The effect of buffered calcium diffusion on neurotransmitter release

Calcium plays a major role in inter-neuron communication. It has recently been observed that the scaling relationship between extracellular calcium concentration and postsynaptic response is different depending on the channel through which calcium enters the presynaptic neuron. Experiments suggest t...

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Detalles Bibliográficos
Autores principales:	Ponce Dawson, Silvina, Uchitel, Osvaldo Daniel
Publicado:	2002
Materias:	Calcium Neurotransmitter Rapid buffering approximation Biological membranes Diffusion Muscle Positive ions Neurotransmitters Neurology
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01672789_v168-169_n_p356_PonceDawson http://hdl.handle.net/20.500.12110/paper_01672789_v168-169_n_p356_PonceDawson
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01672789_v168-169_n_p356_PonceDawson
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spelling	paper:paper_01672789_v168-169_n_p356_PonceDawson2023-06-08T15:16:17Z The effect of buffered calcium diffusion on neurotransmitter release Ponce Dawson, Silvina Uchitel, Osvaldo Daniel Calcium Neurotransmitter Rapid buffering approximation Biological membranes Calcium Diffusion Muscle Positive ions Neurotransmitters Neurology Calcium plays a major role in inter-neuron communication. It has recently been observed that the scaling relationship between extracellular calcium concentration and postsynaptic response is different depending on the channel through which calcium enters the presynaptic neuron. Experiments suggest that the two types of calcium channels probed in this regard are at different mean distances from the neurotransmitter-containing vesicles. In this work we investigate whether the effect of calcium buffers along the path from the channel to the vesicle sensor can be responsible for the differences observed. Our results show that buffers cannot account for this change. This study also allows us to probe the limitations of the rapid buffering approximation in the presence of strong and localized sources. © 2002 Elsevier Science B.V. All rights reserved. Fil:Ponce Dawson, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Uchitel, O.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2002 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01672789_v168-169_n_p356_PonceDawson http://hdl.handle.net/20.500.12110/paper_01672789_v168-169_n_p356_PonceDawson
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Calcium Neurotransmitter Rapid buffering approximation Biological membranes Calcium Diffusion Muscle Positive ions Neurotransmitters Neurology
spellingShingle	Calcium Neurotransmitter Rapid buffering approximation Biological membranes Calcium Diffusion Muscle Positive ions Neurotransmitters Neurology Ponce Dawson, Silvina Uchitel, Osvaldo Daniel The effect of buffered calcium diffusion on neurotransmitter release
topic_facet	Calcium Neurotransmitter Rapid buffering approximation Biological membranes Calcium Diffusion Muscle Positive ions Neurotransmitters Neurology
description	Calcium plays a major role in inter-neuron communication. It has recently been observed that the scaling relationship between extracellular calcium concentration and postsynaptic response is different depending on the channel through which calcium enters the presynaptic neuron. Experiments suggest that the two types of calcium channels probed in this regard are at different mean distances from the neurotransmitter-containing vesicles. In this work we investigate whether the effect of calcium buffers along the path from the channel to the vesicle sensor can be responsible for the differences observed. Our results show that buffers cannot account for this change. This study also allows us to probe the limitations of the rapid buffering approximation in the presence of strong and localized sources. © 2002 Elsevier Science B.V. All rights reserved.
author	Ponce Dawson, Silvina Uchitel, Osvaldo Daniel
author_facet	Ponce Dawson, Silvina Uchitel, Osvaldo Daniel
author_sort	Ponce Dawson, Silvina
title	The effect of buffered calcium diffusion on neurotransmitter release
title_short	The effect of buffered calcium diffusion on neurotransmitter release
title_full	The effect of buffered calcium diffusion on neurotransmitter release
title_fullStr	The effect of buffered calcium diffusion on neurotransmitter release
title_full_unstemmed	The effect of buffered calcium diffusion on neurotransmitter release
title_sort	effect of buffered calcium diffusion on neurotransmitter release
publishDate	2002
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01672789_v168-169_n_p356_PonceDawson http://hdl.handle.net/20.500.12110/paper_01672789_v168-169_n_p356_PonceDawson
work_keys_str_mv	AT poncedawsonsilvina theeffectofbufferedcalciumdiffusiononneurotransmitterrelease AT uchitelosvaldodaniel theeffectofbufferedcalciumdiffusiononneurotransmitterrelease AT poncedawsonsilvina effectofbufferedcalciumdiffusiononneurotransmitterrelease AT uchitelosvaldodaniel effectofbufferedcalciumdiffusiononneurotransmitterrelease
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The effect of buffered calcium diffusion on neurotransmitter release

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