Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica

Two new dolabellane diterpenoids (1 and 2) were isolated from a small sample of the deep water gorgonian octocoral Convexella magelhaenica collected as a nontarget by-catch by dredging (-93 m) in commercial Patagonian scallop fishing grounds in the South Atlantic. The structures of the new compounds...

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Publicado:	2010
Materias:	2,13 diacetoxydolabella 3,7,18 trien 9 one Convexella magelhaenica extract diterpenoid dolabella 3,7,18 trien 9 one dolabellane diterpenoid derivative plant extract unclassified drug (1R,3E,7E,11S,12R)-dolabella-3,7,18-trien-9-one (1S,2R,3E,7E,11S,12R,13S)-2,13-diacetoxydolabella-3,7,18-trien-9-one diterpene dolabellane animal cell article cancer cell culture concentration response Convexella magelhaenica coral drug cytotoxicity drug isolation human human cell IC 50 mouse nonhuman pancreas adenocarcinoma adenocarcinoma animal Anthozoa Atlantic Ocean chemical structure chemistry isolation and purification nuclear magnetic resonance Pancreatic Neoplasms Gorgonia Adenocarcinoma Animals Diterpenes Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v73_n10_p1714_RojoDeAlmeida http://hdl.handle.net/20.500.12110/paper_01633864_v73_n10_p1714_RojoDeAlmeida
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01633864_v73_n10_p1714_RojoDeAlmeida
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spelling	paper:paper_01633864_v73_n10_p1714_RojoDeAlmeida2023-06-08T15:14:18Z Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica 2,13 diacetoxydolabella 3,7,18 trien 9 one Convexella magelhaenica extract diterpenoid dolabella 3,7,18 trien 9 one dolabellane diterpenoid derivative plant extract unclassified drug (1R,3E,7E,11S,12R)-dolabella-3,7,18-trien-9-one (1S,2R,3E,7E,11S,12R,13S)-2,13-diacetoxydolabella-3,7,18-trien-9-one diterpene dolabellane animal cell article cancer cell culture concentration response Convexella magelhaenica coral drug cytotoxicity drug isolation human human cell IC 50 mouse nonhuman pancreas adenocarcinoma adenocarcinoma animal Anthozoa Atlantic Ocean chemical structure chemistry isolation and purification nuclear magnetic resonance Pancreatic Neoplasms Gorgonia Adenocarcinoma Animals Anthozoa Atlantic Ocean Diterpenes Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pancreatic Neoplasms Two new dolabellane diterpenoids (1 and 2) were isolated from a small sample of the deep water gorgonian octocoral Convexella magelhaenica collected as a nontarget by-catch by dredging (-93 m) in commercial Patagonian scallop fishing grounds in the South Atlantic. The structures of the new compounds, which are major metabolites in the extract, were established by spectroscopic techniques and chemical transformations. Both compounds were cytotoxic against a human pancreatic adenocarcinoma cell line at micromolar concentrations. © 2010 The American Chemical Society and American Society of Pharmacognosy. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v73_n10_p1714_RojoDeAlmeida http://hdl.handle.net/20.500.12110/paper_01633864_v73_n10_p1714_RojoDeAlmeida
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	2,13 diacetoxydolabella 3,7,18 trien 9 one Convexella magelhaenica extract diterpenoid dolabella 3,7,18 trien 9 one dolabellane diterpenoid derivative plant extract unclassified drug (1R,3E,7E,11S,12R)-dolabella-3,7,18-trien-9-one (1S,2R,3E,7E,11S,12R,13S)-2,13-diacetoxydolabella-3,7,18-trien-9-one diterpene dolabellane animal cell article cancer cell culture concentration response Convexella magelhaenica coral drug cytotoxicity drug isolation human human cell IC 50 mouse nonhuman pancreas adenocarcinoma adenocarcinoma animal Anthozoa Atlantic Ocean chemical structure chemistry isolation and purification nuclear magnetic resonance Pancreatic Neoplasms Gorgonia Adenocarcinoma Animals Anthozoa Atlantic Ocean Diterpenes Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pancreatic Neoplasms
spellingShingle	2,13 diacetoxydolabella 3,7,18 trien 9 one Convexella magelhaenica extract diterpenoid dolabella 3,7,18 trien 9 one dolabellane diterpenoid derivative plant extract unclassified drug (1R,3E,7E,11S,12R)-dolabella-3,7,18-trien-9-one (1S,2R,3E,7E,11S,12R,13S)-2,13-diacetoxydolabella-3,7,18-trien-9-one diterpene dolabellane animal cell article cancer cell culture concentration response Convexella magelhaenica coral drug cytotoxicity drug isolation human human cell IC 50 mouse nonhuman pancreas adenocarcinoma adenocarcinoma animal Anthozoa Atlantic Ocean chemical structure chemistry isolation and purification nuclear magnetic resonance Pancreatic Neoplasms Gorgonia Adenocarcinoma Animals Anthozoa Atlantic Ocean Diterpenes Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pancreatic Neoplasms Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica
topic_facet	2,13 diacetoxydolabella 3,7,18 trien 9 one Convexella magelhaenica extract diterpenoid dolabella 3,7,18 trien 9 one dolabellane diterpenoid derivative plant extract unclassified drug (1R,3E,7E,11S,12R)-dolabella-3,7,18-trien-9-one (1S,2R,3E,7E,11S,12R,13S)-2,13-diacetoxydolabella-3,7,18-trien-9-one diterpene dolabellane animal cell article cancer cell culture concentration response Convexella magelhaenica coral drug cytotoxicity drug isolation human human cell IC 50 mouse nonhuman pancreas adenocarcinoma adenocarcinoma animal Anthozoa Atlantic Ocean chemical structure chemistry isolation and purification nuclear magnetic resonance Pancreatic Neoplasms Gorgonia Adenocarcinoma Animals Anthozoa Atlantic Ocean Diterpenes Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pancreatic Neoplasms
description	Two new dolabellane diterpenoids (1 and 2) were isolated from a small sample of the deep water gorgonian octocoral Convexella magelhaenica collected as a nontarget by-catch by dredging (-93 m) in commercial Patagonian scallop fishing grounds in the South Atlantic. The structures of the new compounds, which are major metabolites in the extract, were established by spectroscopic techniques and chemical transformations. Both compounds were cytotoxic against a human pancreatic adenocarcinoma cell line at micromolar concentrations. © 2010 The American Chemical Society and American Society of Pharmacognosy.
title	Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica
title_short	Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica
title_full	Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica
title_fullStr	Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica
title_full_unstemmed	Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica
title_sort	dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica
publishDate	2010
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v73_n10_p1714_RojoDeAlmeida http://hdl.handle.net/20.500.12110/paper_01633864_v73_n10_p1714_RojoDeAlmeida
_version_	1768541982579228672

Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica

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