Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin
Receptors for insulin and insulin-like growth factor-1 (IGF-1) have been demonstrated on activated T-lymphocytes. The question is whether receptors for insulin or IGF-1 have any function in these cells. In this study we demonstrate that the concentration of IGF-1 in commercial samples of fetal calf...
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1989
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01652478_v20_n1_p5_Roldan http://hdl.handle.net/20.500.12110/paper_01652478_v20_n1_p5_Roldan |
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paper:paper_01652478_v20_n1_p5_Roldan2023-06-08T15:14:50Z Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin Fetal calf serum Human peripheral blood mononuclear cells Insulin-like growth factor-1 (IGF-1) Mitogenic response growth factor insulin mitogenic agent phytohemagglutinin cell culture human human cell normal human peripheral lymphocyte priority journal t lymphocyte Animal Antibodies Cattle Cell Division Fetal Blood Human Insulin-Like Growth Factor I Lymphocyte Activation Phytohemagglutinins Receptors, Cell Surface Receptors, Somatomedin Recombinant Proteins Somatomedins Stimulation, Chemical Support, Non-U.S. Gov't T-Lymphocytes Receptors for insulin and insulin-like growth factor-1 (IGF-1) have been demonstrated on activated T-lymphocytes. The question is whether receptors for insulin or IGF-1 have any function in these cells. In this study we demonstrate that the concentration of IGF-1 in commercial samples of fetal calf serum is about 70 times that of insuli. Moreover, antibodies of IGF-1 reduce responses of human peripheral blood mononuclear cells to PHA by about 50% whereas antibodies to insulin have no demonstrable effect. These observations suggest that binding of IGF-1 to specific receptors contributes to the proliferative responses of activated T-lymphocytes. © 1989. 1989 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01652478_v20_n1_p5_Roldan http://hdl.handle.net/20.500.12110/paper_01652478_v20_n1_p5_Roldan |
| institution |
Universidad de Buenos Aires |
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I-28 |
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R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Fetal calf serum Human peripheral blood mononuclear cells Insulin-like growth factor-1 (IGF-1) Mitogenic response growth factor insulin mitogenic agent phytohemagglutinin cell culture human human cell normal human peripheral lymphocyte priority journal t lymphocyte Animal Antibodies Cattle Cell Division Fetal Blood Human Insulin-Like Growth Factor I Lymphocyte Activation Phytohemagglutinins Receptors, Cell Surface Receptors, Somatomedin Recombinant Proteins Somatomedins Stimulation, Chemical Support, Non-U.S. Gov't T-Lymphocytes |
| spellingShingle |
Fetal calf serum Human peripheral blood mononuclear cells Insulin-like growth factor-1 (IGF-1) Mitogenic response growth factor insulin mitogenic agent phytohemagglutinin cell culture human human cell normal human peripheral lymphocyte priority journal t lymphocyte Animal Antibodies Cattle Cell Division Fetal Blood Human Insulin-Like Growth Factor I Lymphocyte Activation Phytohemagglutinins Receptors, Cell Surface Receptors, Somatomedin Recombinant Proteins Somatomedins Stimulation, Chemical Support, Non-U.S. Gov't T-Lymphocytes Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin |
| topic_facet |
Fetal calf serum Human peripheral blood mononuclear cells Insulin-like growth factor-1 (IGF-1) Mitogenic response growth factor insulin mitogenic agent phytohemagglutinin cell culture human human cell normal human peripheral lymphocyte priority journal t lymphocyte Animal Antibodies Cattle Cell Division Fetal Blood Human Insulin-Like Growth Factor I Lymphocyte Activation Phytohemagglutinins Receptors, Cell Surface Receptors, Somatomedin Recombinant Proteins Somatomedins Stimulation, Chemical Support, Non-U.S. Gov't T-Lymphocytes |
| description |
Receptors for insulin and insulin-like growth factor-1 (IGF-1) have been demonstrated on activated T-lymphocytes. The question is whether receptors for insulin or IGF-1 have any function in these cells. In this study we demonstrate that the concentration of IGF-1 in commercial samples of fetal calf serum is about 70 times that of insuli. Moreover, antibodies of IGF-1 reduce responses of human peripheral blood mononuclear cells to PHA by about 50% whereas antibodies to insulin have no demonstrable effect. These observations suggest that binding of IGF-1 to specific receptors contributes to the proliferative responses of activated T-lymphocytes. © 1989. |
| title |
Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin |
| title_short |
Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin |
| title_full |
Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin |
| title_fullStr |
Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin |
| title_full_unstemmed |
Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin |
| title_sort |
insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin |
| publishDate |
1989 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01652478_v20_n1_p5_Roldan http://hdl.handle.net/20.500.12110/paper_01652478_v20_n1_p5_Roldan |
| _version_ |
1768545921135542272 |