Antifungal terpenoids from Hyalis argentea var. latisquama

A detailed chemical study of the aerial parts and rhizomes of Hyalis argentea var. latisquama yielded a variety of sesqui- and diterpenes. In total, 26 compounds were isolated and identified, of which four are new, namely, two ent-kaurenes (1 and 2), a diterpene lactone (3), and a lindenanolide (4)....

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Detalles Bibliográficos
Publicado:	2014
Materias:	8alpha,9alpha exposyonoseriolide acetate amphotericin B ent 7alpha hydroxy 15 oxokauran 19 beta dextro glucopyranosyl ester ent 7alpha,15beta dihydroxykaur 16 ene 19 beta dextro glucopyranosyl ester hyalic acid beta dextro glucopyranosyl ester terpenoid derivative unclassified drug antifungal activity article Candida albicans controlled study Cryptococcus neoformans drug identification drug isolation fungus growth growth inhibition Hyalis latisquama medicinal plant nonhuman rhizome Antifungal Agents Asteraceae Diterpenes, Kaurane Molecular Structure Sesquiterpenes Sesquiterpenes, Guaiane
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v77_n7_p1579_Fernandez http://hdl.handle.net/20.500.12110/paper_01633864_v77_n7_p1579_Fernandez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01633864_v77_n7_p1579_Fernandez
record_format	dspace
spelling	paper:paper_01633864_v77_n7_p1579_Fernandez2023-06-08T15:14:20Z Antifungal terpenoids from Hyalis argentea var. latisquama 8alpha,9alpha exposyonoseriolide acetate amphotericin B ent 7alpha hydroxy 15 oxokauran 19 beta dextro glucopyranosyl ester ent 7alpha,15beta dihydroxykaur 16 ene 19 beta dextro glucopyranosyl ester hyalic acid beta dextro glucopyranosyl ester terpenoid derivative unclassified drug antifungal activity article Candida albicans controlled study Cryptococcus neoformans drug identification drug isolation fungus growth growth inhibition Hyalis latisquama medicinal plant nonhuman rhizome Antifungal Agents Asteraceae Candida albicans Cryptococcus neoformans Diterpenes, Kaurane Molecular Structure Sesquiterpenes Sesquiterpenes, Guaiane A detailed chemical study of the aerial parts and rhizomes of Hyalis argentea var. latisquama yielded a variety of sesqui- and diterpenes. In total, 26 compounds were isolated and identified, of which four are new, namely, two ent-kaurenes (1 and 2), a diterpene lactone (3), and a lindenanolide (4). The previously reported compounds included a series of lindenanolides, guaianolides, elemanolides, and additional diterpenes. The antifungal activity of the isolated compounds was tested against Cryptococcus neoformans and Candida albicans. Among the isolated compounds, the lindenanolides were the only structural class that showed strong antifungal activity, and onoseriolide acetate (5) was the most active. On the other hand, the isolated guaianolides were only moderately active, while the diterpenes did not show significant antifungal activity. © 2014 The American Chemical Society and American Society of Pharmacognosy. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v77_n7_p1579_Fernandez http://hdl.handle.net/20.500.12110/paper_01633864_v77_n7_p1579_Fernandez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	8alpha,9alpha exposyonoseriolide acetate amphotericin B ent 7alpha hydroxy 15 oxokauran 19 beta dextro glucopyranosyl ester ent 7alpha,15beta dihydroxykaur 16 ene 19 beta dextro glucopyranosyl ester hyalic acid beta dextro glucopyranosyl ester terpenoid derivative unclassified drug antifungal activity article Candida albicans controlled study Cryptococcus neoformans drug identification drug isolation fungus growth growth inhibition Hyalis latisquama medicinal plant nonhuman rhizome Antifungal Agents Asteraceae Candida albicans Cryptococcus neoformans Diterpenes, Kaurane Molecular Structure Sesquiterpenes Sesquiterpenes, Guaiane
spellingShingle	8alpha,9alpha exposyonoseriolide acetate amphotericin B ent 7alpha hydroxy 15 oxokauran 19 beta dextro glucopyranosyl ester ent 7alpha,15beta dihydroxykaur 16 ene 19 beta dextro glucopyranosyl ester hyalic acid beta dextro glucopyranosyl ester terpenoid derivative unclassified drug antifungal activity article Candida albicans controlled study Cryptococcus neoformans drug identification drug isolation fungus growth growth inhibition Hyalis latisquama medicinal plant nonhuman rhizome Antifungal Agents Asteraceae Candida albicans Cryptococcus neoformans Diterpenes, Kaurane Molecular Structure Sesquiterpenes Sesquiterpenes, Guaiane Antifungal terpenoids from Hyalis argentea var. latisquama
topic_facet	8alpha,9alpha exposyonoseriolide acetate amphotericin B ent 7alpha hydroxy 15 oxokauran 19 beta dextro glucopyranosyl ester ent 7alpha,15beta dihydroxykaur 16 ene 19 beta dextro glucopyranosyl ester hyalic acid beta dextro glucopyranosyl ester terpenoid derivative unclassified drug antifungal activity article Candida albicans controlled study Cryptococcus neoformans drug identification drug isolation fungus growth growth inhibition Hyalis latisquama medicinal plant nonhuman rhizome Antifungal Agents Asteraceae Candida albicans Cryptococcus neoformans Diterpenes, Kaurane Molecular Structure Sesquiterpenes Sesquiterpenes, Guaiane
description	A detailed chemical study of the aerial parts and rhizomes of Hyalis argentea var. latisquama yielded a variety of sesqui- and diterpenes. In total, 26 compounds were isolated and identified, of which four are new, namely, two ent-kaurenes (1 and 2), a diterpene lactone (3), and a lindenanolide (4). The previously reported compounds included a series of lindenanolides, guaianolides, elemanolides, and additional diterpenes. The antifungal activity of the isolated compounds was tested against Cryptococcus neoformans and Candida albicans. Among the isolated compounds, the lindenanolides were the only structural class that showed strong antifungal activity, and onoseriolide acetate (5) was the most active. On the other hand, the isolated guaianolides were only moderately active, while the diterpenes did not show significant antifungal activity. © 2014 The American Chemical Society and American Society of Pharmacognosy.
title	Antifungal terpenoids from Hyalis argentea var. latisquama
title_short	Antifungal terpenoids from Hyalis argentea var. latisquama
title_full	Antifungal terpenoids from Hyalis argentea var. latisquama
title_fullStr	Antifungal terpenoids from Hyalis argentea var. latisquama
title_full_unstemmed	Antifungal terpenoids from Hyalis argentea var. latisquama
title_sort	antifungal terpenoids from hyalis argentea var. latisquama
publishDate	2014
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v77_n7_p1579_Fernandez http://hdl.handle.net/20.500.12110/paper_01633864_v77_n7_p1579_Fernandez
_version_	1768546487414816768

Antifungal terpenoids from Hyalis argentea var. latisquama

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