Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production

We focus on how the IL-1 system, T-helper1 (Th1) or Th2 cytokines and glucocorticoids, converge to give a unified physiological response. Glucocorticoids inhibit IL-1 and IL-1 receptor antagonist (IL-1ra) expression, Th1 cytokines stimulate both and Th2 cytokines stimulate IL-1ra and inhibit IL-1. T...

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Autores principales:	Kovalovsky, Damián, Refojo, Damián
Publicado:	2000
Materias:	Cytokines Glucocorticoids IL-1 IL-1ra Th1 Th2 cytokine gamma interferon glucocorticoid glucocorticoid receptor hydrocortisone immunoglobulin enhancer binding protein interleukin 1 interleukin 1 receptor blocking agent interleukin 10 interleukin 13 interleukin 2 interleukin 4 interleukin 5 lipopolysaccharide lymphotoxin STAT protein transcription factor transcription factor AP 1 transcription factor GATA 3 transforming growth factor beta article genetic transcription hormonal regulation human hypothalamus hypophysis adrenal system immune response immune system inflammation priority journal Animals Humans Hypothalamo-Hypophyseal System Interleukin 1 Receptor Antagonist Protein Interleukin-1 Pituitary-Adrenal System Sialoglycoproteins Signal Transduction Th1 Cells Th2 Cells Transcription, Genetic
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01655728_v109_n1_p23_Kovalovsky http://hdl.handle.net/20.500.12110/paper_01655728_v109_n1_p23_Kovalovsky
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01655728_v109_n1_p23_Kovalovsky
record_format	dspace
spelling	paper:paper_01655728_v109_n1_p23_Kovalovsky2025-07-30T17:53:50Z Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production Kovalovsky, Damián Refojo, Damián Cytokines Glucocorticoids IL-1 IL-1ra Th1 Th2 cytokine gamma interferon glucocorticoid glucocorticoid receptor hydrocortisone immunoglobulin enhancer binding protein interleukin 1 interleukin 1 receptor blocking agent interleukin 10 interleukin 13 interleukin 2 interleukin 4 interleukin 5 lipopolysaccharide lymphotoxin STAT protein transcription factor transcription factor AP 1 transcription factor GATA 3 transforming growth factor beta article genetic transcription hormonal regulation human hypothalamus hypophysis adrenal system immune response immune system inflammation priority journal Animals Glucocorticoids Humans Hypothalamo-Hypophyseal System Interleukin 1 Receptor Antagonist Protein Interleukin-1 Pituitary-Adrenal System Sialoglycoproteins Signal Transduction Th1 Cells Th2 Cells Transcription, Genetic We focus on how the IL-1 system, T-helper1 (Th1) or Th2 cytokines and glucocorticoids, converge to give a unified physiological response. Glucocorticoids inhibit IL-1 and IL-1 receptor antagonist (IL-1ra) expression, Th1 cytokines stimulate both and Th2 cytokines stimulate IL-1ra and inhibit IL-1. Thus, during the Th1 response there is a window for IL-1 inflammatory activity, absent during the Th2 response. We also study the interactions among glucocorticoid and cytokine transcriptional activity. Glucocorticoids inhibit cytokine-induced transcription factors (NFkB, AP1) and cytokines enhance glucocorticoid receptor (GR) transcriptional activity, thus reciprocally fine tuning immunological control mechanisms. (C) 2000 Elsevier Science B.V. Fil:Kovalovsky, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Refojo, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2000 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01655728_v109_n1_p23_Kovalovsky http://hdl.handle.net/20.500.12110/paper_01655728_v109_n1_p23_Kovalovsky
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Cytokines Glucocorticoids IL-1 IL-1ra Th1 Th2 cytokine gamma interferon glucocorticoid glucocorticoid receptor hydrocortisone immunoglobulin enhancer binding protein interleukin 1 interleukin 1 receptor blocking agent interleukin 10 interleukin 13 interleukin 2 interleukin 4 interleukin 5 lipopolysaccharide lymphotoxin STAT protein transcription factor transcription factor AP 1 transcription factor GATA 3 transforming growth factor beta article genetic transcription hormonal regulation human hypothalamus hypophysis adrenal system immune response immune system inflammation priority journal Animals Glucocorticoids Humans Hypothalamo-Hypophyseal System Interleukin 1 Receptor Antagonist Protein Interleukin-1 Pituitary-Adrenal System Sialoglycoproteins Signal Transduction Th1 Cells Th2 Cells Transcription, Genetic
