells. The differential behaviour of bacterial protein synthesis depending on the endogen...
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1988
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674781_v949_n1_p65_Nastri http://hdl.handle.net/20.500.12110/paper_01674781_v949_n1_p65_Nastri |
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paper:paper_01674781_v949_n1_p65_Nastri2023-06-08T15:16:24Z Protein synthesis in polyamine-deficient bacteria during amino-acid starvation Nastri, Horacio Gabriel Algranati, Israel David (E. coli) Amino acid starvation Polyamide auxotrophy Translation amino acid bacterial protein polyamine putrescine article biosynthesis drug effect Escherichia coli genetics kinetics metabolism molecular weight transport at the cellular level Amino Acids Bacterial Proteins Biological Transport Escherichia coli Kinetics Molecular Weight Polyamines Putrescine Support, Non-U.S. Gov't Amino-acid starvation in polyamine-auxotrophic bacteria grown in the presence of putrescine provokes a marked inhibition of protein synthesis. This inhibition is almost completely relieved in polyamine-depleted cells. The differential behaviour of bacterial protein synthesis depending on the endogenous levels of polyamines is not due to a change in the uptake of amino acids used to measure protein synthesis, nor to the decreased growth rate of polyamine-depleted cells. During leucine starvation, cells grown with putrescine synthesized a somewhat lower amount of high-molecular-weight proteins than polyamine-depleted bacteria. In addition, cells with normal endogenous levels of polyamines accumulated significant amounts of 62 and 41 kDa polypeptides as well as several low-molecular-weight peptides. © 1988. Fil:Nastri, H.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Algranati, I.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1988 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674781_v949_n1_p65_Nastri http://hdl.handle.net/20.500.12110/paper_01674781_v949_n1_p65_Nastri |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
(E. coli) Amino acid starvation Polyamide auxotrophy Translation amino acid bacterial protein polyamine putrescine article biosynthesis drug effect Escherichia coli genetics kinetics metabolism molecular weight transport at the cellular level Amino Acids Bacterial Proteins Biological Transport Escherichia coli Kinetics Molecular Weight Polyamines Putrescine Support, Non-U.S. Gov't |
| spellingShingle |
(E. coli) Amino acid starvation Polyamide auxotrophy Translation amino acid bacterial protein polyamine putrescine article biosynthesis drug effect Escherichia coli genetics kinetics metabolism molecular weight transport at the cellular level Amino Acids Bacterial Proteins Biological Transport Escherichia coli Kinetics Molecular Weight Polyamines Putrescine Support, Non-U.S. Gov't Nastri, Horacio Gabriel Algranati, Israel David Protein synthesis in polyamine-deficient bacteria during amino-acid starvation |
| topic_facet |
(E. coli) Amino acid starvation Polyamide auxotrophy Translation amino acid bacterial protein polyamine putrescine article biosynthesis drug effect Escherichia coli genetics kinetics metabolism molecular weight transport at the cellular level Amino Acids Bacterial Proteins Biological Transport Escherichia coli Kinetics Molecular Weight Polyamines Putrescine Support, Non-U.S. Gov't |
| description |
Amino-acid starvation in polyamine-auxotrophic bacteria grown in the presence of putrescine provokes a marked inhibition of protein synthesis. This inhibition is almost completely relieved in polyamine-depleted cells. The differential behaviour of bacterial protein synthesis depending on the endogenous levels of polyamines is not due to a change in the uptake of amino acids used to measure protein synthesis, nor to the decreased growth rate of polyamine-depleted cells. During leucine starvation, cells grown with putrescine synthesized a somewhat lower amount of high-molecular-weight proteins than polyamine-depleted bacteria. In addition, cells with normal endogenous levels of polyamines accumulated significant amounts of 62 and 41 kDa polypeptides as well as several low-molecular-weight peptides. © 1988. |
| author |
Nastri, Horacio Gabriel Algranati, Israel David |
| author_facet |
Nastri, Horacio Gabriel Algranati, Israel David |
| author_sort |
Nastri, Horacio Gabriel |
| title |
Protein synthesis in polyamine-deficient bacteria during amino-acid starvation |
| title_short |
Protein synthesis in polyamine-deficient bacteria during amino-acid starvation |
| title_full |
Protein synthesis in polyamine-deficient bacteria during amino-acid starvation |
| title_fullStr |
Protein synthesis in polyamine-deficient bacteria during amino-acid starvation |
| title_full_unstemmed |
Protein synthesis in polyamine-deficient bacteria during amino-acid starvation |
| title_sort |
protein synthesis in polyamine-deficient bacteria during amino-acid starvation |
| publishDate |
1988 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674781_v949_n1_p65_Nastri http://hdl.handle.net/20.500.12110/paper_01674781_v949_n1_p65_Nastri |
| work_keys_str_mv |
AT nastrihoraciogabriel proteinsynthesisinpolyaminedeficientbacteriaduringaminoacidstarvation AT algranatiisraeldavid proteinsynthesisinpolyaminedeficientbacteriaduringaminoacidstarvation |
| _version_ |
1768541886759305216 |