Induction of quinone reductase by withanolides

Thirty-seven naturally occurring withanolides (1-37), previously isolated in our laboratories, were evaluated for their potential to induce quinone reductase with cultured murine hepatoma cells (Hepa 1c1c7). Spiranoid (29, 32) and 18-functionalized withanolides (2-5, 7-9, 24) were found to be potent...

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Autores principales:	Veleiro, Adriana Silvia, Cirigliano, Adriana Mónica, Tettamanzi, María Cristina, Burton, Gerardo
Publicado:	2002
Materias:	18 hydroxywithanolide d enzyme inducing agent jaborosalactone 1 joborosalactone p reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone) unclassified drug withanolide derivative withaphysalin g withaphysalin h withaphysalin i withaphysalin j animal cell animal experiment animal tissue article breast colon concentration response controlled study drug potency drug structure enzyme induction hepatoma cell liver lung mouse nonhuman phytochemistry stomach Animals Brassicaceae Breast Carcinoma, Hepatocellular Colon Enzyme Induction Inhibitory Concentration 50 Liver Lung Mice Mice, Inbred BALB C Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal Quinone Reductases Solanaceae Stereoisomerism Steroids Stilbenes Stomach Tumor Cells, Cultured Animalia Murinae
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v65_n5_p677_Misico http://hdl.handle.net/20.500.12110/paper_01633864_v65_n5_p677_Misico
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01633864_v65_n5_p677_Misico
record_format	dspace
spelling	paper:paper_01633864_v65_n5_p677_Misico2023-06-08T15:14:15Z Induction of quinone reductase by withanolides Veleiro, Adriana Silvia Cirigliano, Adriana Mónica Tettamanzi, María Cristina Burton, Gerardo 18 hydroxywithanolide d enzyme inducing agent jaborosalactone 1 joborosalactone p reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone) unclassified drug withanolide derivative withaphysalin g withaphysalin h withaphysalin i withaphysalin j animal cell animal experiment animal tissue article breast colon concentration response controlled study drug potency drug structure enzyme induction hepatoma cell liver lung mouse nonhuman phytochemistry stomach Animals Brassicaceae Breast Carcinoma, Hepatocellular Colon Enzyme Induction Inhibitory Concentration 50 Liver Lung Mice Mice, Inbred BALB C Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal Quinone Reductases Solanaceae Stereoisomerism Steroids Stilbenes Stomach Tumor Cells, Cultured Animalia Murinae Thirty-seven naturally occurring withanolides (1-37), previously isolated in our laboratories, were evaluated for their potential to induce quinone reductase with cultured murine hepatoma cells (Hepa 1c1c7). Spiranoid (29, 32) and 18-functionalized withanolides (2-5, 7-9, 24) were found to be potent inducers of the enzyme, while 5α-substituted derivatives exhibited weak activity. Preliminary studies were performed with compound 29 to evaluate enzyme-inducing capacity in multiple organ sites of BALB/c mice. Significant induction was observed in liver and colon, but not in lung, stomach, or mammary gland. Fil:Veleiro, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cirigliano, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Tettamanzi, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2002 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v65_n5_p677_Misico http://hdl.handle.net/20.500.12110/paper_01633864_v65_n5_p677_Misico
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	18 hydroxywithanolide d enzyme inducing agent jaborosalactone 1 joborosalactone p reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone) unclassified drug withanolide derivative withaphysalin g withaphysalin h withaphysalin i withaphysalin j animal cell animal experiment animal tissue article breast colon concentration response controlled study drug potency drug structure enzyme induction hepatoma cell liver lung mouse nonhuman phytochemistry stomach Animals Brassicaceae Breast Carcinoma, Hepatocellular Colon Enzyme Induction Inhibitory Concentration 50 Liver Lung Mice Mice, Inbred BALB C Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal Quinone Reductases Solanaceae Stereoisomerism Steroids Stilbenes Stomach Tumor Cells, Cultured Animalia Murinae
spellingShingle	18 hydroxywithanolide d enzyme inducing agent jaborosalactone 1 joborosalactone p reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone) unclassified drug withanolide derivative withaphysalin g withaphysalin h withaphysalin i withaphysalin j animal cell animal experiment animal tissue article breast colon concentration response controlled study drug potency drug structure enzyme induction hepatoma cell liver lung mouse nonhuman phytochemistry stomach Animals Brassicaceae Breast Carcinoma, Hepatocellular Colon Enzyme Induction Inhibitory Concentration 50 Liver Lung Mice Mice, Inbred BALB C Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal Quinone Reductases Solanaceae Stereoisomerism Steroids Stilbenes Stomach Tumor Cells, Cultured Animalia Murinae Veleiro, Adriana Silvia Cirigliano, Adriana Mónica Tettamanzi, María Cristina Burton, Gerardo Induction of quinone reductase by withanolides
topic_facet	18 hydroxywithanolide d enzyme inducing agent jaborosalactone 1 joborosalactone p reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone) unclassified drug withanolide derivative withaphysalin g withaphysalin h withaphysalin i withaphysalin j animal cell animal experiment animal tissue article breast colon concentration response controlled study drug potency drug structure enzyme induction hepatoma cell liver lung mouse nonhuman phytochemistry stomach Animals Brassicaceae Breast Carcinoma, Hepatocellular Colon Enzyme Induction Inhibitory Concentration 50 Liver Lung Mice Mice, Inbred BALB C Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal Quinone Reductases Solanaceae Stereoisomerism Steroids Stilbenes Stomach Tumor Cells, Cultured Animalia Murinae
description	Thirty-seven naturally occurring withanolides (1-37), previously isolated in our laboratories, were evaluated for their potential to induce quinone reductase with cultured murine hepatoma cells (Hepa 1c1c7). Spiranoid (29, 32) and 18-functionalized withanolides (2-5, 7-9, 24) were found to be potent inducers of the enzyme, while 5α-substituted derivatives exhibited weak activity. Preliminary studies were performed with compound 29 to evaluate enzyme-inducing capacity in multiple organ sites of BALB/c mice. Significant induction was observed in liver and colon, but not in lung, stomach, or mammary gland.
author	Veleiro, Adriana Silvia Cirigliano, Adriana Mónica Tettamanzi, María Cristina Burton, Gerardo
author_facet	Veleiro, Adriana Silvia Cirigliano, Adriana Mónica Tettamanzi, María Cristina Burton, Gerardo
author_sort	Veleiro, Adriana Silvia
title	Induction of quinone reductase by withanolides
title_short	Induction of quinone reductase by withanolides
title_full	Induction of quinone reductase by withanolides
title_fullStr	Induction of quinone reductase by withanolides
title_full_unstemmed	Induction of quinone reductase by withanolides
title_sort	induction of quinone reductase by withanolides
publishDate	2002
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v65_n5_p677_Misico http://hdl.handle.net/20.500.12110/paper_01633864_v65_n5_p677_Misico
work_keys_str_mv	AT veleiroadrianasilvia inductionofquinonereductasebywithanolides AT ciriglianoadrianamonica inductionofquinonereductasebywithanolides AT tettamanzimariacristina inductionofquinonereductasebywithanolides AT burtongerardo inductionofquinonereductasebywithanolides
_version_	1768546623943606272

Induction of quinone reductase by withanolides

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