spellingShingle	Cytokines Glucocorticoids IL-1 IL-1ra Th1 Th2 cytokine gamma interferon glucocorticoid glucocorticoid receptor hydrocortisone immunoglobulin enhancer binding protein interleukin 1 interleukin 1 receptor blocking agent interleukin 10 interleukin 13 interleukin 2 interleukin 4 interleukin 5 lipopolysaccharide lymphotoxin STAT protein transcription factor transcription factor AP 1 transcription factor GATA 3 transforming growth factor beta article genetic transcription hormonal regulation human hypothalamus hypophysis adrenal system immune response immune system inflammation priority journal Animals Glucocorticoids Humans Hypothalamo-Hypophyseal System Interleukin 1 Receptor Antagonist Protein Interleukin-1 Pituitary-Adrenal System Sialoglycoproteins Signal Transduction Th1 Cells Th2 Cells Transcription, Genetic Kovalovsky, Damián Refojo, Damián Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production
topic_facet	Cytokines Glucocorticoids IL-1 IL-1ra Th1 Th2 cytokine gamma interferon glucocorticoid glucocorticoid receptor hydrocortisone immunoglobulin enhancer binding protein interleukin 1 interleukin 1 receptor blocking agent interleukin 10 interleukin 13 interleukin 2 interleukin 4 interleukin 5 lipopolysaccharide lymphotoxin STAT protein transcription factor transcription factor AP 1 transcription factor GATA 3 transforming growth factor beta article genetic transcription hormonal regulation human hypothalamus hypophysis adrenal system immune response immune system inflammation priority journal Animals Glucocorticoids Humans Hypothalamo-Hypophyseal System Interleukin 1 Receptor Antagonist Protein Interleukin-1 Pituitary-Adrenal System Sialoglycoproteins Signal Transduction Th1 Cells Th2 Cells Transcription, Genetic
description	We focus on how the IL-1 system, T-helper1 (Th1) or Th2 cytokines and glucocorticoids, converge to give a unified physiological response. Glucocorticoids inhibit IL-1 and IL-1 receptor antagonist (IL-1ra) expression, Th1 cytokines stimulate both and Th2 cytokines stimulate IL-1ra and inhibit IL-1. Thus, during the Th1 response there is a window for IL-1 inflammatory activity, absent during the Th2 response. We also study the interactions among glucocorticoid and cytokine transcriptional activity. Glucocorticoids inhibit cytokine-induced transcription factors (NFkB, AP1) and cytokines enhance glucocorticoid receptor (GR) transcriptional activity, thus reciprocally fine tuning immunological control mechanisms. (C) 2000 Elsevier Science B.V.
author	Kovalovsky, Damián Refojo, Damián
author_facet	Kovalovsky, Damián Refojo, Damián
author_sort	Kovalovsky, Damián
title	Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production
title_short	Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production
title_full	Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production
title_fullStr	Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production
title_full_unstemmed	Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production
title_sort	molecular mechanisms and th1/th2 pathways in corticosteroid regulation of cytokine production
publishDate	2000
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01655728_v109_n1_p23_Kovalovsky http://hdl.handle.net/20.500.12110/paper_01655728_v109_n1_p23_Kovalovsky
work_keys_str_mv	AT kovalovskydamian molecularmechanismsandth1th2pathwaysincorticosteroidregulationofcytokineproduction AT refojodamian molecularmechanismsandth1th2pathwaysincorticosteroidregulationofcytokineproduction
_version_	1840326389787525120

Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production

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